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{{Infobox_gene}}
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'''Radiation-inducible immediate-early gene IEX-1''' is a [[protein]] that in humans is encoded by the ''IER3'' [[gene]].<ref name="pmid8603392">{{cite journal |vauthors=Kondratyev AD, Chung KN, Jung MO | title = Identification and characterization of a radiation-inducible glycosylated human early-response gene | journal = Cancer Res | volume = 56 | issue = 7 | pages = 1498–502 |date=May 1996 | pmid = 8603392 | pmc =  | doi =  }}</ref><ref name="pmid9703517">{{cite journal |vauthors=Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF | title = IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival | journal = Science | volume = 281 | issue = 5379 | pages = 998–1001 |date=Aug 1998 | pmid = 9703517 | pmc =  | doi =10.1126/science.281.5379.998 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Immediate early response 3
| HGNCid = 5392
| Symbol = IER3
| AltSymbols =; PRG1; DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1
| OMIM = 602996
| ECnumber =
| Homologene = 2894
| MGIid = 104814
| GeneAtlas_image1 = PBB_GE_IER3_201631_s_at_tn.png
  | GeneAtlas_image2 = PBB_GE_IER3_208748_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}  
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8870
    | Hs_Ensembl = ENSG00000137331
    | Hs_RefseqProtein = NP_434702
    | Hs_RefseqmRNA = NM_052815
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 30818955
    | Hs_GenLoc_end = 30820303
    | Hs_Uniprot = P46695
    | Mm_EntrezGene = 15937
    | Mm_Ensembl = ENSMUSG00000003541
    | Mm_RefseqmRNA = NM_133662
    | Mm_RefseqProtein = NP_598423
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 35429737
    | Mm_GenLoc_end = 35430969
    | Mm_Uniprot = Q4FJY1
  }}
}}
'''Immediate early response 3''', also known as '''IER3''', is a human [[gene]].


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.<ref name="entrez">{{cite web | title = Entrez Gene: IER3 immediate early response 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8870| accessdate = }}</ref>
| summary_text = This gene functions in the protection of cells from [[Fas ligand|Fas-]] or [[tumor necrosis factor alpha|tumor necrosis factor type alpha]]-induced [[apoptosis]]. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.<ref name="entrez">{{cite web | title = Entrez Gene: IER3 immediate early response 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8870| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Wu MX |title=Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis. |journal=Apoptosis |volume=8 |issue= 1 |pages= 11-8 |year= 2003 |pmid= 12510147 |doi=  }}
*{{cite journal  | author=Wu MX |title=Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis. |journal=Apoptosis |volume=8 |issue= 1 |pages= 11–8 |year= 2003 |pmid= 12510147 |doi=10.1023/A:1021688600370 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Kondratyev AD, Chung KN, Jung MO |title=Identification and characterization of a radiation-inducible glycosylated human early-response gene. |journal=Cancer Res. |volume=56 |issue= 7 |pages= 1498-502 |year= 1996 |pmid= 8603392 |doi=  }}
*{{cite journal   |vauthors=Schäfer H, Trauzold A, Siegel EG, etal |title=PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line. |journal=Cancer Res. |volume=56 |issue= 11 |pages= 2641–8 |year= 1996 |pmid= 8653710 |doi=  }}
*{{cite journal  | author=Schäfer H, Trauzold A, Siegel EG, ''et al.'' |title=PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line. |journal=Cancer Res. |volume=56 |issue= 11 |pages= 2641-8 |year= 1996 |pmid= 8653710 |doi= }}
*{{cite journal  |vauthors=Pietzsch A, Büchler C, Aslanidis C, Schmitz G |title=Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 1 |pages= 4–9 |year= 1997 |pmid= 9196025 |doi= 10.1006/bbrc.1997.6715 }}
*{{cite journal | author=Pietzsch A, Büchler C, Aslanidis C, Schmitz G |title=Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 1 |pages= 4-9 |year= 1997 |pmid= 9196025 |doi= 10.1006/bbrc.1997.6715 }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  |vauthors=Pietzsch A, Büchler C, Schmitz G |title=Genomic organization, promoter cloning, and chromosomal localization of the Dif-2 gene. |journal=Biochem. Biophys. Res. Commun. |volume=245 |issue= 3 |pages= 651–7 |year= 1998 |pmid= 9588170 |doi= 10.1006/bbrc.1998.8500 }}
*{{cite journal | author=Pietzsch A, Büchler C, Schmitz G |title=Genomic organization, promoter cloning, and chromosomal localization of the Dif-2 gene. |journal=Biochem. Biophys. Res. Commun. |volume=245 |issue= 3 |pages= 651-7 |year= 1998 |pmid= 9588170 |doi= 10.1006/bbrc.1998.8500 }}
*{{cite journal   |vauthors=Schäfer H, Diebel J, Arlt A, etal |title=The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB. |journal=FEBS Lett. |volume=436 |issue= 2 |pages= 139–43 |year= 1998 |pmid= 9781666 |doi=10.1016/S0014-5793(98)01109-0  }}
*{{cite journal | author=Wu MX, Ao Z, Prasad KV, ''et al.'' |title=IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival. |journal=Science |volume=281 |issue= 5379 |pages= 998-1001 |year= 1998 |pmid= 9703517 |doi= }}
*{{cite journal   |vauthors=Kobayashi T, Pittelkow MR, Warner GM, etal |title=Regulation of a novel immediate early response gene, IEX-1, in keratinocytes by 1alpha,25-dihydroxyvitamin D3. |journal=Biochem. Biophys. Res. Commun. |volume=251 |issue= 3 |pages= 868–73 |year= 1998 |pmid= 9791001 |doi= 10.1006/bbrc.1998.9556 }}
*{{cite journal | author=Schäfer H, Diebel J, Arlt A, ''et al.'' |title=The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB. |journal=FEBS Lett. |volume=436 |issue= 2 |pages= 139-43 |year= 1998 |pmid= 9781666 |doi= }}
*{{cite journal   |vauthors=Kumar R, Kobayashi T, Warner GM, etal |title=A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytes. |journal=Biochem. Biophys. Res. Commun. |volume=253 |issue= 2 |pages= 336–41 |year= 1999 |pmid= 9878538 |doi= 10.1006/bbrc.1998.9692 }}
*{{cite journal | author=Kobayashi T, Pittelkow MR, Warner GM, ''et al.'' |title=Regulation of a novel immediate early response gene, IEX-1, in keratinocytes by 1alpha,25-dihydroxyvitamin D3. |journal=Biochem. Biophys. Res. Commun. |volume=251 |issue= 3 |pages= 868-73 |year= 1998 |pmid= 9791001 |doi= 10.1006/bbrc.1998.9556 }}
*{{cite journal   |vauthors=Schäfer H, Arlt A, Trauzold A, etal |title=The putative apoptosis inhibitor IEX-1L is a mutant nonspliced variant of p22(PRG1/IEX-1) and is not expressed in vivo. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 1 |pages= 139–45 |year= 1999 |pmid= 10448082 |doi= 10.1006/bbrc.1999.1131 }}
*{{cite journal | author=Kumar R, Kobayashi T, Warner GM, ''et al.'' |title=A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytes. |journal=Biochem. Biophys. Res. Commun. |volume=253 |issue= 2 |pages= 336-41 |year= 1999 |pmid= 9878538 |doi= 10.1006/bbrc.1998.9692 }}
*{{cite journal   |vauthors=Feldmann KA, Pittelkow MR, Roche PC, etal |title=Expression of an immediate early gene, IEX-1, in human tissues. |journal=Histochem. Cell Biol. |volume=115 |issue= 6 |pages= 489–97 |year= 2001 |pmid= 11455449 |doi= 10.1007/s004180100284 }}
*{{cite journal | author=Schäfer H, Arlt A, Trauzold A, ''et al.'' |title=The putative apoptosis inhibitor IEX-1L is a mutant nonspliced variant of p22(PRG1/IEX-1) and is not expressed in vivo. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 1 |pages= 139-45 |year= 1999 |pmid= 10448082 |doi= 10.1006/bbrc.1999.1131 }}
*{{cite journal   |vauthors=Zhang Y, Schlossman SF, Edwards RA, etal |title=Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 2 |pages= 878–83 |year= 2002 |pmid= 11782530 |doi= 10.1073/pnas.022326699  | pmc=117399 }}
*{{cite journal  | author=Feldmann KA, Pittelkow MR, Roche PC, ''et al.'' |title=Expression of an immediate early gene, IEX-1, in human tissues. |journal=Histochem. Cell Biol. |volume=115 |issue= 6 |pages= 489-97 |year= 2001 |pmid= 11455449 |doi= }}
*{{cite journal  |vauthors=Im HJ, Pittelkow MR, Kumar R |title=Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 14612–21 |year= 2002 |pmid= 11844788  | pmc=2895739 |doi= 10.1074/jbc.M109414200 }}
*{{cite journal | author=Zhang Y, Schlossman SF, Edwards RA, ''et al.'' |title=Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 2 |pages= 878-83 |year= 2002 |pmid= 11782530 |doi= 10.1073/pnas.022326699 }}
*{{cite journal   |vauthors=Ohki R, Yamamoto K, Mano H, etal |title=Identification of mechanically induced genes in human monocytic cells by DNA microarrays. |journal=J. Hypertens. |volume=20 |issue= 4 |pages= 685–91 |year= 2002 |pmid= 11910304 |doi=10.1097/00004872-200204000-00026  }}
*{{cite journal  | author=Im HJ, Pittelkow MR, Kumar R |title=Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 14612-21 |year= 2002 |pmid= 11844788 |doi= 10.1074/jbc.M109414200 }}
*{{cite journal  |vauthors=Im HJ, Craig TA, Pittelkow MR, Kumar R |title=Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression. |journal=Oncogene |volume=21 |issue= 23 |pages= 3706–14 |year= 2002 |pmid= 12032839 |doi= 10.1038/sj.onc.1205450 }}
*{{cite journal | author=Ohki R, Yamamoto K, Mano H, ''et al.'' |title=Identification of mechanically induced genes in human monocytic cells by DNA microarrays. |journal=J. Hypertens. |volume=20 |issue= 4 |pages= 685-91 |year= 2002 |pmid= 11910304 |doi= }}
*{{cite journal   |vauthors=Garcia J, Ye Y, Arranz V, etal |title=IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. |journal=EMBO J. |volume=21 |issue= 19 |pages= 5151–63 |year= 2002 |pmid= 12356731 |doi=10.1093/emboj/cdf488  | pmc=129026  }}
*{{cite journal | author=Im HJ, Craig TA, Pittelkow MR, Kumar R |title=Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression. |journal=Oncogene |volume=21 |issue= 23 |pages= 3706-14 |year= 2002 |pmid= 12032839 |doi= 10.1038/sj.onc.1205450 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Garcia J, Ye Y, Arranz V, ''et al.'' |title=IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. |journal=EMBO J. |volume=21 |issue= 19 |pages= 5151-63 |year= 2002 |pmid= 12356731 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 23:36, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3 gene.[1][2]

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.[3]

References

  1. ↑ Kondratyev AD, Chung KN, Jung MO (May 1996). "Identification and characterization of a radiation-inducible glycosylated human early-response gene". Cancer Res. 56 (7): 1498–502. PMID 8603392.
  2. ↑ Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF (Aug 1998). "IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival". Science. 281 (5379): 998–1001. doi:10.1126/science.281.5379.998. PMID 9703517.
  3. ↑ "Entrez Gene: IER3 immediate early response 3".

Further reading



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