PIP4K2B: Difference between revisions

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Revision as of 16:11, 18 November 2017

Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene.^[1]^[2]^[3]^[4]

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.^[4]

Interactions

PIP4K2B has been shown to interact with TNFRSF1A.^[1]

References

↑ ^1.0 ^1.1 Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV (Apr 1997). "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase". J Biol Chem. 272 (9): 5861–70. doi:10.1074/jbc.272.9.5861. PMID 9038203.
↑ Luoh SW, Venkatesan N, Tripathi R (Feb 2004). "Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage". Oncogene. 23 (7): 1354–63. doi:10.1038/sj.onc.1207251. PMID 14691457.
↑ Rameh LE, Tolias KF, Duckworth BC, Cantley LC (Nov 1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192–6. doi:10.1038/36621. PMID 9367159.
↑ ^4.0 ^4.1 "Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta".

Niiro H, Clark EA (2003). "Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1". Immunity. 19 (5): 637–40. doi:10.1016/S1074-7613(03)00303-0. PMID 14614850.
Carpenter CL (2004). "Btk-dependent regulation of phosphoinositide synthesis". Biochem. Soc. Trans. 32 (Pt 2): 326–9. doi:10.1042/BST0320326. PMID 15046600.
Rao VD, Misra S, Boronenkov IV, et al. (1998). "Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation". Cell. 94 (6): 829–39. doi:10.1016/S0092-8674(00)81741-9. PMID 9753329.
Boronenkov IV, Loijens JC, Umeda M, Anderson RA (1999). "Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors". Mol. Biol. Cell. 9 (12): 3547–60. doi:10.1091/mbc.9.12.3547. PMC 25675. PMID 9843587.
Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Richardson JP, Wang M, Clarke JH, et al. (2007). "Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation". Cell. Signal. 19 (6): 1309–14. doi:10.1016/j.cellsig.2007.01.010. PMC 1868964. PMID 17303380.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[pmid9038203-1] 1.0 ^1.1 Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV (Apr 1997). "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase". J Biol Chem. 272 (9): 5861–70. doi:10.1074/jbc.272.9.5861. PMID 9038203.

[pmid14691457-2] Luoh SW, Venkatesan N, Tripathi R (Feb 2004). "Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage". Oncogene. 23 (7): 1354–63. doi:10.1038/sj.onc.1207251. PMID 14691457.

[pmid9367159-3] Rameh LE, Tolias KF, Duckworth BC, Cantley LC (Nov 1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192–6. doi:10.1038/36621. PMID 9367159.

[entrez-4] 4.0 ^4.1 "Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta".

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Phosphatidylinositol-5-phosphate 4-kinase type-2 beta''' is an [[enzyme]] that in humans is encoded by the ''PIP4K2B'' [[gene]].<ref name="pmid9038203">{{cite journal | vauthors = Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV | title = A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase | journal = J Biol Chem | volume = 272 | issue = 9 | pages = 5861–70 |date=Apr 1997 | pmid = 9038203 | pmc =  | doi =10.1074/jbc.272.9.5861  }}</ref><ref name="pmid14691457">{{cite journal | vauthors = Luoh SW, Venkatesan N, Tripathi R | title = Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage | journal = Oncogene | volume = 23 | issue = 7 | pages = 1354–63 |date=Feb 2004 | pmid = 14691457 | pmc =  | doi = 10.1038/sj.onc.1207251 }}</ref><ref name="pmid9367159">{{cite journal | vauthors = Rameh LE, Tolias KF, Duckworth BC, Cantley LC | title = A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate | journal = Nature | volume = 390 | issue = 6656 | pages = 192–6 |date=Nov 1997 | pmid = 9367159 | pmc =  | doi = 10.1038/36621 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8396| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_PIP5K2B_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bo1.
- | PDB = {{PDB2|1bo1}}
- | Name = Phosphatidylinositol-4-phosphate 5-kinase, type II, beta
- | HGNCid = 8998
- | Symbol = PIP5K2B
- | AltSymbols =; PIP5KIIB; Pip4k2B
- | OMIM = 603261
- | ECnumber =
- | Homologene = 2634
- | MGIid = 1934234
-  | GeneAtlas_image1 = PBB_GE_PIP5K2B_201080_at_tn.png
- | GeneAtlas_image2 = PBB_GE_PIP5K2B_201081_s_at_tn.png
-  | Function = {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016308 |text = 1-phosphatidylinositol-4-phosphate 5-kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0046488 |text = phosphatidylinositol metabolic process}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8396
-    | Hs_Ensembl = ENSG00000141720
-    | Hs_RefseqProtein = NP_619632
-    | Hs_RefseqmRNA = NM_138687
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 17
-    | Hs_GenLoc_start = 34177324
-    | Hs_GenLoc_end = 34209684
-    | Hs_Uniprot = P78356
-    | Mm_EntrezGene = 108083
-    | Mm_Ensembl = ENSMUSG00000018547
-    | Mm_RefseqmRNA = XM_991560
-    | Mm_RefseqProtein = XP_996654
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 11
-    | Mm_GenLoc_start = 97531247
-    | Mm_GenLoc_end = 97560794
-    | Mm_Uniprot = Q3UJ95
-  }}
-}}
-'''Phosphatidylinositol-4-phosphate 5-kinase, type II, beta''', also known as '''PIP5K2B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8396| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.<ref name="entrez">{{cite web | title = Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8396| accessdate = }}</ref>
+| summary_text = The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.<ref name="entrez">{{cite web | title = Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8396| accessdate = }}</ref>
 }}
+==Interactions==
+PIP4K2B has been shown to [[Protein-protein interaction|interact]] with [[TNFRSF1A]].<ref name=pmid9038203 />
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Niiro H, Clark EA |title=Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1. |journal=Immunity |volume=19 |issue= 5 |pages= 637-40 |year= 2003 |pmid= 14614850 |doi=  }}
+*{{cite journal  | vauthors=Niiro H, Clark EA |title=Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1. |journal=Immunity |volume=19 |issue= 5 |pages= 637–40 |year= 2003 |pmid= 14614850 |doi=10.1016/S1074-7613(03)00303-0  }}
-*{{cite journal  | author=Carpenter CL |title=Btk-dependent regulation of phosphoinositide synthesis. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 2 |pages= 326-9 |year= 2004 |pmid= 15046600 |doi= 10.1042/ }}
+*{{cite journal  | author=Carpenter CL |title=Btk-dependent regulation of phosphoinositide synthesis. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 2 |pages= 326–9 |year= 2004 |pmid= 15046600 |doi=10.1042/BST0320326  }}
-*{{cite journal  | author=Castellino AM, Parker GJ, Boronenkov IV, ''et al.'' |title=A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 5861-70 |year= 1997 |pmid= 9038203 |doi=  }}
+*{{cite journal   |vauthors=Rao VD, Misra S, Boronenkov IV, etal |title=Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. |journal=Cell |volume=94 |issue= 6 |pages= 829–39 |year= 1998 |pmid= 9753329 |doi=10.1016/S0092-8674(00)81741-9  }}
-*{{cite journal  | author=Rameh LE, Tolias KF, Duckworth BC, Cantley LC |title=A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. |journal=Nature |volume=390 |issue= 6656 |pages= 192-6 |year= 1997 |pmid= 9367159 |doi= 10.1038/36621 }}
+*{{cite journal  | vauthors=Boronenkov IV, Loijens JC, Umeda M, Anderson RA |title=Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. |journal=Mol. Biol. Cell |volume=9 |issue= 12 |pages= 3547–60 |year= 1999 |pmid= 9843587 |doi=  10.1091/mbc.9.12.3547| pmc=25675  }}
-*{{cite journal  | author=Rao VD, Misra S, Boronenkov IV, ''et al.'' |title=Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. |journal=Cell |volume=94 |issue= 6 |pages= 829-39 |year= 1998 |pmid= 9753329 |doi=  }}
+*{{cite journal   |vauthors=Kutsenko AS, Gizatullin RZ, Al-Amin AN, etal |title=NotI flanking sequences: a tool for gene discovery and verification of the human genome. |journal=Nucleic Acids Res. |volume=30 |issue= 14 |pages= 3163–70 |year= 2002 |pmid= 12136098 |doi=10.1093/nar/gkf428  | pmc=135748  }}
-*{{cite journal  | author=Boronenkov IV, Loijens JC, Umeda M, Anderson RA |title=Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. |journal=Mol. Biol. Cell |volume=9 |issue= 12 |pages= 3547-60 |year= 1999 |pmid= 9843587 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Kutsenko AS, Gizatullin RZ, Al-Amin AN, ''et al.'' |title=NotI flanking sequences: a tool for gene discovery and verification of the human genome. |journal=Nucleic Acids Res. |volume=30 |issue= 14 |pages= 3163-70 |year= 2002 |pmid= 12136098 |doi=  }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Luoh SW, Venkatesan N, Tripathi R |title=Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage. |journal=Oncogene |volume=23 |issue= 7 |pages= 1354-63 |year= 2004 |pmid= 14691457 |doi= 10.1038/sj.onc.1207251 }}
+*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Richardson JP, Wang M, Clarke JH, etal |title=Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation. |journal=Cell. Signal. |volume=19 |issue= 6 |pages= 1309–14 |year= 2007 |pmid= 17303380 |doi= 10.1016/j.cellsig.2007.01.010  | pmc=1868964 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
-*{{cite journal  | author=Richardson JP, Wang M, Clarke JH, ''et al.'' |title=Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation. |journal=Cell. Signal. |volume=19 |issue= 6 |pages= 1309-14 |year= 2007 |pmid= 17303380 |doi= 10.1016/j.cellsig.2007.01.010 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=8396}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
-{{protein-stub}}
+{{gene-17-stub}}
-{{WikiDoc Sources}}

PIP4K2B: Difference between revisions

Revision as of 16:11, 18 November 2017

Interactions

References

Further reading

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