RTKN: Difference between revisions

Jump to navigation Jump to search
m (Bot: HTTP→HTTPS)
imported>Jmertel23
m (added wikilinks and removed "underlinked" tag)
 
Line 1: Line 1:
{{Underlinked|date=June 2016}}
 
{{Infobox_gene}}
{{Infobox_gene}}
'''Rhotekin''' is a [[protein]] that in humans is encoded by the ''RTKN'' [[gene]].<ref name="pmid9073523">{{cite journal | vauthors = Jang W, Weber JS, Harkins EB, Meisler MH | title = Localization of the rhotekin gene RTKN on the physical maps of mouse chromosome 6 and human chromosome 2p13 and exclusion as a candidate for mnd2 and LGMD2B | journal = Genomics | volume = 40 | issue = 3 | pages = 506–7 |date=May 1997 | pmid = 9073523 | pmc =  | doi = 10.1006/geno.1996.4593 }}</ref><ref name="pmid10940294">{{cite journal | vauthors = Reynaud C, Fabre S, Jalinot P | title = The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element | journal = J Biol Chem | volume = 275 | issue = 43 | pages = 33962–8 |date=Nov 2000 | pmid = 10940294 | pmc =  | doi = 10.1074/jbc.M000465200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RTKN rhotekin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6242| accessdate = }}</ref>
'''Rhotekin''' is a [[protein]] that in humans is encoded by the ''RTKN'' [[gene]].<ref name="pmid9073523">{{cite journal | vauthors = Jang W, Weber JS, Harkins EB, Meisler MH | title = Localization of the rhotekin gene RTKN on the physical maps of mouse chromosome 6 and human chromosome 2p13 and exclusion as a candidate for mnd2 and LGMD2B | journal = Genomics | volume = 40 | issue = 3 | pages = 506–7 |date=May 1997 | pmid = 9073523 | pmc =  | doi = 10.1006/geno.1996.4593 }}</ref><ref name="pmid10940294">{{cite journal | vauthors = Reynaud C, Fabre S, Jalinot P | title = The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element | journal = J Biol Chem | volume = 275 | issue = 43 | pages = 33962–8 |date=Nov 2000 | pmid = 10940294 | pmc =  | doi = 10.1074/jbc.M000465200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RTKN rhotekin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6242| accessdate = }}</ref>
Line 6: Line 6:
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez"/>
| summary_text = This gene encodes a [[scaffold protein]] that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the [[GTPase]] activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including [[cytokinesis]], [[transcription (biology)|transcription]], [[muscle contraction|smooth muscle contraction]], [[cell growth]] and transformation. Dysregulation of the Rho [[signal transduction pathway]] has been implicated in many forms of [[cancer]]. Alternative splicing results in multiple transcript variants encoding different [[isoforms]].<ref name="entrez"/>
}}
}}



Latest revision as of 19:21, 19 February 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rhotekin is a protein that in humans is encoded by the RTKN gene.[1][2][3]

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]

References

  1. Jang W, Weber JS, Harkins EB, Meisler MH (May 1997). "Localization of the rhotekin gene RTKN on the physical maps of mouse chromosome 6 and human chromosome 2p13 and exclusion as a candidate for mnd2 and LGMD2B". Genomics. 40 (3): 506–7. doi:10.1006/geno.1996.4593. PMID 9073523.
  2. Reynaud C, Fabre S, Jalinot P (Nov 2000). "The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element". J Biol Chem. 275 (43): 33962–8. doi:10.1074/jbc.M000465200. PMID 10940294.
  3. 3.0 3.1 "Entrez Gene: RTKN rhotekin".

Further reading