PPP1R11: Difference between revisions

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{{Infobox_gene}}
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'''Protein phosphatase 1 regulatory subunit 11''' is an [[enzyme]] that in humans is encoded by the ''PPP1R11'' [[gene]].<ref name="pmid9843442">{{cite journal | vauthors = Zhang J, Zhang L, Zhao S, Lee EY | title = Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1 | journal = Biochemistry | volume = 37 | issue = 47 | pages = 16728–34 |date=Dec 1998 | pmid = 9843442 | pmc =  | doi = 10.1021/bi981169g }}</ref><ref name="pmid8781118">{{cite journal | vauthors = Giffon T, Lepourcelet M, Pichon L, Jezequel P, Bouric P, Carn G, Pontarotti P, Gall JY, David V | title = Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region | journal = Immunogenetics | volume = 44 | issue = 5 | pages = 331–9 |date=Oct 1996 | pmid = 8781118 | pmc = | doi =10.1007/BF02602777 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6992| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Protein phosphatase 1, regulatory (inhibitor) subunit 11
| HGNCid = 9285
| Symbol = PPP1R11
| AltSymbols =; HCG-V; HCGV; MGC125741; MGC125742; MGC125743; TCTE5; TCTEX5
| OMIM = 606670
| ECnumber =
| Homologene = 32520
| MGIid = 1923747
| GeneAtlas_image1 = PBB_GE_PPP1R11_201500_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004864 |text = protein phosphatase inhibitor activity}}
  | Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}}  
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6992
    | Hs_Ensembl = ENSG00000112498
    | Hs_RefseqProtein = NP_068778
    | Hs_RefseqmRNA = NM_021959
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = c6_COX
    | Hs_GenLoc_start = 30172139
    | Hs_GenLoc_end = 30175254
    | Hs_Uniprot = O60927
    | Mm_EntrezGene = 76497
    | Mm_Ensembl = ENSMUSG00000036398
    | Mm_RefseqmRNA = NM_029632
    | Mm_RefseqProtein = NP_083908
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 36556801
    | Mm_GenLoc_end = 36559727
    | Mm_Uniprot = Q8K1L5
  }}
}}
'''Protein phosphatase 1, regulatory (inhibitor) subunit 11''', also known as '''PPP1R11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6992| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6.<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6992| accessdate = }}</ref>
| summary_text = This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Amadou C, Ribouchon MT, Mattei MG, ''et al.'' |title=Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes. |journal=Genomics |volume=26 |issue= 1 |pages= 9-20 |year= 1995 |pmid= 7782091 |doi=  }}
*{{cite journal   |vauthors=Amadou C, Ribouchon MT, Mattei MG, etal |title=Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes |journal=Genomics |volume=26 |issue= 1 |pages= 9–20 |year= 1995 |pmid= 7782091 |doi=10.1016/0888-7543(95)80077-Y }}
*{{cite journal | author=el Kahloun A, Chauvel B, Mauvieux V, ''et al.'' |title=Localization of seven new genes around the HLA-A locus. |journal=Hum. Mol. Genet. |volume=2 |issue= 1 |pages= 55-60 |year= 1993 |pmid= 8490624 |doi=  }}
*{{cite journal   |vauthors=el Kahloun A, Chauvel B, Mauvieux V, etal |title=Localization of seven new genes around the HLA-A locus |journal=Hum. Mol. Genet. |volume=2 |issue= 1 |pages= 55–60 |year= 1993 |pmid= 8490624 |doi=10.1093/hmg/2.1.55 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal   |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal | author=Giffon T, Lepourcelet M, Pichon L, ''et al.'' |title=Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region. |journal=Immunogenetics |volume=44 |issue= 5 |pages= 331-9 |year= 1996 |pmid= 8781118 |doi=  }}
*{{cite journal   |vauthors=Lepourcelet M, Andrieux N, Giffon T, etal |title=Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence |journal=Genomics |volume=37 |issue= 3 |pages= 316–26 |year= 1997 |pmid= 8938444 |doi=10.1006/geno.1996.0566 }}
*{{cite journal  | author=Lepourcelet M, Andrieux N, Giffon T, ''et al.'' |title=Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence. |journal=Genomics |volume=37 |issue= 3 |pages= 316-26 |year= 1997 |pmid= 8938444 |doi=  }}
*{{cite journal   |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Zhang J, Zhang L, Zhao S, Lee EY |title=Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1. |journal=Biochemistry |volume=37 |issue= 47 |pages= 16728-34 |year= 1998 |pmid= 9843442 |doi= 10.1021/bi981169g }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal   |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Lesage B, Beullens M, Pedelini L, etal |title=A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3 |journal=Biochemistry |volume=46 |issue= 31 |pages= 8909–19 |year= 2007 |pmid= 17630778 |doi= 10.1021/bi7003119 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal | author=Lesage B, Beullens M, Pedelini L, ''et al.'' |title=A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3. |journal=Biochemistry |volume=46 |issue= 31 |pages= 8909-19 |year= 2007 |pmid= 17630778 |doi= 10.1021/bi7003119 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 18:33, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein phosphatase 1 regulatory subunit 11 is an enzyme that in humans is encoded by the PPP1R11 gene.[1][2][3]

This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6.[3]

References

  1. Zhang J, Zhang L, Zhao S, Lee EY (Dec 1998). "Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1". Biochemistry. 37 (47): 16728–34. doi:10.1021/bi981169g. PMID 9843442.
  2. Giffon T, Lepourcelet M, Pichon L, Jezequel P, Bouric P, Carn G, Pontarotti P, Gall JY, David V (Oct 1996). "Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region". Immunogenetics. 44 (5): 331–9. doi:10.1007/BF02602777. PMID 8781118.
  3. 3.0 3.1 "Entrez Gene: PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11".

Further reading