Trefoil factor 1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Trefoil factor 1''' is a [[protein]] that in humans is encoded by the ''TFF1'' [[gene]]<ref name="pmid9043862">{{cite journal |vauthors=Gött P, Beck S, Machado JC, Carneiro F, Schmitt H, Blin N | title = Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression | journal = Eur J Hum Genet | volume = 4 | issue = 6 | pages = 308–15 | date = May 1997 | pmid = 9043862 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TFF1 trefoil factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7031| accessdate = }}</ref> (also called ''pS2'' gene<ref>{{cite journal |vauthors=Chatagnon A, Ballestar E, Esteller M, Dante R | title = A Role for Methyl-CpG Binding Domain Protein 2 in the Modulation of the Estrogen Response of pS2/TFF1 Gene | journal = PLoS ONE | volume = 5 | issue = 3 | pages = e9665 | pmid = 20300195 | doi = 10.1371/journal.pone.0009665 | pmc=2837351 | year=2010}}</ref>).
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_TFF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hi7.
| PDB = {{PDB2|1hi7}}, {{PDB2|1ps2}}
| Name = Trefoil factor 1
| HGNCid = 11755
| Symbol = TFF1
| AltSymbols =; BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2
| OMIM = 113710
| ECnumber = 
| Homologene = 2426
| MGIid = 88135
| GeneAtlas_image1 = PBB_GE_TFF1_205009_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component =
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7031
    | Hs_Ensembl = ENSG00000160182
    | Hs_RefseqProtein = NP_003216
    | Hs_RefseqmRNA = NM_003225
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 42655462
    | Hs_GenLoc_end = 42659713
    | Hs_Uniprot = P04155
    | Mm_EntrezGene = 21784
    | Mm_Ensembl = ENSMUSG00000024032
    | Mm_RefseqmRNA = NM_009362
    | Mm_RefseqProtein = NP_033388
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 30872609
    | Mm_GenLoc_end = 30892065
    | Mm_Uniprot = Q149Y8
  }}
}}
'''Trefoil factor 1''', also known as '''TFF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TFF1 trefoil factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7031| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Members of the trefoil family are characterized by having at least one copy of the [[trefoil domain|trefoil motif]], a 40-amino acid domain that contains three conserved [[disulfide]]s. They are stable secretory proteins expressed in [[gastrointestinal]] [[mucous membrane|mucosa]]. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
===In gastric carcinoma===
| summary_text = Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.<ref name="entrez">{{cite web | title = Entrez Gene: TFF1 trefoil factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7031| accessdate = }}</ref>
 
}}
TFF1 expression is frequently lost in [[gastric carcinoma]], probably through mechanism of DNA methylation, and it is therefore considered as a tumor suppressor gene.<ref name=" pmid = 24190027 ">{{cite journal |vauthors=Feng G, Zhang Y, Yuan H, Bai R, Zheng J, Zhang J, Song M | title = DNA methylation of trefoil factor 1 (TFF1) is associated with the tumorigenesis of gastric carcinoma. | journal = J Mol Med Rep | volume = 9 | issue = 1 | pages = 109–117 | date = Jan 2014 | pmid = 24190027 | doi = 10.3892/mmr.2013.1772 | url = http://www.spandidos-publications.com/mmr/9/1/109 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin}}
{{PBB_Further_reading
*{{cite journal |vauthors=Langer G, Jagla W, Behrens-Baumann W, Walter S, Hoffmann W | title = Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells. | journal = Adv. Exp. Med. Biol. | volume = 506 | issue = Pt A | pages = 313–6 | year = 2003 | pmid = 12613926 | doi =  }}
| citations =
*{{cite journal |vauthors=Piggott NH, Henry JA, May FE, Westley BR | title = Antipeptide antibodies against the pNR-2 oestrogen-regulated protein of human breast cancer cells and detection of pNR-2 expression in normal tissues by immunohistochemistry. | journal = J. Pathol. | volume = 163 | issue = 2 | pages = 95–104 | year = 1991 | pmid = 1707960 | doi = 10.1002/path.1711630204 }}
*{{cite journal | author=Langer G, Jagla W, Behrens-Baumann W, ''et al.'' |title=Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells. |journal=Adv. Exp. Med. Biol. |volume=506 |issue= Pt A |pages= 313-6 |year= 2003 |pmid= 12613926 |doi=  }}
*{{cite journal |vauthors=Mori K, Fujii R, Kida N, Takahashi H, Ohkubo S, Fujino M, Ohta M, Hayashi K | title = Complete primary structure of the human estrogen-responsive gene (pS2) product. | journal = J. Biochem. | volume = 107 | issue = 1 | pages = 73–6 | year = 1990 | pmid = 2185238 | doi =  }}
*{{cite journal | author=Piggott NH, Henry JA, May FE, Westley BR |title=Antipeptide antibodies against the pNR-2 oestrogen-regulated protein of human breast cancer cells and detection of pNR-2 expression in normal tissues by immunohistochemistry. |journal=J. Pathol. |volume=163 |issue= 2 |pages= 95-104 |year= 1991 |pmid= 1707960 |doi= 10.1002/path.1711630204 }}
*{{cite journal |vauthors=Tomasetto C, Rio MC, Gautier C, Wolf C, Hareuveni M, Chambon P, Lathe R | title = hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. | journal = EMBO J. | volume = 9 | issue = 2 | pages = 407–14 | year = 1990 | pmid = 2303034 | pmc = 551681 | doi =  }}
*{{cite journal | author=Mori K, Fujii R, Kida N, ''et al.'' |title=Complete primary structure of the human estrogen-responsive gene (pS2) product. |journal=J. Biochem. |volume=107 |issue= 1 |pages= 73-6 |year= 1990 |pmid= 2185238 |doi=  }}
*{{cite journal |vauthors=Takahashi H, Kida N, Fujii R, Tanaka K, Ohta M, Mori K, Hayashi K | title = Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma. | journal = FEBS Lett. | volume = 261 | issue = 2 | pages = 283–6 | year = 1990 | pmid = 2311759 | doi = 10.1016/0014-5793(90)80572-Z }}
*{{cite journal | author=Tomasetto C, Rio MC, Gautier C, ''et al.'' |title=hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. |journal=EMBO J. |volume=9 |issue= 2 |pages= 407-14 |year= 1990 |pmid= 2303034 |doi=  }}
*{{cite journal |vauthors=Rio MC, Bellocq JP, Daniel JY, Tomasetto C, Lathe R, Chenard MP, Batzenschlager A, Chambon P | title = Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. | journal = Science | volume = 241 | issue = 4866 | pages = 705–8 | year = 1988 | pmid = 3041593 | doi = 10.1126/science.3041593 }}
*{{cite journal | author=Takahashi H, Kida N, Fujii R, ''et al.'' |title=Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma. |journal=FEBS Lett. |volume=261 |issue= 2 |pages= 283-6 |year= 1990 |pmid= 2311759 |doi= }}
*{{cite journal |vauthors=Rio MC, Lepage P, Diemunsch P, Roitsch C, Chambon P | title = [Primary structure of human protein pS2] | journal = C. R. Acad. Sci. III, Sci. Vie | volume = 307 | issue = 19 | pages = 825–31 | year = 1989 | pmid = 3146413 | doi =  }}
*{{cite journal | author=Rio MC, Bellocq JP, Daniel JY, ''et al.'' |title=Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. |journal=Science |volume=241 |issue= 4866 |pages= 705-8 |year= 1988 |pmid= 3041593 |doi= }}
*{{cite journal |vauthors=Mori K, Fujii R, Kida N, Ohta M, Hayashi K | title = Identification of a polypeptide secreted by human breast cancer cells (MCF-7) as the human estrogen-responsive gene (pS2) product. | journal = Biochem. Biophys. Res. Commun. | volume = 155 | issue = 1 | pages = 366–72 | year = 1988 | pmid = 3261981 | doi = 10.1016/S0006-291X(88)81094-5 }}
*{{cite journal | author=Rio MC, Lepage P, Diemunsch P, ''et al.'' |title=[Primary structure of human protein pS2] |journal=C. R. Acad. Sci. III, Sci. Vie |volume=307 |issue= 19 |pages= 825-31 |year= 1989 |pmid= 3146413 |doi=  }}
*{{cite journal |vauthors=Jeltsch JM, Roberts M, Schatz C, Garnier JM, Brown AM, Chambon P | title = Structure of the human oestrogen-responsive gene pS2. | journal = Nucleic Acids Res. | volume = 15 | issue = 4 | pages = 1401–14 | year = 1987 | pmid = 3822834 | pmc = 340557 | doi = 10.1093/nar/15.4.1401 }}
*{{cite journal | author=Mori K, Fujii R, Kida N, ''et al.'' |title=Identification of a polypeptide secreted by human breast cancer cells (MCF-7) as the human estrogen-responsive gene (pS2) product. |journal=Biochem. Biophys. Res. Commun. |volume=155 |issue= 1 |pages= 366-72 |year= 1988 |pmid= 3261981 |doi= }}
*{{cite journal |vauthors=Prud'homme JF, Fridlansky F, Le Cunff M, Atger M, Mercier-Bodart C, Pichon MF, Milgrom E | title = Cloning of a gene expressed in human breast cancer and regulated by estrogen in MCF-7 cells. | journal = DNA | volume = 4 | issue = 1 | pages = 11–21 | year = 1985 | pmid = 3838275 | doi = 10.1089/dna.1985.4.11 }}
*{{cite journal | author=Jeltsch JM, Roberts M, Schatz C, ''et al.'' |title=Structure of the human oestrogen-responsive gene pS2. |journal=Nucleic Acids Res. |volume=15 |issue= 4 |pages= 1401-14 |year= 1987 |pmid= 3822834 |doi= }}
*{{cite journal |vauthors=Jakowlew SB, Breathnach R, Jeltsch JM, Masiakowski P, Chambon P | title = Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7. | journal = Nucleic Acids Res. | volume = 12 | issue = 6 | pages = 2861–78 | year = 1984 | pmid = 6324130 | pmc = 318711 | doi = 10.1093/nar/12.6.2861 }}
*{{cite journal | author=Prud'homme JF, Fridlansky F, Le Cunff M, ''et al.'' |title=Cloning of a gene expressed in human breast cancer and regulated by estrogen in MCF-7 cells. |journal=DNA |volume=4 |issue= 1 |pages= 11-21 |year= 1985 |pmid= 3838275 |doi= }}
*{{cite journal |vauthors=Hanby AM, Poulsom R, Singh S, Elia G, Jeffery RE, Wright NA | title = Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. | journal = Gastroenterology | volume = 105 | issue = 4 | pages = 1110–6 | year = 1993 | pmid = 8405856 | doi =  }}
*{{cite journal | author=Jakowlew SB, Breathnach R, Jeltsch JM, ''et al.'' |title=Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7. |journal=Nucleic Acids Res. |volume=12 |issue= 6 |pages= 2861-78 |year= 1984 |pmid= 6324130 |doi= }}
*{{cite journal |vauthors=Polshakov VI, Frenkiel TA, Westley B, Chadwick M, May F, Carr MD, Feeney J | title = NMR-based structural studies of the pNR-2/pS2 single domain trefoil peptide. Similarities to porcine spasmolytic peptide and evidence for a monomeric structure. | journal = Eur. J. Biochem. | volume = 233 | issue = 3 | pages = 847–55 | year = 1996 | pmid = 8521850 | doi = 10.1111/j.1432-1033.1995.847_3.x }}
*{{cite journal | author=Hanby AM, Poulsom R, Singh S, ''et al.'' |title=Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. |journal=Gastroenterology |volume=105 |issue= 4 |pages= 1110-6 |year= 1993 |pmid= 8405856 |doi=  }}
*{{cite journal |vauthors=Seib T, Blin N, Hilgert K, Seifert M, Theisinger B, Engel M, Dooley S, Zang KD, Welter C | title = The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. | journal = Genomics | volume = 40 | issue = 1 | pages = 200–2 | year = 1997 | pmid = 9070946 | doi = 10.1006/geno.1996.4511 }}
*{{cite journal | author=Polshakov VI, Frenkiel TA, Westley B, ''et al.'' |title=NMR-based structural studies of the pNR-2/pS2 single domain trefoil peptide. Similarities to porcine spasmolytic peptide and evidence for a monomeric structure. |journal=Eur. J. Biochem. |volume=233 |issue= 3 |pages= 847-55 |year= 1996 |pmid= 8521850 |doi= }}
*{{cite journal |vauthors=Polshakov VI, Williams MA, Gargaro AR, Frenkiel TA, Westley BR, Chadwick MP, May FE, Feeney J | title = High-resolution solution structure of human pNR-2/pS2: a single trefoil motif protein. | journal = J. Mol. Biol. | volume = 267 | issue = 2 | pages = 418–32 | year = 1997 | pmid = 9096235 | doi = 10.1006/jmbi.1997.0896 }}
*{{cite journal | author=Gött P, Beck S, Machado JC, ''et al.'' |title=Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. |journal=Eur. J. Hum. Genet. |volume=4 |issue= 6 |pages= 308-15 |year= 1997 |pmid= 9043862 |doi= }}
*{{cite journal |vauthors=Chadwick MP, Westley BR, May FE | title = Homodimerization and hetero-oligomerization of the single-domain trefoil protein pNR-2/pS2 through cysteine 58. | journal = Biochem. J. | volume = 327 | issue = 1 | pages = 117–23 | year = 1997 | pmid = 9355742 | pmc = 1218770 | doi = }}
*{{cite journal | author=Seib T, Blin N, Hilgert K, ''et al.'' |title=The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. |journal=Genomics |volume=40 |issue= 1 |pages= 200-2 |year= 1997 |pmid= 9070946 |doi= 10.1006/geno.1996.4511 }}
*{{cite journal |vauthors=Chen H, Lin RJ, Xie W, Wilpitz D, Evans RM | title = Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. | journal = Cell | volume = 98 | issue = 5 | pages = 675–86 | year = 1999 | pmid = 10490106 | doi = 10.1016/S0092-8674(00)80054-9 }}
*{{cite journal | author=Polshakov VI, Williams MA, Gargaro AR, ''et al.'' |title=High-resolution solution structure of human pNR-2/pS2: a single trefoil motif protein. |journal=J. Mol. Biol. |volume=267 |issue= 2 |pages= 418-32 |year= 1997 |pmid= 9096235 |doi= 10.1006/jmbi.1997.0896 }}
*{{cite journal |vauthors=Newton JL, Allen A, Westley BR, May FE | title = The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach. | journal = Gut | volume = 46 | issue = 3 | pages = 312–20 | year = 2000 | pmid = 10673290 | pmc = 1727855 | doi = 10.1136/gut.46.3.312 }}
*{{cite journal | author=Chadwick MP, Westley BR, May FE |title=Homodimerization and hetero-oligomerization of the single-domain trefoil protein pNR-2/pS2 through cysteine 58. |journal=Biochem. J. |volume=327 ( Pt 1) |issue= |pages= 117-23 |year= 1997 |pmid= 9355742 |doi= }}
*{{cite journal | author=Chen H, Lin RJ, Xie W, ''et al.'' |title=Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. |journal=Cell |volume=98 |issue= 5 |pages= 675-86 |year= 1999 |pmid= 10490106 |doi= }}
*{{cite journal  | author=Newton JL, Allen A, Westley BR, May FE |title=The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach. |journal=Gut |volume=46 |issue= 3 |pages= 312-20 |year= 2000 |pmid= 10673290 |doi=  }}
*{{cite journal  | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=7031}}


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{{gene-21-stub}}

Revision as of 05:26, 17 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Trefoil factor 1 is a protein that in humans is encoded by the TFF1 gene[1][2] (also called pS2 gene[3]).

Function

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.[2]

In gastric carcinoma

TFF1 expression is frequently lost in gastric carcinoma, probably through mechanism of DNA methylation, and it is therefore considered as a tumor suppressor gene.[4]

References

  1. ↑ Gött P, Beck S, Machado JC, Carneiro F, Schmitt H, Blin N (May 1997). "Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression". Eur J Hum Genet. 4 (6): 308–15. PMID 9043862.
  2. ↑ 2.0 2.1 "Entrez Gene: TFF1 trefoil factor 1".
  3. ↑ Chatagnon A, Ballestar E, Esteller M, Dante R (2010). "A Role for Methyl-CpG Binding Domain Protein 2 in the Modulation of the Estrogen Response of pS2/TFF1 Gene". PLoS ONE. 5 (3): e9665. doi:10.1371/journal.pone.0009665. PMC 2837351. PMID 20300195.
  4. ↑ Feng G, Zhang Y, Yuan H, Bai R, Zheng J, Zhang J, Song M (Jan 2014). "DNA methylation of trefoil factor 1 (TFF1) is associated with the tumorigenesis of gastric carcinoma". J Mol Med Rep. 9 (1): 109–117. doi:10.3892/mmr.2013.1772. PMID 24190027.

Further reading


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