SLC7A8: Difference between revisions

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Latest revision as of 06:36, 11 September 2017

Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene.^[1]^[2]^[3]

References

↑ Borsani G, Bassi MT, Sperandeo MP, De Grandi A, Buoninconti A, Riboni M, Manzoni M, Incerti B, Pepe A, Andria G, Ballabio A, Sebastio G (Mar 1999). "SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance". Nat Genet. 21 (3): 297–301. doi:10.1038/6815. PMID 10080183.
↑ Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M (Aug 1999). "Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids". J Biol Chem. 274 (28): 19738–44. doi:10.1074/jbc.274.28.19738. PMID 10391915.
↑ "Entrez Gene: SLC7A8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Rossier G, Meier C, Bauch C, et al. (2000). "LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine". J. Biol. Chem. 274 (49): 34948–54. doi:10.1074/jbc.274.49.34948. PMID 10574970.
Bassi MT, Sperandeo MP, Incerti B, et al. (2000). "SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family". Genomics. 62 (2): 297–303. doi:10.1006/geno.1999.5978. PMID 10610726.
Bröer A, Friedrich B, Wagner CA, et al. (2001). "Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains". Biochem. J. 355 (Pt 3): 725–31. PMC 1221788. PMID 11311135.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu X, Charrier L, Gewirtz A, et al. (2003). "CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia". J. Biol. Chem. 278 (26): 23672–7. doi:10.1074/jbc.M302777200. PMID 12716892.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Li S, Whorton AR (2005). "Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols". J. Biol. Chem. 280 (20): 20102–10. doi:10.1074/jbc.M413164200. PMID 15769744.
Kühne A, Kaiser R, Schirmer M, et al. (2007). "Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan". Pharmacogenet. Genomics. 17 (7): 505–17. doi:10.1097/FPC.0b013e3280ea77cd. PMID 17558306.

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[pmid10080183-1] Borsani G, Bassi MT, Sperandeo MP, De Grandi A, Buoninconti A, Riboni M, Manzoni M, Incerti B, Pepe A, Andria G, Ballabio A, Sebastio G (Mar 1999). "SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance". Nat Genet. 21 (3): 297–301. doi:10.1038/6815. PMID 10080183.

[pmid10391915-2] Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M (Aug 1999). "Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids". J Biol Chem. 274 (28): 19738–44. doi:10.1074/jbc.274.28.19738. PMID 10391915.

[entrez-3] "Entrez Gene: SLC7A8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Large neutral amino acids transporter small subunit 2''' is a [[protein]] that in humans is encoded by the ''SLC7A8'' [[gene]].<ref name="pmid10080183">{{cite journal | vauthors = Borsani G, Bassi MT, Sperandeo MP, De Grandi A, Buoninconti A, Riboni M, Manzoni M, Incerti B, Pepe A, Andria G, Ballabio A, Sebastio G | title = SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance | journal = Nat Genet | volume = 21 | issue = 3 | pages = 297–301 |date=Mar 1999 | pmid = 10080183 | pmc =  | doi = 10.1038/6815 }}</ref><ref name="pmid10391915">{{cite journal | vauthors = Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M | title = Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids | journal = J Biol Chem | volume = 274 | issue = 28 | pages = 19738–44 |date=Aug 1999 | pmid = 10391915 | pmc =  | doi =10.1074/jbc.274.28.19738  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC7A8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23428| accessdate = }}</ref>
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
- | HGNCid = 11066
- | Symbol = SLC7A8
- | AltSymbols =; LAT2; LPI-PC1
- | OMIM = 604235
- | ECnumber =
- | Homologene = 8166
- | MGIid = 1355323
- | GeneAtlas_image1 = PBB_GE_SLC7A8_216092_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_SLC7A8_202752_x_at_tn.png
-  | GeneAtlas_image3 = PBB_GE_SLC7A8_217248_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0005279 |text = amine transmembrane transporter activity}} {{GNF_GO|id=GO:0015175 |text = neutral amino acid transmembrane transporter activity}} {{GNF_GO|id=GO:0015179 |text = L-amino acid transmembrane transporter activity}} {{GNF_GO|id=GO:0015359 |text = amino acid transmembrane transporter activity}} {{GNF_GO|id=GO:0042605 |text = peptide antigen binding}}
- | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
-  | Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006520 |text = amino acid metabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006865 |text = amino acid transport}} {{GNF_GO|id=GO:0015804 |text = neutral amino acid transport}} {{GNF_GO|id=GO:0015807 |text = L-amino acid transport}}
-  | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 23428
-    | Hs_Ensembl = ENSG00000092068
-    | Hs_RefseqProtein = NP_036376
-    | Hs_RefseqmRNA = NM_012244
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 14
-    | Hs_GenLoc_start = 22664346
-    | Hs_GenLoc_end = 22722689
-    | Hs_Uniprot = Q9UHI5
-    | Mm_EntrezGene = 50934
-    | Mm_Ensembl = ENSMUSG00000022180
-    | Mm_RefseqmRNA = NM_016972
-    | Mm_RefseqProtein = NP_058668
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 14
-    | Mm_GenLoc_start = 53676418
-    | Mm_GenLoc_end = 53736091
-    | Mm_Uniprot = Q9QXW9
-  }}
-}}
-'''Solute carrier family 7 (cationic amino acid transporter, y+ system), member 8''', also known as '''SLC7A8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC7A8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23428| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 57: / Line 9: @@
 ==See also==
+* [[Heterodimeric amino acid transporter]]
 * [[Solute carrier family]]
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 66: / Line 19: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
-*{{cite journal  | author=Borsani G, Bassi MT, Sperandeo MP, ''et al.'' |title=SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance. |journal=Nat. Genet. |volume=21 |issue= 3 |pages= 297-301 |year= 1999 |pmid= 10080183 |doi= 10.1038/6815 }}
+*{{cite journal   |vauthors=Rossier G, Meier C, Bauch C, etal |title=LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 34948–54 |year= 2000 |pmid= 10574970 |doi=10.1074/jbc.274.49.34948  }}
-*{{cite journal  | author=Pineda M, Fernández E, Torrents D, ''et al.'' |title=Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. |journal=J. Biol. Chem. |volume=274 |issue= 28 |pages= 19738-44 |year= 1999 |pmid= 10391915 |doi=  }}
+*{{cite journal   |vauthors=Bassi MT, Sperandeo MP, Incerti B, etal |title=SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family |journal=Genomics |volume=62 |issue= 2 |pages= 297–303 |year= 2000 |pmid= 10610726 |doi= 10.1006/geno.1999.5978 }}
-*{{cite journal  | author=Rossier G, Meier C, Bauch C, ''et al.'' |title=LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 34948-54 |year= 2000 |pmid= 10574970 |doi=  }}
+*{{cite journal   |vauthors=Bröer A, Friedrich B, Wagner CA, etal |title=Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains |journal=Biochem. J. |volume=355 |issue= Pt 3 |pages= 725–31 |year= 2001 |pmid= 11311135 |doi=  | pmc=1221788  }}
-*{{cite journal  | author=Bassi MT, Sperandeo MP, Incerti B, ''et al.'' |title=SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family. |journal=Genomics |volume=62 |issue= 2 |pages= 297-303 |year= 2000 |pmid= 10610726 |doi= 10.1006/geno.1999.5978 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Bröer A, Friedrich B, Wagner CA, ''et al.'' |title=Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains. |journal=Biochem. J. |volume=355 |issue= Pt 3 |pages= 725-31 |year= 2001 |pmid= 11311135 |doi=  }}
+*{{cite journal   |vauthors=Liu X, Charrier L, Gewirtz A, etal |title=CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 23672–7 |year= 2003 |pmid= 12716892 |doi= 10.1074/jbc.M302777200 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Liu X, Charrier L, Gewirtz A, ''et al.'' |title=CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia. |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 23672-7 |year= 2003 |pmid= 12716892 |doi= 10.1074/jbc.M302777200 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | vauthors=Li S, Whorton AR |title=Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols |journal=J. Biol. Chem. |volume=280 |issue= 20 |pages= 20102–10 |year= 2005 |pmid= 15769744 |doi= 10.1074/jbc.M413164200 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Kühne A, Kaiser R, Schirmer M, etal |title=Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan |journal=Pharmacogenet. Genomics |volume=17 |issue= 7 |pages= 505–17 |year= 2007 |pmid= 17558306 |doi= 10.1097/FPC.0b013e3280ea77cd }}
-*{{cite journal  | author=Li S, Whorton AR |title=Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols. |journal=J. Biol. Chem. |volume=280 |issue= 20 |pages= 20102-10 |year= 2005 |pmid= 15769744 |doi= 10.1074/jbc.M413164200 }}
-*{{cite journal  | author=Kühne A, Kaiser R, Schirmer M, ''et al.'' |title=Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan. |journal=Pharmacogenet. Genomics |volume=17 |issue= 7 |pages= 505-17 |year= 2007 |pmid= 17558306 |doi= 10.1097/FPC.0b013e3280ea77cd }}
 }}
 {{refend}}
-{{membrane-protein-stub}}
 {{Membrane transport proteins}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
 [[Category:Solute carrier family]]
-{{WikiDoc Sources}}
+{{membrane-protein-stub}}

SLC7A8: Difference between revisions

Latest revision as of 06:36, 11 September 2017

See also

References

Further reading

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