RCHY1: Difference between revisions

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== Interactions ==
== Interactions ==


RCHY1 has been shown to [[Protein-protein interaction|interact]] with [[P53]]<ref name=pmid12654245>{{cite journal | vauthors = Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S | title = Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation | journal = Cell | volume = 112 | issue = 6 | pages = 779–91 | date = Mar 2003 | pmid = 12654245 | doi = 10.1016/S0092-8674(03)00193-4 }}</ref><ref name=pmid19043414>{{cite journal | vauthors = Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, Lukin J, Sunnerhagen M, Srisailam S, Karra M, Benchimol S, Arrowsmith CH | title = Molecular basis of Pirh2-mediated p53 ubiquitylation | journal = Nature Structural & Molecular Biology | volume = 15 | issue = 12 | pages = 1334–42 | date = Dec 2008 | pmid = 19043414 | doi = 10.1038/nsmb.1521 }}</ref> and [[Androgen receptor]].<ref name=pmid12200228>{{cite journal | vauthors = Beitel LK, Elhaji YA, Lumbroso R, Wing SS, Panet-Raymond V, Gottlieb B, Pinsky L, Trifiro MA | title = Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity | journal = Journal of Molecular Endocrinology | volume = 29 | issue = 1 | pages = 41–60 | date = Aug 2002 | pmid = 12200228 | doi = 10.1677/jme.0.0290041 }}</ref>
RCHY1 has been shown to [[Protein-protein interaction|interact]] with [[P53]]<ref name=pmid12654245>{{cite journal | vauthors = Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S | title = Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation | journal = Cell | volume = 112 | issue = 6 | pages = 779–91 | date = Mar 2003 | pmid = 12654245 | doi = 10.1016/S0092-8674(03)00193-4 }}</ref><ref name=pmid19043414>{{cite journal | vauthors = Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, Lukin J, Sunnerhagen M, Srisailam S, Karra M, Benchimol S, Arrowsmith CH | title = Molecular basis of Pirh2-mediated p53 ubiquitylation | journal = Nature Structural & Molecular Biology | volume = 15 | issue = 12 | pages = 1334–42 | date = Dec 2008 | pmid = 19043414 | doi = 10.1038/nsmb.1521 | pmc=4075976}}</ref> and [[Androgen receptor]].<ref name=pmid12200228>{{cite journal | vauthors = Beitel LK, Elhaji YA, Lumbroso R, Wing SS, Panet-Raymond V, Gottlieb B, Pinsky L, Trifiro MA | title = Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity | journal = Journal of Molecular Endocrinology | volume = 29 | issue = 1 | pages = 41–60 | date = Aug 2002 | pmid = 12200228 | doi = 10.1677/jme.0.0290041 }}</ref>


== References ==
== References ==

Revision as of 16:06, 9 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

RING finger and CHY zinc finger domain-containing protein 1 is a protein that in humans is encoded by the RCHY1 gene.[1]

Function

The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53. Alternative splicing results in multiple transcript variants encoding different isoforms.[1]

Interactions

RCHY1 has been shown to interact with P53[2][3] and Androgen receptor.[4]

References

  1. 1.0 1.1 "Entrez Gene: RCHY1 ring finger and CHY zinc finger domain containing 1".
  2. Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S (Mar 2003). "Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation". Cell. 112 (6): 779–91. doi:10.1016/S0092-8674(03)00193-4. PMID 12654245.
  3. Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, Lukin J, Sunnerhagen M, Srisailam S, Karra M, Benchimol S, Arrowsmith CH (Dec 2008). "Molecular basis of Pirh2-mediated p53 ubiquitylation". Nature Structural & Molecular Biology. 15 (12): 1334–42. doi:10.1038/nsmb.1521. PMC 4075976. PMID 19043414.
  4. Beitel LK, Elhaji YA, Lumbroso R, Wing SS, Panet-Raymond V, Gottlieb B, Pinsky L, Trifiro MA (Aug 2002). "Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity". Journal of Molecular Endocrinology. 29 (1): 41–60. doi:10.1677/jme.0.0290041. PMID 12200228.

Further reading