RGS10: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Regulator of G-protein signaling 10''' is a [[protein]] that in humans is encoded by the ''RGS10'' [[gene]].<ref name="pmid8774883">{{cite journal | vauthors = Hunt TW, Fields TA, Casey PJ, Peralta EG | title = RGS10 is a selective activator of G alpha i GTPase activity | journal = Nature | volume = 383 | issue = 6596 | pages = 175–7 | date = Sep 1996 | pmid = 8774883 | pmc = | doi = 10.1038/383175a0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RGS10 regulator of G-protein signalling 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6001| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_RGS10_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dlr.
| PDB = {{PDB2|2dlr}}, {{PDB2|2i59}}, {{PDB2|2ihb}}
| Name = Regulator of G-protein signalling 10
| HGNCid = 9992
| Symbol = RGS10
| AltSymbols =;
| OMIM = 602856
| ECnumber = 
| Homologene = 37710
| MGIid = 1915115
| GeneAtlas_image1 = PBB_GE_RGS10_204319_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RGS10_204316_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}
| Component =
| Process = {{GNF_GO|id=GO:0009968 |text = negative regulation of signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6001
    | Hs_Ensembl = ENSG00000148908
    | Hs_RefseqProtein = NP_001005339
    | Hs_RefseqmRNA = NM_001005339
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 121249330
    | Hs_GenLoc_end = 121292212
    | Hs_Uniprot = O43665
    | Mm_EntrezGene = 67865
    | Mm_Ensembl = ENSMUSG00000030844
    | Mm_RefseqmRNA = NM_026418
    | Mm_RefseqProtein = NP_080694
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 128164773
    | Mm_GenLoc_end = 128209320
    | Mm_Uniprot = Q32MD7
  }}
}}
'''Regulator of G-protein signalling 10''', also known as '''RGS10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RGS10 regulator of G-protein signalling 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6001| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: RGS10 regulator of G-protein signalling 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6001| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
RGS10 has been shown to [[Protein-protein interaction|interact]] with [[SAP18]]<ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref> and [[GNAI3]].<ref name=pmid8774883 />
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Popov S, Yu K, Kozasa T, Wilkie TM | title = The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 14 | pages = 7216–20 | date = Jul 1997 | pmid = 9207071 | pmc = 23796 | doi = 10.1073/pnas.94.14.7216 }}
| citations =
* {{cite journal | vauthors = Tu Y, Wang J, Ross EM | title = Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits | journal = Science | volume = 278 | issue = 5340 | pages = 1132–5 | date = Nov 1997 | pmid = 9353196 | doi = 10.1126/science.278.5340.1132 }}
*{{cite journal | author=Hunt TW, Fields TA, Casey PJ, Peralta EG |title=RGS10 is a selective activator of G alpha i GTPase activity. |journal=Nature |volume=383 |issue= 6596 |pages= 175-7 |year= 1996 |pmid= 8774883 |doi= 10.1038/383175a0 }}
* {{cite journal | vauthors = Tu Y, Popov S, Slaughter C, Ross EM | title = Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 53 | pages = 38260–7 | date = Dec 1999 | pmid = 10608901 | doi = 10.1074/jbc.274.53.38260 }}
*{{cite journal  | author=Popov S, Yu K, Kozasa T, Wilkie TM |title=The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 14 |pages= 7216-20 |year= 1997 |pmid= 9207071 |doi= }}
* {{cite journal | vauthors = Popov SG, Krishna UM, Falck JR, Wilkie TM | title = Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity | journal = The Journal of Biological Chemistry | volume = 275 | issue = 25 | pages = 18962–8 | date = Jun 2000 | pmid = 10747990 | doi = 10.1074/jbc.M001128200 }}
*{{cite journal | author=Tu Y, Wang J, Ross EM |title=Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits. |journal=Science |volume=278 |issue= 5340 |pages= 1132-5 |year= 1997 |pmid= 9353196 |doi= }}
* {{cite journal | vauthors = Chatterjee TK, Fisher RA | title = Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs | journal = The Journal of Biological Chemistry | volume = 275 | issue = 31 | pages = 24013–21 | date = Aug 2000 | pmid = 10791963 | doi = 10.1074/jbc.M002082200 }}
*{{cite journal | author=Tu Y, Popov S, Slaughter C, Ross EM |title=Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 38260-7 |year= 2000 |pmid= 10608901 |doi= }}
* {{cite journal | vauthors = Burgon PG, Lee WL, Nixon AB, Peralta EG, Casey PJ | title = Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10) | journal = The Journal of Biological Chemistry | volume = 276 | issue = 35 | pages = 32828–34 | date = Aug 2001 | pmid = 11443111 | doi = 10.1074/jbc.M100960200 }}
*{{cite journal | author=Popov SG, Krishna UM, Falck JR, Wilkie TM |title=Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 18962-8 |year= 2000 |pmid= 10747990 |doi= 10.1074/jbc.M001128200 }}
* {{cite journal | vauthors = Gagnon AW, Murray DL, Leadley RJ | title = Cloning and characterization of a novel regulator of G protein signalling in human platelets | journal = Cellular Signalling | volume = 14 | issue = 7 | pages = 595–606 | date = Jul 2002 | pmid = 11955952 | doi = 10.1016/S0898-6568(02)00012-8 }}
*{{cite journal | author=Chatterjee TK, Fisher RA |title=Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 24013-21 |year= 2000 |pmid= 10791963 |doi= 10.1074/jbc.M002082200 }}
* {{cite journal | vauthors = Castro-Fernández C, Conn PM | title = Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus | journal = Molecular and Cellular Endocrinology | volume = 191 | issue = 2 | pages = 149–56 | date = Jun 2002 | pmid = 12062898 | doi = 10.1016/S0303-7207(02)00082-5 }}
*{{cite journal | author=Burgon PG, Lee WL, Nixon AB, ''et al.'' |title=Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32828-34 |year= 2001 |pmid= 11443111 |doi= 10.1074/jbc.M100960200 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Gagnon AW, Murray DL, Leadley RJ |title=Cloning and characterization of a novel regulator of G protein signalling in human platelets. |journal=Cell. Signal. |volume=14 |issue= 7 |pages= 595-606 |year= 2002 |pmid= 11955952 |doi= }}
* {{cite journal | vauthors = Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS | title = Transcriptome analysis of human gastric cancer | journal = Mammalian Genome | volume = 16 | issue = 12 | pages = 942–54 | date = Dec 2005 | pmid = 16341674 | doi = 10.1007/s00335-005-0075-2 }}
*{{cite journal | author=Castro-Fernández C, Conn PM |title=Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus. |journal=Mol. Cell. Endocrinol. |volume=191 |issue= 2 |pages= 149-56 |year= 2003 |pmid= 12062898 |doi= }}
* {{cite journal | vauthors = Lee HK, Rhee KH, Kim CW, Hwang KY, Kim EE | title = Crystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3 | journal = Acta Crystallographica Section F | volume = 61 | issue = Pt 9 | pages = 831–3 | date = Sep 2005 | pmid = 16511171 | pmc = 1978115 | doi = 10.1107/S1744309105023602 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Oh JH, Yang JO, Hahn Y, ''et al.'' |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942-54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
*{{cite journal | author=Lee HK, Rhee KH, Kim CW, ''et al.'' |title=Crystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3. |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=61 |issue= Pt 9 |pages= 831-3 |year= 2006 |pmid= 16511171 |doi= 10.1107/S1744309105023602 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=6001}}
{{WikiDoc Sources}}
 
 
{{gene-10-stub}}

Latest revision as of 02:30, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Regulator of G-protein signaling 10 is a protein that in humans is encoded by the RGS10 gene.[1][2]

Function

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.[2]

Interactions

RGS10 has been shown to interact with SAP18[3] and GNAI3.[1]

References

  1. ↑ 1.0 1.1 Hunt TW, Fields TA, Casey PJ, Peralta EG (Sep 1996). "RGS10 is a selective activator of G alpha i GTPase activity". Nature. 383 (6596): 175–7. doi:10.1038/383175a0. PMID 8774883.
  2. ↑ 2.0 2.1 "Entrez Gene: RGS10 regulator of G-protein signalling 10".
  3. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=RGS10&oldid=1414396"