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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein unc-13 homolog B''' is a [[protein]] that in humans is encoded by the ''UNC13B'' [[gene]].<ref name="pmid9607201">{{cite journal | vauthors = Song Y, Ailenberg M, Silverman M | title = Cloning of a novel gene in the human kidney homologous to rat munc13s: its potential role in diabetic nephropathy | journal = Kidney Int | volume = 53 | issue = 6 | pages = 1689–95 | date = August 1998 | pmid = 9607201 | pmc =  | doi = 10.1046/j.1523-1755.1998.00942.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UNC13B unc-13 homolog B (C. elegans)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10497| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Unc-13 homolog B (C. elegans)
| HGNCid = 12566
| Symbol = UNC13B
| AltSymbols =; MGC133279; MGC133280; MUNC13; UNC13; Unc13h2; hmunc13
| OMIM = 605836
| ECnumber = 
| Homologene = 31376
| MGIid = 1342278
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}}
| Process = {{GNF_GO|id=GO:0006887 |text = exocytosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007588 |text = excretion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10497
    | Hs_Ensembl = ENSG00000198722
    | Hs_RefseqProtein = NP_006368
    | Hs_RefseqmRNA = NM_006377
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 35152006
    | Hs_GenLoc_end = 35395331
    | Hs_Uniprot = O14795
    | Mm_EntrezGene = 22249
    | Mm_Ensembl = ENSMUSG00000028456
    | Mm_RefseqmRNA = XM_973550
    | Mm_RefseqProtein = XP_978644
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 43108981
    | Mm_GenLoc_end = 43285970
    | Mm_Uniprot = Q3TTZ7
  }}
}}
'''Unc-13 homolog B (C. elegans)''', also known as '''UNC13B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UNC13B unc-13 homolog B (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10497| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.<ref name="entrez">{{cite web | title = Entrez Gene: UNC13B unc-13 homolog B (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10497| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Betz A, Okamoto M, Benseler F, Brose N |title=Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin. |journal=J. Biol. Chem. |volume=272 |issue= 4 |pages= 2520-6 |year= 1997 |pmid= 8999968 |doi=  }}
*{{cite journal  | author=Orita S, Naito A, Sakaguchi G, ''et al.'' |title=Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery. |journal=J. Biol. Chem. |volume=272 |issue= 26 |pages= 16081-4 |year= 1997 |pmid= 9195900 |doi=  }}
*{{cite journal  | author=Song Y, Ailenberg M, Silverman M |title=Cloning of a novel gene in the human kidney homologous to rat munc13s: its potential role in diabetic nephropathy. |journal=Kidney Int. |volume=53 |issue= 6 |pages= 1689-95 |year= 1998 |pmid= 9607201 |doi= 10.1046/j.1523-1755.1998.00942.x }}
*{{cite journal  | author=Sakaguchi G, Orita S, Naito A, ''et al.'' |title=A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13. |journal=Biochem. Biophys. Res. Commun. |volume=248 |issue= 3 |pages= 846-51 |year= 1998 |pmid= 9704016 |doi= 10.1006/bbrc.1998.9067 }}
*{{cite journal  | author=Mochida S, Orita S, Sakaguchi G, ''et al.'' |title=Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11418-22 |year= 1998 |pmid= 9736751 |doi=  }}
*{{cite journal  | author=Song Y, Ailenberg M, Silverman M |title=Human munc13 is a diacylglycerol receptor that induces apoptosis and may contribute to renal cell injury in hyperglycemia. |journal=Mol. Biol. Cell |volume=10 |issue= 5 |pages= 1609-19 |year= 1999 |pmid= 10233166 |doi=  }}
*{{cite journal  | author=Duncan RR, Betz A, Shipston MJ, ''et al.'' |title=Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 27347-50 |year= 1999 |pmid= 10488064 |doi=  }}
*{{cite journal  | author=Betz A, Thakur P, Junge HJ, ''et al.'' |title=Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming. |journal=Neuron |volume=30 |issue= 1 |pages= 183-96 |year= 2001 |pmid= 11343654 |doi=  }}
*{{cite journal  | author=Schoch S, Castillo PE, Jo T, ''et al.'' |title=RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. |journal=Nature |volume=415 |issue= 6869 |pages= 321-6 |year= 2002 |pmid= 11797009 |doi= 10.1038/415321a }}
*{{cite journal  | author=Ohtsuka T, Takao-Rikitsu E, Inoue E, ''et al.'' |title=Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1. |journal=J. Cell Biol. |volume=158 |issue= 3 |pages= 577-90 |year= 2002 |pmid= 12163476 |doi= 10.1083/jcb.200202083 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Sheu L, Pasyk EA, Ji J, ''et al.'' |title=Regulation of insulin exocytosis by Munc13-1. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 27556-63 |year= 2003 |pmid= 12871971 |doi= 10.1074/jbc.M303203200 }}
*{{cite journal  | author=Cheviet S, Coppola T, Haynes LP, ''et al.'' |title=The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis. |journal=Mol. Endocrinol. |volume=18 |issue= 1 |pages= 117-26 |year= 2004 |pmid= 14593078 |doi= 10.1210/me.2003-0300 }}
*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal  | author=Yamamoto K, Ishii E, Sako M, ''et al.'' |title=Identification of novel MUNC13-4 mutations in familial haemophagocytic lymphohistiocytosis and functional analysis of MUNC13-4-deficient cytotoxic T lymphocytes. |journal=J. Med. Genet. |volume=41 |issue= 10 |pages= 763-7 |year= 2005 |pmid= 15466010 |doi= 10.1136/jmg.2004.021121 }}
*{{cite journal  | author=Speight P, Silverman M |title=Diacylglycerol-activated Hmunc13 serves as an effector of the GTPase Rab34. |journal=Traffic |volume=6 |issue= 10 |pages= 858-65 |year= 2005 |pmid= 16138900 |doi= 10.1111/j.1600-0854.2005.00321.x }}
}}
{{refend}}


{{protein-stub}}
UNC13B has been shown to [[Protein-protein interaction|interact]] with:
{{WikiDoc Sources}}
* [[DOC2A]],<ref name = pmid9195900>{{cite journal | vauthors = Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y | title = Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery | journal = J. Biol. Chem. | volume = 272 | issue = 26 | pages = 16081–4 | date = June 1997 | pmid = 9195900 | doi =  10.1074/jbc.272.26.16081}}</ref><ref name = pmid9736751>{{cite journal | vauthors = Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y | title = Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 19 | pages = 11418–22 | date = September 1998 | pmid = 9736751 | pmc = 21657 | doi =  10.1073/pnas.95.19.11418}}</ref>
* [[RIMS1]],<ref name = pmid11343654>{{cite journal | vauthors = Betz A, Thakur P, Junge HJ, Ashery U, Rhee JS, Scheuss V, Rosenmund C, Rettig J, Brose N | title = Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming | journal = Neuron | volume = 30 | issue = 1 | pages = 183–96 | date = April 2001 | pmid = 11343654 | doi =  10.1016/s0896-6273(01)00272-0}}</ref><ref name = pmid12163476>{{cite journal | vauthors = Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y | title = Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1 | journal = J. Cell Biol. | volume = 158 | issue = 3 | pages = 577–90 | date = August 2002 | pmid = 12163476 | pmc = 2173811 | doi = 10.1083/jcb.200202083 }}</ref>
* [[SPTBN2]],<ref name = pmid9704016>{{cite journal | vauthors = Sakaguchi G, Orita S, Naito A, Maeda M, Igarashi H, Sasaki T, Takai Y | title = A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13 | journal = Biochem. Biophys. Res. Commun. | volume = 248 | issue = 3 | pages = 846–51 | date = July 1998 | pmid = 9704016 | doi = 10.1006/bbrc.1998.9067 }}</ref>
* [[STX1A]],<ref name = pmid8999968/>  and
* [[STX1B]].<ref name = pmid8999968>{{cite journal | vauthors = Betz A, Okamoto M, Benseler F, Brose N | title = Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin | journal = J. Biol. Chem. | volume = 272 | issue = 4 | pages = 2520–6 | date = January 1997 | pmid = 8999968 | doi =  10.1074/jbc.272.4.2520}}</ref>
{{Clear}}
 
== References ==
{{Reflist|35em}}
 
== Further reading ==
{{Refbegin|35em}}
* {{cite journal | vauthors = Betz A, Okamoto M, Benseler F, Brose N | title = Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin | journal = J. Biol. Chem. | volume = 272 | issue = 4 | pages = 2520–6 | year = 1997 | pmid = 8999968 | doi = 10.1074/jbc.272.4.2520 }}
* {{cite journal | vauthors = Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y | title = Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery | journal = J. Biol. Chem. | volume = 272 | issue = 26 | pages = 16081–4 | year = 1997 | pmid = 9195900 | doi = 10.1074/jbc.272.26.16081 }}
* {{cite journal | vauthors = Sakaguchi G, Orita S, Naito A, Maeda M, Igarashi H, Sasaki T, Takai Y | title = A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13 | journal = Biochem. Biophys. Res. Commun. | volume = 248 | issue = 3 | pages = 846–51 | year = 1998 | pmid = 9704016 | doi = 10.1006/bbrc.1998.9067 }}
* {{cite journal | vauthors = Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y | title = Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 19 | pages = 11418–22 | year = 1998 | pmid = 9736751 | pmc = 21657 | doi = 10.1073/pnas.95.19.11418 }}
* {{cite journal | vauthors = Song Y, Ailenberg M, Silverman M | title = Human munc13 Is a Diacylglycerol Receptor that Induces Apoptosis and May Contribute to Renal Cell Injury in Hyperglycemia | journal = Mol. Biol. Cell | volume = 10 | issue = 5 | pages = 1609–19 | year = 1999 | pmid = 10233166 | pmc = 30485 | doi = 10.1091/mbc.10.5.1609 }}
* {{cite journal | vauthors = Duncan RR, Betz A, Shipston MJ, Brose N, Chow RH | title = Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo | journal = J. Biol. Chem. | volume = 274 | issue = 39 | pages = 27347–50 | year = 1999 | pmid = 10488064 | doi = 10.1074/jbc.274.39.27347 }}
* {{cite journal | vauthors = Betz A, Thakur P, Junge HJ, Ashery U, Rhee JS, Scheuss V, Rosenmund C, Rettig J, Brose N | title = Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming | journal = Neuron | volume = 30 | issue = 1 | pages = 183–96 | year = 2001 | pmid = 11343654 | doi = 10.1016/S0896-6273(01)00272-0 }}
* {{cite journal | vauthors = Schoch S, Castillo PE, Jo T, Mukherjee K, Geppert M, Wang Y, Schmitz F, Malenka RC, Südhof TC | title = RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone | journal = Nature | volume = 415 | issue = 6869 | pages = 321–6 | year = 2002 | pmid = 11797009 | doi = 10.1038/415321a }}
* {{cite journal | vauthors = Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y | title = Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1 | journal = J. Cell Biol. | volume = 158 | issue = 3 | pages = 577–90 | year = 2002 | pmid = 12163476 | pmc = 2173811 | doi = 10.1083/jcb.200202083 }}
* {{cite journal | vauthors = Sheu L, Pasyk EA, Ji J, Huang X, Gao X, Varoqueaux F, Brose N, Gaisano HY | title = Regulation of insulin exocytosis by Munc13-1 | journal = J. Biol. Chem. | volume = 278 | issue = 30 | pages = 27556–63 | year = 2003 | pmid = 12871971 | doi = 10.1074/jbc.M303203200 }}
* {{cite journal | vauthors = Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R | title = The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis | journal = Mol. Endocrinol. | volume = 18 | issue = 1 | pages = 117–26 | year = 2004 | pmid = 14593078 | doi = 10.1210/me.2003-0300 }}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions | journal = Genome Res. | volume = 14 | issue = 9 | pages = 1711–8 | year = 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
* {{cite journal | vauthors = Yamamoto K, Ishii E, Sako M, Ohga S, Furuno K, Suzuki N, Ueda I, Imayoshi M, Yamamoto S, Morimoto A, Takada H, Hara T, Imashuku S, Sasazuki T, Yasukawa M | title = Identification of novel MUNC13-4 mutations in familial haemophagocytic lymphohistiocytosis and functional analysis of MUNC13-4-deficient cytotoxic T lymphocytes | journal = J. Med. Genet. | volume = 41 | issue = 10 | pages = 763–7 | year = 2005 | pmid = 15466010 | pmc = 1735600 | doi = 10.1136/jmg.2004.021121 }}
* {{cite journal | vauthors = Speight P, Silverman M | title = Diacylglycerol-activated Hmunc13 serves as an effector of the GTPase Rab34 | journal = Traffic | volume = 6 | issue = 10 | pages = 858–65 | year = 2005 | pmid = 16138900 | doi = 10.1111/j.1600-0854.2005.00321.x }}
{{Refend}}
 
 
{{Gene-9-stub}}

Latest revision as of 02:18, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein unc-13 homolog B is a protein that in humans is encoded by the UNC13B gene.[1][2]

Function

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.[2]

Interactions

UNC13B has been shown to interact with:

References

  1. ↑ Song Y, Ailenberg M, Silverman M (August 1998). "Cloning of a novel gene in the human kidney homologous to rat munc13s: its potential role in diabetic nephropathy". Kidney Int. 53 (6): 1689–95. doi:10.1046/j.1523-1755.1998.00942.x. PMID 9607201.
  2. ↑ 2.0 2.1 "Entrez Gene: UNC13B unc-13 homolog B (C. elegans)".
  3. ↑ Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900.
  4. ↑ Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (September 1998). "Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11418–22. doi:10.1073/pnas.95.19.11418. PMC 21657. PMID 9736751.
  5. ↑ Betz A, Thakur P, Junge HJ, Ashery U, Rhee JS, Scheuss V, Rosenmund C, Rettig J, Brose N (April 2001). "Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming". Neuron. 30 (1): 183–96. doi:10.1016/s0896-6273(01)00272-0. PMID 11343654.
  6. ↑ Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y (August 2002). "Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1". J. Cell Biol. 158 (3): 577–90. doi:10.1083/jcb.200202083. PMC 2173811. PMID 12163476.
  7. ↑ Sakaguchi G, Orita S, Naito A, Maeda M, Igarashi H, Sasaki T, Takai Y (July 1998). "A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13". Biochem. Biophys. Res. Commun. 248 (3): 846–51. doi:10.1006/bbrc.1998.9067. PMID 9704016.
  8. ↑ 8.0 8.1 Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". J. Biol. Chem. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.

Further reading


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