LARP6: Difference between revisions
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'''La-related protein 6''' also known as '''acheron''' or '''La ribonucleoprotein domain family member 6''' (LARP6), is a [[protein]] that in humans is encoded by the ''LARP6'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: La ribonucleoprotein domain family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55323| accessdate = }}</ref> | '''La-related protein 6''' also known as '''acheron''' or '''La ribonucleoprotein domain family member 6''' (LARP6), is a [[protein]] that in humans is encoded by the ''LARP6'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: La ribonucleoprotein domain family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55323| accessdate = }}</ref> | ||
==Clinical relevance== | ==Clinical relevance== | ||
In a recent genome-wide association study, LARP6 gene has been associated with fasting glucose traits, type 2 diabetes and obesity.<ref name="pmid21873549">{{cite journal |vauthors=Strawbridge RJ, Dupuis J, Prokopenko I, etal | title = Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes | journal = Diabetes | volume = 60| issue = 10| pages = 2624–34|date=August 2011 | pmid = 21873549 | doi = 10.2337/db11-0415 | pmc=3178302}}</ref> | In a recent [[genome-wide association study]], LARP6 gene has been associated with fasting [[glucose]] traits, [[Diabetes mellitus type 2|type 2 diabetes]] and [[obesity]].<ref name="pmid21873549">{{cite journal |vauthors=Strawbridge RJ, [[Josée Dupuis|Dupuis J]], Prokopenko I, etal | title = Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes | journal = Diabetes | volume = 60| issue = 10| pages = 2624–34|date=August 2011 | pmid = 21873549 | doi = 10.2337/db11-0415 | pmc=3178302}}</ref> | ||
==References== | ==References== | ||
Revision as of 01:33, 16 December 2018
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La-related protein 6 also known as acheron or La ribonucleoprotein domain family member 6 (LARP6), is a protein that in humans is encoded by the LARP6 gene.[1]
Clinical relevance
In a recent genome-wide association study, LARP6 gene has been associated with fasting glucose traits, type 2 diabetes and obesity.[2]
References
- ↑ "Entrez Gene: La ribonucleoprotein domain family".
- ↑ Strawbridge RJ, Dupuis J, Prokopenko I, et al. (August 2011). "Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes". Diabetes. 60 (10): 2624–34. doi:10.2337/db11-0415. PMC 3178302. PMID 21873549.
Further reading
- Cai L, Fritz D, Stefanovic L, Stefanovic B (2010). "Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen". J. Mol. Biol. 395 (2): 309–26. doi:10.1016/j.jmb.2009.11.020. PMC 2826804. PMID 19917293.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Glenn HL, Wang Z, Schwartz LM (2010). "Acheron, a Lupus antigen family member, regulates integrin expression, adhesion, and motility in differentiating myoblasts". Am. J. Physiol., Cell Physiol. 298 (1): C46–55. doi:10.1152/ajpcell.00387.2009. PMC 2806151. PMID 19889961.
- Valavanis C, Wang Z, Sun D, et al. (2007). "Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta". Gene. 393 (1–2): 101–9. doi:10.1016/j.gene.2007.01.033. PMC 2739619. PMID 17383118.
- Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
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