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==Natural history, complications and prognosis== | ==Natural history, complications and prognosis== | ||
'''Natural History''' | '''Natural History''' | ||
*The symptoms of TBMD are usually developed in first decade of life and start with symptoms such as recurrent hematuria. It occurs rarely after age 50 years. | |||
*The symptoms of TBMD typically are not present initially, are found incidentally as microscopic hematuria, mild proteinuria in routine urine analysis and macroscopic hematuria rarely.<ref name="pmid19670702">{{cite journal |vauthors=Zurawski J, Salwa-Zurawska W, Woźniak A, Bortkiewicz E, Maciejewski J, Idasiak-Piechocka I, Urbański B |title=Clinical and morphological aspects of thin glomerular basement membrane disease |journal=Pol J Pathol |volume=60 |issue=1 |pages=35–42 |date=2009 |pmid=19670702 |doi= |url=}}</ref> | *The symptoms of [[Thin basement membrane disease|TBMD]] are usually developed in first decade of life and start with symptoms such as [[Benign Recurrent Hamaturia|recurrent hematuria]]. It occurs rarely after age 50 years. | ||
*If left untreated, adult TBMD patients with proteinuria may develop | *The symptoms of [[Thin basement membrane disease|TBMD]] typically are not present initially, are found incidentally as [[microscopic hematuria]], [[Proteinuria|mild proteinuria]] in [[Urinalysis|routine urine analysis]] and [[Hematuria|macroscopic hematuria]] rarely.<ref name="pmid19670702">{{cite journal |vauthors=Zurawski J, Salwa-Zurawska W, Woźniak A, Bortkiewicz E, Maciejewski J, Idasiak-Piechocka I, Urbański B |title=Clinical and morphological aspects of thin glomerular basement membrane disease |journal=Pol J Pathol |volume=60 |issue=1 |pages=35–42 |date=2009 |pmid=19670702 |doi= |url=}}</ref> | ||
*If left untreated, adult [[Thin basement membrane disease|TBMD]] patients with [[proteinuria]] may develop [[hypertension]], [[renal impairment]] leading to [[renal insufficiency]]. <ref name="pmid15880328">{{cite journal |vauthors=Tonna S, Wang YY, MacGregor D, Sinclair R, Martinello P, Power D, Savige J |title=The risks of thin basement membrane nephropathy |journal=Semin Nephrol |volume=25 |issue=3 |pages=171–5 |date=May 2005 |pmid=15880328 |doi=10.1016/j.semnephrol.2005.01.009 |url=}}</ref> | |||
'''Complication''' | '''Complication''' | ||
Common complications of TBMD include<ref name="pmid15880328">{{cite journal |vauthors=Tonna S, Wang YY, MacGregor D, Sinclair R, Martinello P, Power D, Savige J |title=The risks of thin basement membrane nephropathy |journal=Semin Nephrol |volume=25 |issue=3 |pages=171–5 |date=May 2005 |pmid=15880328 |doi=10.1016/j.semnephrol.2005.01.009 |url=}}</ref>: | Common complications of [[Thin basement membrane disease|TBMD]] include<ref name="pmid15880328">{{cite journal |vauthors=Tonna S, Wang YY, MacGregor D, Sinclair R, Martinello P, Power D, Savige J |title=The risks of thin basement membrane nephropathy |journal=Semin Nephrol |volume=25 |issue=3 |pages=171–5 |date=May 2005 |pmid=15880328 |doi=10.1016/j.semnephrol.2005.01.009 |url=}}</ref>: | ||
*Hypertension. | |||
*Proteinuria. | *[[Hypertension]]. | ||
*Renal impairment. | *[[Proteinuria]]. | ||
*Renal failure. | *[[Renal impairment|Renal impairment.]] | ||
*[[Renal failure|Renal failure.]] | |||
*Anxiety. | *Anxiety. | ||
'''Prognosis''' | '''Prognosis''' | ||
*Prognosis is good in patient with isolated hematuria. | |||
*The presence of proteinuria or other glomerulopathy is associated with a particularly poor prognosis among patients with TBMD.<ref name="pmid31288791">{{cite journal |vauthors=Hashimoto H, Ohashi N, Tsuji N, Naito Y, Isobe S, Fujikura T, Tsuji T, Kato A, Nozu K, Iijima K, Yasuda H |title=A case report of thin basement membrane nephropathy accompanied by sporadic glomerulocystic kidney disease |journal=BMC Nephrol |volume=20 |issue=1 |pages=248 |date=July 2019 |pmid=31288791 |pmc=6617628 |doi=10.1186/s12882-019-1451-6 |url=}}</ref><ref name="pmid15880329">{{cite journal |vauthors=Norby SM, Cosio FG |title=Thin basement membrane nephropathy associated with other glomerular diseases |journal=Semin Nephrol |volume=25 |issue=3 |pages=176–9 |date=May 2005 |pmid=15880329 |doi=10.1016/j.semnephrol.2005.01.010 |url=}}</ref> | *[[Prognosis]] is good in patient with isolated [[hematuria]]. | ||
*The presence of [[proteinuria]] or other [[glomerulopathy]] is associated with a particularly [[Prognosis|poor prognosis]] among patients with [[Thin basement membrane disease|TBMD]].<ref name="pmid31288791">{{cite journal |vauthors=Hashimoto H, Ohashi N, Tsuji N, Naito Y, Isobe S, Fujikura T, Tsuji T, Kato A, Nozu K, Iijima K, Yasuda H |title=A case report of thin basement membrane nephropathy accompanied by sporadic glomerulocystic kidney disease |journal=BMC Nephrol |volume=20 |issue=1 |pages=248 |date=July 2019 |pmid=31288791 |pmc=6617628 |doi=10.1186/s12882-019-1451-6 |url=}}</ref><ref name="pmid15880329">{{cite journal |vauthors=Norby SM, Cosio FG |title=Thin basement membrane nephropathy associated with other glomerular diseases |journal=Semin Nephrol |volume=25 |issue=3 |pages=176–9 |date=May 2005 |pmid=15880329 |doi=10.1016/j.semnephrol.2005.01.010 |url=}}</ref> | |||
==References== | ==References== | ||
Revision as of 18:27, 20 October 2020
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Overview
Natural history, complications and prognosis
Natural History
- The symptoms of TBMD are usually developed in first decade of life and start with symptoms such as recurrent hematuria. It occurs rarely after age 50 years.
- The symptoms of TBMD typically are not present initially, are found incidentally as microscopic hematuria, mild proteinuria in routine urine analysis and macroscopic hematuria rarely.[1]
- If left untreated, adult TBMD patients with proteinuria may develop hypertension, renal impairment leading to renal insufficiency. [2]
Complication
Common complications of TBMD include[2]:
- Hypertension.
- Proteinuria.
- Renal impairment.
- Renal failure.
- Anxiety.
Prognosis
- Prognosis is good in patient with isolated hematuria.
- The presence of proteinuria or other glomerulopathy is associated with a particularly poor prognosis among patients with TBMD.[3][4]
References
- ↑ Zurawski J, Salwa-Zurawska W, Woźniak A, Bortkiewicz E, Maciejewski J, Idasiak-Piechocka I, Urbański B (2009). "Clinical and morphological aspects of thin glomerular basement membrane disease". Pol J Pathol. 60 (1): 35–42. PMID 19670702.
- ↑ 2.0 2.1 Tonna S, Wang YY, MacGregor D, Sinclair R, Martinello P, Power D, Savige J (May 2005). "The risks of thin basement membrane nephropathy". Semin Nephrol. 25 (3): 171–5. doi:10.1016/j.semnephrol.2005.01.009. PMID 15880328.
- ↑ Hashimoto H, Ohashi N, Tsuji N, Naito Y, Isobe S, Fujikura T, Tsuji T, Kato A, Nozu K, Iijima K, Yasuda H (July 2019). "A case report of thin basement membrane nephropathy accompanied by sporadic glomerulocystic kidney disease". BMC Nephrol. 20 (1): 248. doi:10.1186/s12882-019-1451-6. PMC 6617628 Check
|pmc=value (help). PMID 31288791. - ↑ Norby SM, Cosio FG (May 2005). "Thin basement membrane nephropathy associated with other glomerular diseases". Semin Nephrol. 25 (3): 176–9. doi:10.1016/j.semnephrol.2005.01.010. PMID 15880329.