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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Scurvy is a chronic deficiency disease of vitamin C, which is necessary for normal collagen formation in humans. L-ascorbic acid, the scientific name for vitamin c, is derived from the Latin name, scorbutus. Early symptoms of this disease are fatigue, weakness, and sore arms and legs. Without treatment, changes in hair, skin, and gums occur. As scurvy worsens there can be personality changes, poor wound healing and ultimately leading to death due to bleeding or infection. Previously, this disease was common among pirates, sailors, and all others who were separated from the resources of vitamin c e.g. fruits and vegetables for extended periods. It takes a month with low or no vitamin c to cause symptoms. In infants, scurvy is sometimes referred to as Barlow's disease, named after Sir Thomas Barlow (1845–1945), a British physician who described it. Other eponyms include Moeller's disease and Cheadle's disease. In the modern world, scurvy rarely presents in adults, infants and elderly are affected more. Vitamin C, a water soluble vitamin, can easily be destroyed by pasteurization. So bottle fed babies, not supplemented with adequate vitamin, can easily develop scurvy. For this reason, vitamin C is added to all approved baby formulas. If mothers take adequate amount of vitamin C, then breast milk is sufficient for the babies need of this vitamin.

Pathophysiology

Physiology

Vitamins are very important for the formation and normal functioning of enzymes that are responsible for multiple processes in the human body. Ascorbic acid is necessary for accelerating amidation reactions and hydroxylation in normal collagen synthesis. The hydroxylation of lysine and proline residues occurs in endoplasmic reticulum and leads to hydroxylysine and hydroxyproline, respectively. Enzymes responsible for these reactions are lysyl hydroxylase and prolyl hydroxylase. For healthy skin, bone, muscles, cartilage, blood vessels, and other connective tissues, the primary structure collagen protein is required with a proper synthesis and normal functioning.

Pathogenesis

Defective collagen leads to abnormalities in all connective tissue areas. In blood vessels, defective connective tissue leads to fragile capillaries and causes bruising, abnormal bleeding, and internal hemorrhages. Similarly, teeth loosen, bones are easily breakable, recurrence of fractures, and poor wound healing. Scurvy is fatal if left untreated.