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{{Infobox_gene}}
{{PBB_Controls
'''Glycoprotein VI (platelet)''' also known as '''GPVI''' is a [[glycoprotein]] receptor for [[collagen]] which is expressed in [[platelets]].  In humans, glycoprotein VI is encoded by the ''GPVI'' [[gene]].<ref name="pmid11027634">{{cite journal | vauthors = Ezumi Y, Uchiyama T, Takayama H | title = Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI | journal = Biochemical and Biophysical Research Communications | volume = 277 | issue = 1 | pages = 27–36 | date = Oct 2000 | pmid = 11027634 | doi = 10.1006/bbrc.2000.3624 }}</ref>
| update_page = yes
GPVI was first cloned in 2000 by several groups including that of [[:fr:Martine Jandrot-Perrus|Martine Jandrot-Perrus]] from INSERM.
| require_manual_inspection = no
== Function ==
| update_protein_box = yes
Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the [[Endothelium|endothelial]] lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most [[thrombogenicity|thrombogenic]] macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of [[atherosclerotic plaque]]s is a major stimulus of thrombus formation associated with myocardial infarction or stroke.<ref>{{cite web | title = Entrez Gene: GP6 glycoprotein VI (platelet)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51206| accessdate = }}</ref><ref name="pmid10961879">{{cite journal | vauthors = Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W, Villeval JL | title = Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily | journal = Blood | volume = 96 | issue = 5 | pages = 1798–807 | date = Sep 2000 | pmid = 10961879 | doi = | url = http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=10961879 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Complete or partial deficiency of GPVI in humans is a rare condition presenting as a mild bleeding disorder.
{{GNF_Protein_box
| image = PBB_Protein_GP6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2gi7.
| PDB = {{PDB2|2gi7}}
| Name = Glycoprotein VI (platelet)
| HGNCid = 14388
| Symbol = GP6
| AltSymbols =; GPIV; GPVI; MGC138168
| OMIM = 605546
| ECnumber = 
| Homologene = 9488
| MGIid = 1889810
| GeneAtlas_image1 = PBB_GE_GP6_220336_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005518 |text = collagen binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007167 |text = enzyme linked receptor protein signaling pathway}} {{GNF_GO|id=GO:0030168 |text = platelet activation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51206
    | Hs_Ensembl = ENSG00000088053
    | Hs_RefseqProtein = NP_057447
    | Hs_RefseqmRNA = NM_016363
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 60216885
    | Hs_GenLoc_end = 60241444
    | Hs_Uniprot = Q9HCN6
    | Mm_EntrezGene = 243816
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_145298
    | Mm_RefseqProtein = XP_145298
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''GPVI''' is a [[gene]] which codes [[glycoprotein]] VI, a glycoprotein receptor for [[collagen]] found on [[platelets]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text = Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: GP6 glycoprotein VI (platelet)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51206| accessdate = }}</ref>
}}


==References==
GPVI has been shown to [[Protein-protein interaction|interact]] with [[LYN]].<ref name=pmid11943772>{{cite journal | vauthors = Suzuki-Inoue K, Tulasne D, Shen Y, Bori-Sanz T, Inoue O, Jung SM, Moroi M, Andrews RK, Berndt MC, Watson SP | title = Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling | journal = The Journal of Biological Chemistry | volume = 277 | issue = 24 | pages = 21561–6 | date = Jun 2002 | pmid = 11943772 | doi = 10.1074/jbc.M201012200 }}</ref>
{{reflist|2}}
 
==Further reading==
== See also ==
* [[collagen receptor]]
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nieswandt B, Watson SP | title = Platelet-collagen interaction: is GPVI the central receptor? | journal = Blood | volume = 102 | issue = 2 | pages = 449–61  | date = Jul 2003 | pmid = 12649139 | doi = 10.1182/blood-2002-12-3882 }}
| citations =
* {{cite journal | vauthors = Watson SP, Auger JM, McCarty OJ, Pearce AC | title = GPVI and integrin alphaIIb beta3 signaling in platelets | journal = Journal of Thrombosis and Haemostasis : JTH | volume = 3 | issue = 8 | pages = 1752–62  | date = Aug 2005 | pmid = 16102042 | doi = 10.1111/j.1538-7836.2005.01429.x }}
*{{cite journal | author=Nieswandt B, Watson SP |title=Platelet-collagen interaction: is GPVI the central receptor? |journal=Blood |volume=102 |issue= 2 |pages= 449-61 |year= 2003 |pmid= 12649139 |doi= 10.1182/blood-2002-12-3882 }}
* {{cite journal | vauthors = Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS | title = Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 17 | pages = 7844–8  | date = Sep 1991 | pmid = 1715582 | pmc = 52400 | doi = 10.1073/pnas.88.17.7844 }}
*{{cite journal | author=Watson SP, Auger JM, McCarty OJ, Pearce AC |title=GPVI and integrin alphaIIb beta3 signaling in platelets. |journal=J. Thromb. Haemost. |volume=3 |issue= 8 |pages= 1752-62 |year= 2005 |pmid= 16102042 |doi= 10.1111/j.1538-7836.2005.01429.x }}
* {{cite journal | vauthors = Moroi M, Jung SM, Okuma M, Shinmyozu K | title = A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion | journal = The Journal of Clinical Investigation | volume = 84 | issue = 5 | pages = 1440–5  | date = Nov 1989 | pmid = 2808700 | pmc = 304007 | doi = 10.1172/JCI114318 }}
*{{cite journal | author=Huang MM, Bolen JB, Barnwell JW, ''et al.'' |title=Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 17 |pages= 7844-8 |year= 1991 |pmid= 1715582 |doi= }}
* {{cite journal | vauthors = Polgár J, Clemetson JM, Kehrel BE, Wiedemann M, Magnenat EM, Wells TN, Clemetson KJ | title = Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor | journal = The Journal of Biological Chemistry | volume = 272 | issue = 21 | pages = 13576–83  | date = May 1997 | pmid = 9153205 | doi = 10.1074/jbc.272.21.13576 }}
*{{cite journal | author=Moroi M, Jung SM, Okuma M, Shinmyozu K |title=A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion. |journal=J. Clin. Invest. |volume=84 |issue= 5 |pages= 1440-5 |year= 1989 |pmid= 2808700 |doi= }}
* {{cite journal | vauthors = Gibbins JM, Okuma M, Farndale R, Barnes M, Watson SP | title = Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain | journal = FEBS Letters | volume = 413 | issue = 2 | pages = 255–9  | date = Aug 1997 | pmid = 9280292 | doi = 10.1016/S0014-5793(97)00926-5 }}
*{{cite journal | author=Polgár J, Clemetson JM, Kehrel BE, ''et al.'' |title=Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. |journal=J. Biol. Chem. |volume=272 |issue= 21 |pages= 13576-83 |year= 1997 |pmid= 9153205 |doi= }}
* {{cite journal | vauthors = Tsuji M, Ezumi Y, Arai M, Takayama H | title = A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets | journal = The Journal of Biological Chemistry | volume = 272 | issue = 38 | pages = 23528–31  | date = Sep 1997 | pmid = 9295288 | doi = 10.1074/jbc.272.38.23528 }}
*{{cite journal | author=Gibbins JM, Okuma M, Farndale R, ''et al.'' |title=Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain. |journal=FEBS Lett. |volume=413 |issue= 2 |pages= 255-9 |year= 1997 |pmid= 9280292 |doi= }}
* {{cite journal | vauthors = Clemetson JM, Polgar J, Magnenat E, Wells TN, Clemetson KJ | title = The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors | journal = The Journal of Biological Chemistry | volume = 274 | issue = 41 | pages = 29019–24  | date = Oct 1999 | pmid = 10506151 | doi = 10.1074/jbc.274.41.29019 }}
*{{cite journal | author=Tsuji M, Ezumi Y, Arai M, Takayama H |title=A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets. |journal=J. Biol. Chem. |volume=272 |issue= 38 |pages= 23528-31 |year= 1997 |pmid= 9295288 |doi= }}
* {{cite journal | vauthors = Miura Y, Ohnuma M, Jung SM, Moroi M | title = Cloning and expression of the platelet-specific collagen receptor glycoprotein VI | journal = [[Thrombosis Research]] | volume = 98 | issue = 4 | pages = 301–9  | date = May 2000 | pmid = 10822077 | doi = 10.1016/S0049-3848(00)00182-1 }}
*{{cite journal | author=Clemetson JM, Polgar J, Magnenat E, ''et al.'' |title=The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors. |journal=J. Biol. Chem. |volume=274 |issue= 41 |pages= 29019-24 |year= 1999 |pmid= 10506151 |doi= }}
* {{cite journal | vauthors = Nieswandt B, Bergmeier W, Schulte V, Rackebrandt K, Gessner JE, Zirngibl H | title = Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain | journal = The Journal of Biological Chemistry | volume = 275 | issue = 31 | pages = 23998–4002  | date = Aug 2000 | pmid = 10825177 | doi = 10.1074/jbc.M003803200 }}
*{{cite journal | author=Miura Y, Ohnuma M, Jung SM, Moroi M |title=Cloning and expression of the platelet-specific collagen receptor glycoprotein VI. |journal=Thromb. Res. |volume=98 |issue= 4 |pages= 301-9 |year= 2000 |pmid= 10822077 |doi= }}
* {{cite journal |author-link1=:fr:Martine_Jandrot-Perrus |vauthors=Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W, Villeval JL | title = Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily | journal = Blood | volume = 96 | issue = 5 | pages = 1798–807  | date = Sep 2000 | pmid = 10961879 | doi =  }}
*{{cite journal | author=Nieswandt B, Bergmeier W, Schulte V, ''et al.'' |title=Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23998-4002 |year= 2000 |pmid= 10825177 |doi= 10.1074/jbc.M003803200 }}
* {{cite journal | vauthors = Ezumi Y, Uchiyama T, Takayama H | title = Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI | journal = Biochemical and Biophysical Research Communications | volume = 277 | issue = 1 | pages = 27–36  | date = Oct 2000 | pmid = 11027634 | doi = 10.1006/bbrc.2000.3624 }}
*{{cite journal | author=Jandrot-Perrus M, Busfield S, Lagrue AH, ''et al.'' |title=Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. |journal=Blood |volume=96 |issue= 5 |pages= 1798-807 |year= 2000 |pmid= 10961879 |doi=  }}
* {{cite journal | vauthors = Barry FA, Gibbins JM | title = Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI | journal = The Journal of Biological Chemistry | volume = 277 | issue = 15 | pages = 12874–8  | date = Apr 2002 | pmid = 11825911 | doi = 10.1074/jbc.M200482200 }}
*{{cite journal | author=Ezumi Y, Uchiyama T, Takayama H |title=Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI. |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 1 |pages= 27-36 |year= 2000 |pmid= 11027634 |doi= 10.1006/bbrc.2000.3624 }}
* {{cite journal | vauthors = Suzuki-Inoue K, Tulasne D, Shen Y, Bori-Sanz T, Inoue O, Jung SM, Moroi M, Andrews RK, Berndt MC, Watson SP | title = Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling | journal = The Journal of Biological Chemistry | volume = 277 | issue = 24 | pages = 21561–6  | date = Jun 2002 | pmid = 11943772 | doi = 10.1074/jbc.M201012200 }}
*{{cite journal | author=Barry FA, Gibbins JM |title=Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12874-8 |year= 2002 |pmid= 11825911 |doi= 10.1074/jbc.M200482200 }}
* {{cite journal | vauthors = Quinton TM, Ozdener F, Dangelmaier C, Daniel JL, Kunapuli SP | title = Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP | journal = Blood | volume = 99 | issue = 9 | pages = 3228–34  | date = May 2002 | pmid = 11964287 | doi = 10.1182/blood.V99.9.3228 }}
*{{cite journal | author=Suzuki-Inoue K, Tulasne D, Shen Y, ''et al.'' |title=Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21561-6 |year= 2002 |pmid= 11943772 |doi= 10.1074/jbc.M201012200 }}
* {{cite journal | vauthors = Saving KL, Mankin PE, Gorman MJ | title = Differences in adhesion receptor expression between immature and older platelets and red blood cells of neonates and adults | journal = Journal of Pediatric Hematology/oncology | volume = 24 | issue = 2 | pages = 120–4  | date = Feb 2002 | pmid = 11990697 | doi = 10.1097/00043426-200202000-00012 }}
*{{cite journal | author=Quinton TM, Ozdener F, Dangelmaier C, ''et al.'' |title=Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP. |journal=Blood |volume=99 |issue= 9 |pages= 3228-34 |year= 2002 |pmid= 11964287 |doi= }}
* {{cite journal | vauthors = Andrews RK, Suzuki-Inoue K, Shen Y, Tulasne D, Watson SP, Berndt MC | title = Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI | journal = Blood | volume = 99 | issue = 11 | pages = 4219–21  | date = Jun 2002 | pmid = 12010829 | doi = 10.1182/blood-2001-11-0008 }}
*{{cite journal | author=Saving KL, Mankin PE, Gorman MJ |title=Differences in adhesion receptor expression between immature and older platelets and red blood cells of neonates and adults. |journal=J. Pediatr. Hematol. Oncol. |volume=24 |issue= 2 |pages= 120-4 |year= 2002 |pmid= 11990697 |doi= }}
* {{cite journal | vauthors = Wonerow P, Obergfell A, Wilde JI, Bobe R, Asazuma N, Brdicka T, Leo A, Schraven B, Horejsí V, Shattil SJ, Watson SP | title = Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets | journal = The Biochemical Journal | volume = 364 | issue = Pt 3 | pages = 755–65  | date = Jun 2002 | pmid = 12049640 | pmc = 1222625 | doi = 10.1042/BJ20020128 }}
*{{cite journal | author=Andrews RK, Suzuki-Inoue K, Shen Y, ''et al.'' |title=Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI. |journal=Blood |volume=99 |issue= 11 |pages= 4219-21 |year= 2002 |pmid= 12010829 |doi= 10.1182/blood-2001-11-0008 }}
* {{cite journal | vauthors = Miura Y, Takahashi T, Jung SM, Moroi M | title = Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen | journal = The Journal of Biological Chemistry | volume = 277 | issue = 48 | pages = 46197–204 | date = Nov 2002 | pmid = 12356768 | doi = 10.1074/jbc.M204029200 |doi-access=free}}
*{{cite journal | author=Wonerow P, Obergfell A, Wilde JI, ''et al.'' |title=Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets. |journal=Biochem. J. |volume=364 |issue= Pt 3 |pages= 755-65 |year= 2002 |pmid= 12049640 |doi= 10.1042/BJ20020128 }}
* {{cite journal | vauthors = Holmes ML, Bartle N, Eisbacher M, Chong BH | title = Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 50 | pages = 48333–41 | date = Dec 2002 | pmid = 12359731 | doi = 10.1074/jbc.M206127200 |doi-access=free}}
*{{cite journal | author=Miura Y, Takahashi T, Jung SM, Moroi M |title=Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46197-204 |year= 2003 |pmid= 12356768 |doi= 10.1074/jbc.M204029200 }}
*{{cite journal | author=Holmes ML, Bartle N, Eisbacher M, Chong BH |title=Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 48333-41 |year= 2003 |pmid= 12359731 |doi= 10.1074/jbc.M206127200 }}
}}
{{refend}}
{{refend}}


== External links ==
* {{MeshName|GPVI+protein,+human}}
{{PDB Gallery|geneid=51206}}
{{Coagulation}}


{{biochemistry-stub}}
[[Category:Human genes]]
[[Category:Genes]]
{{WikiDoc Sources}}

Revision as of 15:21, 5 November 2017

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Glycoprotein VI (platelet) also known as GPVI is a glycoprotein receptor for collagen which is expressed in platelets. In humans, glycoprotein VI is encoded by the GPVI gene.[1] GPVI was first cloned in 2000 by several groups including that of Martine Jandrot-Perrus from INSERM.

Function

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.[2][3]

Complete or partial deficiency of GPVI in humans is a rare condition presenting as a mild bleeding disorder.

Interactions

GPVI has been shown to interact with LYN.[4]

See also

References

  1. ↑ Ezumi Y, Uchiyama T, Takayama H (Oct 2000). "Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI". Biochemical and Biophysical Research Communications. 277 (1): 27–36. doi:10.1006/bbrc.2000.3624. PMID 11027634.
  2. ↑ "Entrez Gene: GP6 glycoprotein VI (platelet)".
  3. ↑ Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W, Villeval JL (Sep 2000). "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily". Blood. 96 (5): 1798–807. PMID 10961879.
  4. ↑ Suzuki-Inoue K, Tulasne D, Shen Y, Bori-Sanz T, Inoue O, Jung SM, Moroi M, Andrews RK, Berndt MC, Watson SP (Jun 2002). "Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling". The Journal of Biological Chemistry. 277 (24): 21561–6. doi:10.1074/jbc.M201012200. PMID 11943772.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=GPVI&oldid=1418663"