Ovarian germ cell tumor diagnostic study of choice: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
(Created page with "__NOTOC__ {{Ovarian germ cell tumor}} {{CMG}}; {{AE}} == Overview == == Diagnostic Study of Choice == === Study of choice === [Name of the investigation] is the gold standar...")
 
No edit summary
Line 3: Line 3:
{{CMG}}; {{AE}}
{{CMG}}; {{AE}}
== Overview ==
== Overview ==
 
Histology of the excised tumor after surgery is the gold standard test for the diagnosis of ovarian germ cell tumors. Surgery must be performed when the patient presents with an adnexal mass in the abdominal/pelvic exam and elevated serum concentration of associated tumor markers. Mature teratoma may be diagnosed using ultrasonographic imaging. However, the tumor should be removed surgically.
== Diagnostic Study of Choice ==
== Diagnostic Study of Choice ==
Histology of the excised tumor after surgery is the gold standard test for the diagnosis of ovarian germ cell tumors.<ref name="PectasidesPectasides2008">{{cite journal|last1=Pectasides|first1=D.|last2=Pectasides|first2=E.|last3=Kassanos|first3=D.|title=Germ cell tumors of the ovary|journal=Cancer Treatment Reviews|volume=34|issue=5|year=2008|pages=427–441|issn=03057372|doi=10.1016/j.ctrv.2008.02.002}}</ref><ref name="LowIlancheran2012">{{cite journal|last1=Low|first1=Jeffrey J.H.|last2=Ilancheran|first2=Arunachalam|last3=Ng|first3=Joseph S.|title=Malignant ovarian germ-cell tumours|journal=Best Practice & Research Clinical Obstetrics & Gynaecology|volume=26|issue=3|year=2012|pages=347–355|issn=15216934|doi=10.1016/j.bpobgyn.2012.01.002}}</ref>
Surgery must be performed when:
* The patient presents with an adnexal mass in the abdominal/pelvic exam, and elevated serum concentration of hCG, LDH, AFP, and other associated tumor markers.
* Mature teratoma may be diagnosed using ultrasonographic imaging. However, the tumor should be removed surgically.


=== Study of choice ===
{{familytree/start |summary=PE diagnosis Algorithm.}}
[Name of the investigation] is the gold standard test for the diagnosis of [disease name].
{{familytree | | | | | | | | | | A02 | | | | | |A02=Malignant germ cell tumor}}
 
{{familytree | | | |,|-|-|-|-|-|-|^|-|-|-|-|-|-|-|.| | | | | | }}
OR
{{familytree | | | C01 | | | | | | | | | | | | | C02 | | |C01=Prior surgery|C02=Initial surgery}}
 
{{familytree | |,|-|^|-|.| | | | | | | | | | |,|-|^|-|.| | }}
The following result of [gold standard test] is confirmatory of [disease name]:
{{familytree | D01 | | D02 | | | | | | | | | D03 | | D04 |D01=Complete staging|D02=Incomplete staging|D03=Fertility sparing prefered|D04=Fertility sparing not prefered}}
* [Result 1]
{{familytree | |!| | | |!| | | | | | | | | | |!| | | |!| | }}
* [Result 2]
{{familytree | E01 | | E02 | | | | | | | | | E03 | | E04 |E01=Treatment based<br>on<br>the staging|E02=Imaging:<br>Chest/<br>abdomen/<br>pelvis CT with contrast|E03=Fertility sparing surgery<br>and<br>complete staging|E04=Surgery to stage}}
 
{{familytree | | | | | |!| | | | | | | | | | |!| | | |!| | | | }}
OR
{{familytree | | | | | |!| | | | | | | | | | |`| F02 |'| | | |F02=Treatment based on the staging and pathology of tumor}}
 
{{familytree | | | |,|-|^|-|-|-|-|-|-|-|.| | | | | | | }}
[Name of the investigation] must be performed when:
{{familytree | | | G01 | | | | | | | | G02 | | | | | | | | | | | | | | |G01=Yolk sac tumor<br>grade2-3 immature teratoma,<br>non-gestational choriocarcinoma<br>or mixed histology|G02=Dysgerminoma<br>or<br>grade 1 immature teratoma|L03=Dysgerminoma or grade 1 immature teratoma}}
* The patient presents with [symptom/sign 1], [symptom/sign 2], and [symptom/sign 3].
{{familytree | | | |!| | | | | | | | | |!| | | | | | | | | | | | }}
* A [name of test] is positive for [sign 1], [sign 2], and [sign 3] in the patient.
{{familytree | | | |!| | | | | |,|-|-|-|+|-|-|-|.|}}
 
{{familytree | | | |!| | | | | I02 | | I03 | | I04 | |I02=Imaging and tumor markers<br>are<br>positive|I03=Negative imaging<br>and<br>positive tumor markers|I04=Negative imaging<br>and<br>negative or positive tumor markers}}
OR
{{familytree | | | |!| | | | | |!| | | |!| | | |!| | | |}}
 
{{familytree | |,|-|^|-|.| | | K03 | | K04 | | K05 | | |K03=Decide according to fertility sparing preference<br>and/or pathologic finding<br>for surgery and<br>further adjuant therapy|K04=Observe|K05=Observe|}}
[Name of the investigation] is the gold standard test for the diagnosis of [disease name].
{{familytree | J01 | | J02 | | | | | | | | | | | | | | | | | | |J01=Imaging and tumor markers<br>are<br>positive|J02=Negative imaging<br>and<br>negative and positive tumor markers}}
 
{{familytree | |!| | | | | | | | | | | | | | | | | | | | | |}}
OR
{{familytree | K01 | | | | | | | | | | | | | | | | | | | |K01=Decide<br>according to<br>fertility sparing preference<br>for surgery and further chemotherapy|}}
 
{{familytree | | | | | | | | | | | | | | | | | | | | | | | |}}
The diagnostic study of choice for [disease name] is [name of the investigation].
{{familytree | | | | | | | | | | | | | | | | | | | | | | | |}}
 
{{familytree/end}}
OR
 
There is no single diagnostic study of choice for the diagnosis of [disease name].
 
OR
 
There is no single diagnostic study of choice for the diagnosis of [disease name], but [disease name] can be diagnosed based on [name of the investigation 1] and [name of the investigation 2].
 
OR
 
[Disease name] is primarily diagnosed based on the clinical presentation.
 
OR
 
Investigations:
* Among the patients who present with clinical signs of [disease name], the [investigation name] is the most specific test for the diagnosis.
* Among the patients who present with clinical signs of [disease name], the [investigation name] is the most sensitive test for diagnosis.
* Among the patients who present with clinical signs of [disease name], the [investigation name] is the most efficient test for diagnosis.
 
==== The comparison of various diagnostic studies for [disease name] ====
{|
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
! style="background: #4479BA; color: #FFFFFF; text-align: center;" | Test
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Sensitivity
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Specificity
|-
! style="background: #696969; color: #FFFFFF; text-align: center;" |Test 1
| style="background: #DCDCDC; padding: 5px; text-align: center;" |...%
| style="background: #DCDCDC; padding: 5px; text-align: center;" |...%
|-
! style="background: #696969; color: #FFFFFF; text-align: center;" |Test 2
| style="background: #DCDCDC; padding: 5px; text-align: center;" |...%
| style="background: #DCDCDC; padding: 5px; text-align: center;" |...%
|}
<small> [Name of test with higher sensitivity and specificity] is the preferred investigation based on the sensitivity and specificity</small>
 
===== Diagnostic results =====
The following finding(s) on performing [investigation name] is(are) confirmatory for [disease name]:
* [Finding 1]
* [Finding 2]
 
===== Sequence of Diagnostic Studies =====
The [name of investigation] must be performed when:
* The patient presented with symptoms/signs 1, 2, and 3 as the first step of diagnosis.
* A positive [test] is detected in the patient, to confirm the diagnosis.
 
OR
 
The various investigations must be performed in the following order:
* [Initial investigation]
* [2nd investigation]


=== Name of Diagnostic Criteria ===
=== Name of Diagnostic Criteria ===

Revision as of 19:24, 13 March 2019

Ovarian germ cell tumor Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Epidemiology and Demographics

Risk Factors

Screening

Differentiating Ovarian germ cell tumor from other Diseases

Natural History, Complications and Prognosis

Diagnosis

Staging

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Surgery

Chemotherapy

Radiotherapy

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Ovarian germ cell tumor diagnostic study of choice On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Ovarian germ cell tumor diagnostic study of choice

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Ovarian germ cell tumor diagnostic study of choice

CDC on Ovarian germ cell tumor diagnostic study of choice

Ovarian germ cell tumor diagnostic study of choice in the news

Blogs on Ovarian germ cell tumor diagnostic study of choice

Directions to Hospitals Treating Ovarian germ cell tumor

Risk calculators and risk factors for Ovarian germ cell tumor diagnostic study of choice

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Histology of the excised tumor after surgery is the gold standard test for the diagnosis of ovarian germ cell tumors. Surgery must be performed when the patient presents with an adnexal mass in the abdominal/pelvic exam and elevated serum concentration of associated tumor markers. Mature teratoma may be diagnosed using ultrasonographic imaging. However, the tumor should be removed surgically.

Diagnostic Study of Choice

Histology of the excised tumor after surgery is the gold standard test for the diagnosis of ovarian germ cell tumors.[1][2] Surgery must be performed when:

  • The patient presents with an adnexal mass in the abdominal/pelvic exam, and elevated serum concentration of hCG, LDH, AFP, and other associated tumor markers.
  • Mature teratoma may be diagnosed using ultrasonographic imaging. However, the tumor should be removed surgically.
 
 
 
 
 
 
 
 
 
Malignant germ cell tumor
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Prior surgery
 
 
 
 
 
 
 
 
 
 
 
 
Initial surgery
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Complete staging
 
Incomplete staging
 
 
 
 
 
 
 
 
Fertility sparing prefered
 
Fertility sparing not prefered
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Treatment based
on
the staging
 
Imaging:
Chest/
abdomen/
pelvis CT with contrast
 
 
 
 
 
 
 
 
Fertility sparing surgery
and
complete staging
 
Surgery to stage
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Treatment based on the staging and pathology of tumor
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Yolk sac tumor
grade2-3 immature teratoma,
non-gestational choriocarcinoma
or mixed histology
 
 
 
 
 
 
 
Dysgerminoma
or
grade 1 immature teratoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Imaging and tumor markers
are
positive
 
Negative imaging
and
positive tumor markers
 
Negative imaging
and
negative or positive tumor markers
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Decide according to fertility sparing preference
and/or pathologic finding
for surgery and
further adjuant therapy
 
Observe
 
Observe
 
 
 
 
 
 
 
 
Imaging and tumor markers
are
positive
 
Negative imaging
and
negative and positive tumor markers
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Decide
according to
fertility sparing preference
for surgery and further chemotherapy
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Name of Diagnostic Criteria

It is recommended that you include the criteria in a table. Make sure you always cite the source of the content and whether the table has been adapted from another source.

[Disease name] is primarily diagnosed based on clinical presentation. There are no established criteria for the diagnosis of [disease name].

OR

There is no single diagnostic study of choice for [disease name], though [disease name] may be diagnosed based on [name of criteria] established by [...].

OR

The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].

OR

The diagnosis of [disease name] is based on the [criteria name] criteria, which includes [criterion 1], [criterion 2], and [criterion 3].

OR

[Disease name] may be diagnosed at any time if one or more of the following criteria are met:

  • Criteria 1
  • Criteria 2
  • Criteria 3

OR

IF there are clear, established diagnostic criteria

The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].

OR

The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].

OR

The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].

OR

IF there are no established diagnostic criteria

There are no established criteria for the diagnosis of [disease name].

References

  1. ↑ Pectasides, D.; Pectasides, E.; Kassanos, D. (2008). "Germ cell tumors of the ovary". Cancer Treatment Reviews. 34 (5): 427–441. doi:10.1016/j.ctrv.2008.02.002. ISSN 0305-7372.
  2. ↑ Low, Jeffrey J.H.; Ilancheran, Arunachalam; Ng, Joseph S. (2012). "Malignant ovarian germ-cell tumours". Best Practice & Research Clinical Obstetrics & Gynaecology. 26 (3): 347–355. doi:10.1016/j.bpobgyn.2012.01.002. ISSN 1521-6934.

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Ovarian_germ_cell_tumor_diagnostic_study_of_choice&oldid=1557961"