SF3B3: Difference between revisions
Jump to navigation
Jump to search
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +)) |
m (Bot: HTTP→HTTPS) |
||
| Line 1: | Line 1: | ||
{{Infobox_gene}} | |||
{{ | '''Splicing factor 3B subunit 3''' is a [[protein]] that in humans is encoded by the ''SF3B3'' [[gene]].<ref name="pmid10490618">{{cite journal |author1=Das BK |author2=Xia L |author3=Palandjian L |author4=Gozani O |author5=Chyung Y |author6=Reed R | title = Characterization of a Protein Complex Containing Spliceosomal Proteins SAPs 49, 130, 145, and 155 | journal = Mol Cell Biol | volume = 19 | issue = 10 | pages = 6796–802 |date=February 2000 | pmid = 10490618 | pmc = 84676 | doi = 10.1128/mcb.19.10.6796}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SF3B3 splicing factor 3b, subunit 3, 130kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23450| accessdate = }}</ref> | ||
}} | |||
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | <!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | ||
{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.<ref name="entrez" | | summary_text = This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.<ref name="entrez" /> | ||
}} | }} | ||
==Interactions== | |||
SF3B3 has been shown to [[Protein-protein interaction|interact]] with [[SF3B1]],<ref name=pmid10490618 /><ref name=pmid12234937>{{cite journal |last=Will |first=Cindy L |authorlink= |author2=Urlaub Henning |author3=Achsel Tilmann |author4=Gentzel Marc |author5=Wilm Matthias |author6=Lührmann Reinhard |date=September 2002 |title=Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein |journal=EMBO J. |volume=21 |issue=18 |pages=4978–88 |publisher= |location = England| issn = 0261-4189| pmid = 12234937 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/emboj/cdf480 |pmc=126279 }}</ref> [[Transcription initiation protein SPT3 homolog]]<ref name=pmid11564863>{{cite journal |last=Martinez |first=E |authorlink= |author2=Palhan V B |author3=Tjernberg A |author4=Lymar E S |author5=Gamper A M |author6=Kundu T K |author7=Chait B T |author8=Roeder R G |date=October 2001 |title=Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo |journal=Mol. Cell. Biol. |volume=21 |issue=20 |pages=6782–95 |publisher= |location = United States| issn = 0270-7306| pmid = 11564863 |doi = 10.1128/MCB.21.20.6782-6795.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=99856 }}</ref> and [[TAF9]].<ref name=pmid11564863/> | |||
==References== | ==References== | ||
{{ | {{Reflist}} | ||
==Further reading== | ==Further reading== | ||
{{ | {{Refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | *{{cite journal |vauthors=Nomura N, Miyajima N, Sazuka T, etal |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=10.1093/dnares/1.1.27 }} | ||
*{{cite journal | *{{cite journal |vauthors=Nomura N, Miyajima N, Sazuka T, etal |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement) |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=10.1093/dnares/1.1.47 }} | ||
*{{cite journal | | *{{cite journal |author1=Bonaldo MF |author2=Lennon G |author3=Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }} | ||
*{{cite journal | *{{cite journal |vauthors=Mintz PJ, Patterson SD, Neuwald AF, etal |title=Purification and biochemical characterization of interchromatin granule clusters |journal=EMBO J. |volume=18 |issue= 15 |pages= 4308–20 |year= 1999 |pmid= 10428969 |doi= 10.1093/emboj/18.15.4308 | pmc=1171507 }} | ||
*{{cite journal | *{{cite journal |vauthors=Brand M, Moggs JG, Oulad-Abdelghani M, etal |title=UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation |journal=EMBO J. |volume=20 |issue= 12 |pages= 3187–96 |year= 2001 |pmid= 11406595 |doi= 10.1093/emboj/20.12.3187 | pmc=150203 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gangloff YG, Pointud JC, Thuault S, etal |title=The TFIID Components Human TAFII140 and Drosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 5109–21 |year= 2001 |pmid= 11438666 |doi= 10.1128/MCB.21.15.5109-5121.2001 | pmc=87236 }} | ||
*{{cite journal | *{{cite journal |vauthors=Will CL, Schneider C, MacMillan AM, etal |title=A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site |journal=EMBO J. |volume=20 |issue= 16 |pages= 4536–46 |year= 2001 |pmid= 11500380 |doi= 10.1093/emboj/20.16.4536 | pmc=125580 }} | ||
*{{cite journal | *{{cite journal |vauthors=Martinez E, Palhan VB, Tjernberg A, etal |title=Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6782–95 |year= 2001 |pmid= 11564863 |doi= 10.1128/MCB.21.20.6782-6795.2001 | pmc=99856 }} | ||
*{{cite journal | *{{cite journal |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088 | pmc=1370266 }} | ||
*{{cite journal | *{{cite journal |vauthors=Scott MP, Zappacosta F, Kim EY, etal |title=Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1 |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28238–46 |year= 2002 |pmid= 12029088 |doi= 10.1074/jbc.M202783200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Will CL, Urlaub H, Achsel T, etal |title=Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein |journal=EMBO J. |volume=21 |issue= 18 |pages= 4978–88 |year= 2002 |pmid= 12234937 |doi=10.1093/emboj/cdf480 | pmc=126279 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | | *{{cite journal |author1=Cavusoglu N |author2=Brand M |author3=Tora L |author4=Van Dorsselaer A |title=Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis |journal=Proteomics |volume=3 |issue= 2 |pages= 217–23 |year= 2003 |pmid= 12601814 |doi= 10.1002/pmic.200390030 }} | ||
*{{cite journal | *{{cite journal |vauthors=Li J, Hawkins IC, Harvey CD, etal |title=Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437–47 |year= 2003 |pmid= 14559993 |doi=10.1128/MCB.23.21.7437-7447.2003 | pmc=207616 }} | ||
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | |||
*{{cite journal | *{{cite journal |vauthors=Will CL, Schneider C, Hossbach M, etal |title=The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome |journal=RNA |volume=10 |issue= 6 |pages= 929–41 |year= 2004 |pmid= 15146077 |doi=10.1261/rna.7320604 | pmc=1370585 }} | ||
*{{cite journal | *{{cite journal |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }} | ||
}} | }} | ||
{{ | {{Refend}} | ||
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. --> | |||
{{PBB_Controls | |||
| update_page = yes | |||
| require_manual_inspection = no | |||
| update_protein_box = yes | |||
| update_summary = yes | |||
| update_citations = yes | |||
}} | |||
{{ | {{Gene-16-stub}} | ||
Revision as of 06:12, 11 September 2017
| VALUE_ERROR (nil) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | |||||||
| External IDs | GeneCards: [1] | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez |
|
| |||||
| Ensembl |
|
| |||||
| UniProt |
|
| |||||
| RefSeq (mRNA) |
|
| |||||
| RefSeq (protein) |
|
| |||||
| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
| |||||||
Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.[1][2]
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.[2]
Interactions
SF3B3 has been shown to interact with SF3B1,[1][3] Transcription initiation protein SPT3 homolog[4] and TAF9.[4]
References
- ↑ 1.0 1.1 Das BK; Xia L; Palandjian L; Gozani O; Chyung Y; Reed R (February 2000). "Characterization of a Protein Complex Containing Spliceosomal Proteins SAPs 49, 130, 145, and 155". Mol Cell Biol. 19 (10): 6796–802. doi:10.1128/mcb.19.10.6796. PMC 84676. PMID 10490618.
- ↑ 2.0 2.1 "Entrez Gene: SF3B3 splicing factor 3b, subunit 3, 130kDa".
- ↑ Will, Cindy L; Urlaub Henning; Achsel Tilmann; Gentzel Marc; Wilm Matthias; Lührmann Reinhard (September 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. England. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. ISSN 0261-4189. PMC 126279. PMID 12234937.
- ↑ 4.0 4.1 Martinez, E; Palhan V B; Tjernberg A; Lymar E S; Gamper A M; Kundu T K; Chait B T; Roeder R G (October 2001). "Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo". Mol. Cell. Biol. United States. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. ISSN 0270-7306. PMC 99856. PMID 11564863.
Further reading
- Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
- Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
- Bonaldo MF; Lennon G; Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Mintz PJ, Patterson SD, Neuwald AF, et al. (1999). "Purification and biochemical characterization of interchromatin granule clusters". EMBO J. 18 (15): 4308–20. doi:10.1093/emboj/18.15.4308. PMC 1171507. PMID 10428969.
- Brand M, Moggs JG, Oulad-Abdelghani M, et al. (2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". EMBO J. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595.
- Gangloff YG, Pointud JC, Thuault S, et al. (2001). "The TFIID Components Human TAFII140 and Drosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger". Mol. Cell. Biol. 21 (15): 5109–21. doi:10.1128/MCB.21.15.5109-5121.2001. PMC 87236. PMID 11438666.
- Will CL, Schneider C, MacMillan AM, et al. (2001). "A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site". EMBO J. 20 (16): 4536–46. doi:10.1093/emboj/20.16.4536. PMC 125580. PMID 11500380.
- Martinez E, Palhan VB, Tjernberg A, et al. (2001). "Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.
- Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
- Scott MP, Zappacosta F, Kim EY, et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". J. Biol. Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.
- Will CL, Urlaub H, Achsel T, et al. (2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cavusoglu N; Brand M; Tora L; Van Dorsselaer A (2003). "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis". Proteomics. 3 (2): 217–23. doi:10.1002/pmic.200390030. PMID 12601814.
- Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
- Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
 | This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it. |