ATP5I: Difference between revisions

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'''ATP synthase subunit e, mitochondrial''' is an [[enzyme]] that in humans is encoded by the ''ATP5I'' [[gene]].<ref name="pmid8702853">{{cite journal | vauthors = Swartz DA, Park EI, Visek WJ, Kaput J | title = The e subunit gene of murine F1F0-ATP synthase. Genomic sequence, chromosomal mapping, and diet regulation | journal = J Biol Chem | volume = 271 | issue = 34 | pages = 20942–8 |date=Oct 1996 | pmid = 8702853 | pmc =  | doi =10.1074/jbc.271.34.20942  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP5I ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=521| accessdate = }}</ref>
'''ATP synthase subunit e, mitochondrial''' is an [[enzyme]] that in humans is encoded by the ''ATP5ME'' [[gene]].<ref name="pmid8702853">{{cite journal | vauthors = Swartz DA, Park EI, Visek WJ, Kaput J | title = The e subunit gene of murine F1F0-ATP synthase. Genomic sequence, chromosomal mapping, and diet regulation | journal = J Biol Chem | volume = 271 | issue = 34 | pages = 20942–8 |date=Oct 1996 | pmid = 8702853 | pmc =  | doi =10.1074/jbc.271.34.20942  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP5ME ATP synthase membrane subunit e| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=521| accessdate = }}</ref>


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| summary_text = Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F0 seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the F0 complex.<ref name="entrez" />
| summary_text = Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex.<ref name="entrez" />
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==External links==
==External links==
* {{UCSC gene info|ATP5I}}
* {{UCSC gene info|ATP5ME}}


==Further reading==
==Further reading==

Revision as of 13:48, 21 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
ATP synthase E chain
Identifiers
SymbolATP-synt_E
PfamPF05680
InterProIPR008386
SCOP1e79
SUPERFAMILY1e79

ATP synthase subunit e, mitochondrial is an enzyme that in humans is encoded by the ATP5ME gene.[1][2]

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex.[2]

In yeast, the FO complex E subunit appears to play an important role in supporting F-ATPase dimerisation. This subunit is anchored to the inner mitochondrial membrane via its N-terminal region, which is involved in stabilising subunits G and K of the FO complex. The C-terminal region of subunit E is hydrophilic, protruding into the intermembrane space where it can also help stabilise the F-ATPase dimer complex.[3]

References

  1. ↑ Swartz DA, Park EI, Visek WJ, Kaput J (Oct 1996). "The e subunit gene of murine F1F0-ATP synthase. Genomic sequence, chromosomal mapping, and diet regulation". J Biol Chem. 271 (34): 20942–8. doi:10.1074/jbc.271.34.20942. PMID 8702853.
  2. ↑ 2.0 2.1 "Entrez Gene: ATP5ME ATP synthase membrane subunit e".
  3. ↑ Everard-Gigot V, Dunn CD, Dolan BM, Brunner S, Jensen RE, Stuart RA (February 2005). "Functional analysis of subunit e of the F1Fo-ATP synthase of the yeast Saccharomyces cerevisiae: importance of the N-terminal membrane anchor region". Eukaryotic Cell. 4 (2): 346–55. doi:10.1128/EC.4.2.346-355.2005. PMC 549337. PMID 15701797.

External links

Further reading


This article incorporates text from the public domain Pfam and InterPro: IPR008386


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