ADH1C: Difference between revisions
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{{Infobox_gene}} | {{Infobox_gene}} | ||
'''Alcohol dehydrogenase 1C''' is an [[enzyme]] that in humans is encoded by the ''ADH1C'' [[gene]].<ref name="pmid3006456">{{ | '''Alcohol dehydrogenase 1C''' is an [[enzyme]] that in humans is encoded by the ''ADH1C'' [[gene]].<ref name="pmid3006456">{{Cite book | vauthors = Smith M | title = Genetics of human alcohol and aldehyde dehydrogenases | journal = Advances in Human Genetics | volume = 15 | issue = | pages = 249–90 | date = Mar 1986 | pmid = 3006456 | pmc = | doi = 10.1007/978-1-4615-8356-1_5 | isbn = 978-1-4615-8358-5 }}</ref> | ||
== Function == | == Function == | ||
This gene encodes class I [[alcohol dehydrogenase]], gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, | This gene encodes class I [[alcohol dehydrogenase]], gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol (beverage alcohol), retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibit high activity for ethanol oxidation and play a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.<ref name="entrez">{{cite web | title = Entrez Gene: ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=126| accessdate = }}</ref> | ||
== References == | == References == | ||
{{reflist}} | {{reflist}} | ||
== Further reading == | == Further reading == | ||
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* {{cite journal | vauthors = Duester G, Farrés J, Felder MR, Holmes RS, Höög JO, Parés X, Plapp BV, Yin SJ, Jörnvall H | title = Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family | journal = Biochemical Pharmacology | volume = 58 | issue = 3 | pages = 389–95 | date = Aug 1999 | pmid = 10424757 | doi = 10.1016/S0006-2952(99)00065-9 }} | * {{cite journal | vauthors = Duester G, Farrés J, Felder MR, Holmes RS, Höög JO, Parés X, Plapp BV, Yin SJ, Jörnvall H | title = Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family | journal = Biochemical Pharmacology | volume = 58 | issue = 3 | pages = 389–95 | date = Aug 1999 | pmid = 10424757 | doi = 10.1016/S0006-2952(99)00065-9 }} | ||
* {{cite journal | vauthors = Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD | title = Three-dimensional structures of the three human class I alcohol dehydrogenases | journal = Protein Science | volume = 10 | issue = 4 | pages = 697–706 | date = Apr 2001 | pmid = 11274460 | pmc = 2373965 | doi = 10.1110/ps.45001 }} | * {{cite journal | vauthors = Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD | title = Three-dimensional structures of the three human class I alcohol dehydrogenases | journal = Protein Science | volume = 10 | issue = 4 | pages = 697–706 | date = Apr 2001 | pmid = 11274460 | pmc = 2373965 | doi = 10.1110/ps.45001 }} | ||
* {{cite journal | vauthors = Osier MV, Pakstis AJ, Goldman D, Edenberg HJ, Kidd JR, Kidd KK | title = A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans | journal = Alcoholism: Clinical and Experimental Research | volume = 26 | issue = 12 | pages = 1759–63 | date = Dec 2002 | pmid = 12500098 | doi = 10.1097/01.ALC.0000042013.13899.75 }} | * {{cite journal | vauthors = Osier MV, Pakstis AJ, Goldman D, Edenberg HJ, Kidd JR, Kidd KK | title = A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans | journal = Alcoholism: Clinical and Experimental Research | volume = 26 | issue = 12 | pages = 1759–63 | date = Dec 2002 | pmid = 12500098 | doi = 10.1097/01.ALC.0000042013.13899.75 | doi-broken-date = 2018-11-07 }} | ||
{{refend}} | {{refend}} | ||
==External links== | |||
* {{UCSC gene info|ADH1C}} | |||
{{PDB Gallery|geneid=126}} | {{PDB Gallery|geneid=126}} | ||
{{protein-stub}} | {{protein-stub}} | ||
Revision as of 12:59, 7 November 2018
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Alcohol dehydrogenase 1C is an enzyme that in humans is encoded by the ADH1C gene.[1]
Function
This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol (beverage alcohol), retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibit high activity for ethanol oxidation and play a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.[2]
References
- ↑ Smith M (Mar 1986). Genetics of human alcohol and aldehyde dehydrogenases. Advances in Human Genetics. 15. pp. 249–90. doi:10.1007/978-1-4615-8356-1_5. ISBN 978-1-4615-8358-5. PMID 3006456.
- ↑ "Entrez Gene: ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide".
Further reading
- Seitz HK, Meier P (Jun 2007). "The role of acetaldehyde in upper digestive tract cancer in alcoholics". Translational Research. 149 (6): 293–7. doi:10.1016/j.trsl.2006.12.002. PMID 17543846.
- Lange LG, Sytkowski AJ, Vallee BL (Oct 1976). "Human liver alcohol dehydrogenase: purification, composition, and catalytic features". Biochemistry. 15 (21): 4687–93. doi:10.1021/bi00666a023. PMID 9982.
- Yokoyama S, Matsuo Y, Rajasekharan S, Yokoyama R (Apr 1992). "Molecular structure of the human alcohol dehydrogenase 3 gene". Idengaku Zasshi. 67 (2): 167–71. doi:10.1266/jjg.67.167. PMID 1524834.
- Hurley TD, Bosron WF, Hamilton JA, Amzel LM (Sep 1991). "Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions". Proceedings of the National Academy of Sciences of the United States of America. 88 (18): 8149–53. doi:10.1073/pnas.88.18.8149. PMC 52464. PMID 1896463.
- Stewart MJ, McBride MS, Winter LA, Duester G (Jun 1990). "Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3: interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box". Gene. 90 (2): 271–9. doi:10.1016/0378-1119(90)90190-3. PMID 2169444.
- Yasunami M, Kikuchi I, Sarapata D, Yoshida A (Jun 1990). "The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome". Genomics. 7 (2): 152–8. doi:10.1016/0888-7543(90)90535-3. PMID 2347582.
- Tsukahara M, Yoshida A (Feb 1989). "Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization". Genomics. 4 (2): 218–20. doi:10.1016/0888-7543(89)90304-2. PMID 2737681.
- Ikuta T, Szeto S, Yoshida A (Feb 1986). "Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence". Proceedings of the National Academy of Sciences of the United States of America. 83 (3): 634–8. doi:10.1073/pnas.83.3.634. PMC 322918. PMID 2935875.
- Xu YL, Carr LG, Bosron WF, Li TK, Edenberg HJ (Apr 1988). "Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification". Genomics. 2 (3): 209–14. doi:10.1016/0888-7543(88)90004-3. PMID 3397059.
- Höög JO, Hedén LO, Larsson K, Jörnvall H, von Bahr-Lindström H (Sep 1986). "The gamma 1 and gamma 2 subunits of human liver alcohol dehydrogenase. cDNA structures, two amino acid replacements, and compatibility with changes in the enzymatic properties". European Journal of Biochemistry / FEBS. 159 (2): 215–8. doi:10.1111/j.1432-1033.1986.tb09855.x. PMID 3758060.
- Bühler R, Hempel J, Kaiser R, de Zalenski C, von Wartburg JP, Jörnvall H (Dec 1984). "Human liver alcohol dehydrogenase. 2. The primary structure of the gamma 1 protein chain". European Journal of Biochemistry / FEBS. 145 (3): 447–53. doi:10.1111/j.1432-1033.1984.tb08575.x. PMID 6391921.
- Cheung B, Anderson JK, Holmes RS, Beacham IR (Feb 1995). "Human stomach class IV alcohol dehydrogenase: molecular genetic analysis". Alcoholism: Clinical and Experimental Research. 19 (1): 185–6. doi:10.1111/j.1530-0277.1995.tb01490.x. PMID 7771649.
- Hurley TD, Bosron WF, Stone CL, Amzel LM (Jun 1994). "Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences". Journal of Molecular Biology. 239 (3): 415–29. doi:10.1006/jmbi.1994.1382. PMID 8201622.
- Cheung C, Smith CK, Hoog JO, Hotchkiss SA (Jul 1999). "Expression and localization of human alcohol and aldehyde dehydrogenase enzymes in skin". Biochemical and Biophysical Research Communications. 261 (1): 100–7. doi:10.1006/bbrc.1999.0943. PMID 10405330.
- Duester G, Farrés J, Felder MR, Holmes RS, Höög JO, Parés X, Plapp BV, Yin SJ, Jörnvall H (Aug 1999). "Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family". Biochemical Pharmacology. 58 (3): 389–95. doi:10.1016/S0006-2952(99)00065-9. PMID 10424757.
- Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD (Apr 2001). "Three-dimensional structures of the three human class I alcohol dehydrogenases". Protein Science. 10 (4): 697–706. doi:10.1110/ps.45001. PMC 2373965. PMID 11274460.
- Osier MV, Pakstis AJ, Goldman D, Edenberg HJ, Kidd JR, Kidd KK (Dec 2002). "A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans". Alcoholism: Clinical and Experimental Research. 26 (12): 1759–63. doi:10.1097/01.ALC.0000042013.13899.75 (inactive 2018-11-07). PMID 12500098.
External links
- Human ADH1C genome location and ADH1C gene details page in the UCSC Genome Browser.
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