SLC4A8: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Electroneutral sodium bicarbonate exchanger 1''' is a [[protein]] that in humans is encoded by the ''SLC4A8'' [[gene]].<ref name="pmid11133997">{{cite journal | vauthors = Grichtchenko II, Choi I, Zhong X, Bray-Ward P, Russell JM, Boron WF | title = Cloning, characterization, and chromosomal mapping of a human electroneutral Na<sup>+</sup>-driven Cl<sup>−</sup>HCO<sub>3</sub> exchanger | journal = J Biol Chem | volume = 276 | issue = 11 | pages = 8358–63 | date = May 2001 | pmid = 11133997 | pmc =  | doi = 10.1074/jbc.C000716200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9498| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{GNF_Protein_box
* [[Solute carrier family]]
| image =
* [[cotransporter]]
| image_source =
| PDB =
| Name = Solute carrier family 4, sodium bicarbonate cotransporter, member 8
| HGNCid = 11034
| Symbol = SLC4A8
| AltSymbols =; NBC3; DKFZp761B2318; FLJ46462
| OMIM = 605024
| ECnumber = 
| Homologene = 68419
| MGIid = 1928745
| GeneAtlas_image1 = PBB_GE_SLC4A8_207056_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005452 |text = inorganic anion exchanger activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006820 |text = anion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9498
    | Hs_Ensembl = ENSG00000050438
    | Hs_RefseqProtein = NP_001035049
    | Hs_RefseqmRNA = NM_001039960
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 50071399
    | Hs_GenLoc_end = 50177915
    | Hs_Uniprot = 
    | Mm_EntrezGene = 59033
    | Mm_Ensembl = ENSMUSG00000023032
    | Mm_RefseqmRNA = NM_001033218
    | Mm_RefseqProtein = NP_001028390
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 100589781
    | Mm_GenLoc_end = 100644023
    | Mm_Uniprot = 
  }}
}}
'''Solute carrier family 4, sodium bicarbonate cotransporter, member 8''', also known as '''SLC4A8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9498| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==See also==
SLC4A8 has been shown to [[Protein-protein interaction|interact]] with [[Sodium-hydrogen antiporter 3 regulator 1]]<ref name="pmid12444018">{{cite journal | vauthors = Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I | title = The COOH termini of NBC3 and the 56-kDa H<sup>+</sup>-ATPase subunit are PDZ motifs involved in their interaction | journal = Am. J. Physiol., Cell Physiol. | volume = 284 | issue = 3 | pages = C667–73 | date = March 2003 | pmid = 12444018 | doi = 10.1152/ajpcell.00225.2002 }}</ref><ref name="pmid12403779">{{cite journal | vauthors = Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I | title = The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO<sub>3</sub><sup>−</sup> salvage transporter human Na<sup>+</sup>-HCO<sub>3</sub><sup>−</sup> cotransport isoform 3 | journal = J. Biol. Chem. | volume = 277 | issue = 52 | pages = 50503–9 | date = December 2002 | pmid = 12403779 | doi = 10.1074/jbc.M201862200 }}</ref> and [[Cystic fibrosis transmembrane conductance regulator]].<ref name=pmid12403779/>
* [[Solute carrier family]]


==References==
== References ==
{{reflist|2}}
{{reflist}}
{{Clear}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Soleimani M | title = Na<sup>+</sup>:HCO<sub>3</sub><sup>−</sup> cs (NBC): expression and regulation in the kidney | journal = J. Nephrol. | volume = 15 Suppl 5 | issue =  | pages = S32–40 | year = 2002 | pmid = 12027220 | doi =  }}
| citations =
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Soleimani M |title=Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. |journal=J. Nephrol. |volume=15 Suppl 5 |issue=  |pages= S32-40 |year= 2002 |pmid= 12027220 |doi=  }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
* {{cite journal | vauthors = Loiselle FB, Morgan PE, Alvarez BV, Casey JR | title = Regulation of the human NBC3 Na<sup>+</sup>/HCO<sub>3</sub><sup>−</sup> cotransporter by carbonic anhydrase II and PKA | journal = Am. J. Physiol., Cell Physiol. | volume = 286 | issue = 6 | pages = C1423–33 | year = 2004 | pmid = 14736710 | doi = 10.1152/ajpcell.00382.2003 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I | title = The COOH termini of NBC3 and the 56-kDa H<sup>+</sup>-ATPase subunit are PDZ motifs involved in their interaction | journal = Am. J. Physiol., Cell Physiol. | volume = 284 | issue = 3 | pages = C667–73 | year = 2003 | pmid = 12444018 | doi = 10.1152/ajpcell.00225.2002 }}
*{{cite journal | author=Loiselle FB, Morgan PE, Alvarez BV, Casey JR |title=Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA. |journal=Am. J. Physiol., Cell Physiol. |volume=286 |issue= 6 |pages= C1423-33 |year= 2004 |pmid= 14736710 |doi= 10.1152/ajpcell.00382.2003 }}
* {{cite journal | vauthors = Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I | title = The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO<sub>3</sub><sup>−</sup> salvage transporter human Na<sup>+</sup>-HCO<sub>3</sub><sup>−</sup> cotransport isoform 3 | journal = J. Biol. Chem. | volume = 277 | issue = 52 | pages = 50503–9 | year = 2003 | pmid = 12403779 | doi = 10.1074/jbc.M201862200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Gresz V, Kwon TH, Vorum H, Zelles T, Kurtz I, Steward MC, Aalkjaer C, Nielsen S | title = Immunolocalization of electroneutral Na<sup>+</sup>-HCO cotransporters in human and rat salivary glands | journal = Am. J. Physiol. Gastrointest. Liver Physiol. | volume = 283 | issue = 2 | pages = G473–80 | year = 2002 | pmid = 12121896 | doi = 10.1152/ajpgi.00421.2001 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Amlal H, Burnham CE, Soleimani M | title = Characterization of Na<sup>+</sup>/HCO<sub>3</sub><sup>−</sup> cotransporter isoform NBC-3 | journal = Am. J. Physiol. | volume = 276 | issue = 6 Pt 2 | pages = F903–13 | year = 1999 | pmid = 10362779 | doi =  }}
*{{cite journal  | author=Pushkin A, Abuladze N, Newman D, ''et al.'' |title=The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction. |journal=Am. J. Physiol., Cell Physiol. |volume=284 |issue= 3 |pages= C667-73 |year= 2003 |pmid= 12444018 |doi= 10.1152/ajpcell.00225.2002 }}
* {{cite journal | vauthors = Pushkin A, Abuladze N, Lee I, Newman D, Hwang J, Kurtz I | title = Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family | journal = J. Biol. Chem. | volume = 274 | issue = 23 | pages = 16569–75 | year = 1999 | pmid = 10347222 | doi = 10.1074/jbc.274.23.16569 }}
*{{cite journal | author=Park M, Ko SB, Choi JY, ''et al.'' |title=The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50503-9 |year= 2003 |pmid= 12403779 |doi= 10.1074/jbc.M201862200 }}
* {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 5 | issue = 5 | pages = 277–86 | year = 1999 | pmid = 9872452 | doi = 10.1093/dnares/5.5.277 }}
*{{cite journal | author=Gresz V, Kwon TH, Vorum H, ''et al.'' |title=Immunolocalization of electroneutral Na(+)-HCO cotransporters in human and rat salivary glands. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=283 |issue= 2 |pages= G473-80 |year= 2002 |pmid= 12121896 |doi= 10.1152/ajpgi.00421.2001 }}
{{refend}} {{Solute carrier family|bg|bg0}}
*{{cite journal | author=Grichtchenko II, Choi I, Zhong X, ''et al.'' |title=Cloning, characterization, and chromosomal mapping of a human electroneutral Na(+)-driven Cl-HCO3 exchanger. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 8358-63 |year= 2001 |pmid= 11133997 |doi= 10.1074/jbc.C000716200 }}
 
*{{cite journal  | author=Amlal H, Burnham CE, Soleimani M |title=Characterization of Na+/HCO-3 cotransporter isoform NBC-3. |journal=Am. J. Physiol. |volume=276 |issue= 6 Pt 2 |pages= F903-13 |year= 1999 |pmid= 10362779 |doi=  }}
[[Category:Solute carrier family]]
*{{cite journal | author=Pushkin A, Abuladze N, Lee I, ''et al.'' |title=Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family. |journal=J. Biol. Chem. |volume=274 |issue= 23 |pages= 16569-75 |year= 1999 |pmid= 10347222 |doi= }}
 
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277-86 |year= 1999 |pmid= 9872452 |doi= }}
}}
{{refend}}


{{membrane-protein-stub}}
{{membrane-protein-stub}}
{{Membrane transport proteins}}
[[Category:Solute carrier family]]
{{WikiDoc Sources}}

Latest revision as of 15:43, 8 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Electroneutral sodium bicarbonate exchanger 1 is a protein that in humans is encoded by the SLC4A8 gene.[1][2]

See also

Interactions

SLC4A8 has been shown to interact with Sodium-hydrogen antiporter 3 regulator 1[3][4] and Cystic fibrosis transmembrane conductance regulator.[4]

References

  1. ↑ Grichtchenko II, Choi I, Zhong X, Bray-Ward P, Russell JM, Boron WF (May 2001). "Cloning, characterization, and chromosomal mapping of a human electroneutral Na+-driven Cl−HCO3 exchanger". J Biol Chem. 276 (11): 8358–63. doi:10.1074/jbc.C000716200. PMID 11133997.
  2. ↑ "Entrez Gene: SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8".
  3. ↑ Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (March 2003). "The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018.
  4. ↑ 4.0 4.1 Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (December 2002). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3− salvage transporter human Na+-HCO3− cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.

Further reading

  • Soleimani M (2002). "Na+:HCO3− cs (NBC): expression and regulation in the kidney". J. Nephrol. 15 Suppl 5: S32–40. PMID 12027220.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Loiselle FB, Morgan PE, Alvarez BV, Casey JR (2004). "Regulation of the human NBC3 Na+/HCO3− cotransporter by carbonic anhydrase II and PKA". Am. J. Physiol., Cell Physiol. 286 (6): C1423–33. doi:10.1152/ajpcell.00382.2003. PMID 14736710.
  • Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (2003). "The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018.
  • Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (2003). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3− salvage transporter human Na+-HCO3− cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.
  • Gresz V, Kwon TH, Vorum H, Zelles T, Kurtz I, Steward MC, Aalkjaer C, Nielsen S (2002). "Immunolocalization of electroneutral Na+-HCO cotransporters in human and rat salivary glands". Am. J. Physiol. Gastrointest. Liver Physiol. 283 (2): G473–80. doi:10.1152/ajpgi.00421.2001. PMID 12121896.
  • Amlal H, Burnham CE, Soleimani M (1999). "Characterization of Na+/HCO3− cotransporter isoform NBC-3". Am. J. Physiol. 276 (6 Pt 2): F903–13. PMID 10362779.
  • Pushkin A, Abuladze N, Lee I, Newman D, Hwang J, Kurtz I (1999). "Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family". J. Biol. Chem. 274 (23): 16569–75. doi:10.1074/jbc.274.23.16569. PMID 10347222.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.


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