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Revision as of 14:39, 2 February 2018

Colitis Main Page

Ischemic colitis Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Ischemic colitis from other Diseases

Epidemiology and Demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Hamid Qazi, MD, BSc [2]

Overview

Ischemic colitis is the result of a sudden reduction in blood flow that is insufficient to meet the metabolic demands of the region of colon. Ischemic change will subsequently extend from the mucosa to the serosa. Mucosal injury will develop in 20 minutes to 1 hour and transmural infarction occurs within 8 to 16 hours. Reperfusion injury can occur with the release of reactive oxygen species, which cause lipid peroxidation within cell membranes, causing cell necrosis.

Physiology

Colonic Blood Supply

Pathophysiology

The pathophysiology of ischemic colitis is as follows:[2][3][4]

Development of Ischemia

Microscopic Pathology

Images

By Nephron Micrograph of a colonic pseudomembrane, a finding that may be associated with ischemic colitis. H&E stain.Source: Own work, CC BY-SA 3.0

Videos

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References

  1. Rosenblum JD, Boyle CM, Schwartz LB (1997). "The mesenteric circulation. Anatomy and physiology". Surg Clin North Am. 77 (2): 289–306. PMID 9146713.
  2. Granger DN, Rutili G, McCord JM (1981). "Superoxide radicals in feline intestinal ischemia". Gastroenterology. 81 (1): 22–9. PMID 6263743.
  3. Brandt LJ, Boley SJ, Goldberg L, et al: Colitis in the elderly. Am J Gastroenterol 76:239, 1981.
  4. Washington, Christopher; Carmichael, Joseph (2012). "Management of Ischemic Colitis". Clinics in Colon and Rectal Surgery. 25 (04): 228–235. doi:10.1055/s-0032-1329534. ISSN 1531-0043.

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