Duchenne muscular dystrophy natural history, complications and prognosis: Difference between revisions
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===Complications=== | ===Complications=== | ||
*Common complications of Duchenne muscular dystrophy include: | *Common complications of Duchenne muscular dystrophy include:<ref name="NigroComi1990">{{cite journal|last1=Nigro|first1=G.|last2=Comi|first2=L.I.|last3=Politano|first3=L.|last4=Bain|first4=R.J.I.|title=The incidence and evolution of cardiomyopathy in Duchenne muscular dystrophy|journal=International Journal of Cardiology|volume=26|issue=3|year=1990|pages=271–277|issn=01675273|doi=10.1016/0167-5273(90)90082-G}}</ref><ref name="pmid29395990">{{cite journal |vauthors=Birnkrant DJ, Bushby K, Bann CM, Alman BA, Apkon SD, Blackwell A, Case LE, Cripe L, Hadjiyannakis S, Olson AK, Sheehan DW, Bolen J, Weber DR, Ward LM |title=Diagnosis and management of Duchenne muscular dystrophy, part 2: respiratory, cardiac, bone health, and orthopaedic management |journal=Lancet Neurol |volume=17 |issue=4 |pages=347–361 |date=April 2018 |pmid=29395990 |pmc=5889091 |doi=10.1016/S1474-4422(18)30025-5 |url=}}</ref><ref name="FitzpatrickBarry2008">{{cite journal|last1=Fitzpatrick|first1=Carol|last2=Barry|first2=Ciaran|last3=Garvey|first3=Criona|title=PSYCHIATRIC DISORDER AMONG BOYS WITH DUCHENNE MUSCULAR DYSTROPHY|journal=Developmental Medicine & Child Neurology|volume=28|issue=5|year=2008|pages=589–595|issn=00121622|doi=10.1111/j.1469-8749.1986.tb03900.x}}</ref><ref name="pmid2760082">{{cite journal |vauthors=Smith AD, Koreska J, Moseley CF |title=Progression of scoliosis in Duchenne muscular dystrophy |journal=J Bone Joint Surg Am |volume=71 |issue=7 |pages=1066–74 |date=August 1989 |pmid=2760082 |doi= |url=}}</ref> | ||
** [[Cardiomyopathy]] with [[heart failure]] | ** [[Cardiomyopathy]] with [[heart failure]] | ||
** [[Respiratory failure]] | ** [[Respiratory failure]] | ||
Revision as of 15:00, 29 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.
Overview
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of Duchenne muscular dystrophy usually develop in the first decade of life, and start with symptoms such as muscle weakness and gait abnormalities.
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
Complications
- Cardiomyopathy with heart failure
- Respiratory failure
- Cataracts
- Decreased movement
- Depression
- Contractures
- Mental impairment
- Scoliosis
- Failure to thrive
Prognosis
- Prognosis is generally poor, and the mortality rate of patients with Duchenne muscular dystrophy is approximately 100%.[5]
- The presence of low vital capacity or a sharp decline of vital capacity is associated with a particularly poor prognosis among patients with Duchenne muscular dystrophy.
References
- ↑ Nigro, G.; Comi, L.I.; Politano, L.; Bain, R.J.I. (1990). "The incidence and evolution of cardiomyopathy in Duchenne muscular dystrophy". International Journal of Cardiology. 26 (3): 271–277. doi:10.1016/0167-5273(90)90082-G. ISSN 0167-5273.
- ↑ Birnkrant DJ, Bushby K, Bann CM, Alman BA, Apkon SD, Blackwell A, Case LE, Cripe L, Hadjiyannakis S, Olson AK, Sheehan DW, Bolen J, Weber DR, Ward LM (April 2018). "Diagnosis and management of Duchenne muscular dystrophy, part 2: respiratory, cardiac, bone health, and orthopaedic management". Lancet Neurol. 17 (4): 347–361. doi:10.1016/S1474-4422(18)30025-5. PMC 5889091. PMID 29395990.
- ↑ Fitzpatrick, Carol; Barry, Ciaran; Garvey, Criona (2008). "PSYCHIATRIC DISORDER AMONG BOYS WITH DUCHENNE MUSCULAR DYSTROPHY". Developmental Medicine & Child Neurology. 28 (5): 589–595. doi:10.1111/j.1469-8749.1986.tb03900.x. ISSN 0012-1622.
- ↑ Smith AD, Koreska J, Moseley CF (August 1989). "Progression of scoliosis in Duchenne muscular dystrophy". J Bone Joint Surg Am. 71 (7): 1066–74. PMID 2760082.
- ↑ Visser, Jeldican; van den Berg-Vos, Renske M.; Franssen, Hessel; van den Berg, Leonard H.; Wokke, John H.; Vianney de Jong, J. M.; Holman, Rebecca; de Haan, Rob J.; de Visser, Marianne (2007). "Disease Course and Prognostic Factors of Progressive Muscular Atrophy". Archives of Neurology. 64 (4): 522. doi:10.1001/archneur.64.4.522. ISSN 0003-9942.