FGFBP1: Difference between revisions

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{{Infobox_gene}}
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'''Fibroblast growth factor-binding protein 1''' is a [[protein]] that in humans is encoded by the ''FGFBP1'' [[gene]].<ref name="pmid11148217">{{cite journal |vauthors=Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV | title = Fibroblast growth factor-binding protein is a novel partner for perlecan protein core | journal = J Biol Chem | volume = 276 | issue = 13 | pages = 10263–71 |date=Mar 2001 | pmid = 11148217 | pmc =  | doi = 10.1074/jbc.M011493200 }}</ref><ref name="pmid1885605">{{cite journal |vauthors=Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD | title = Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors | journal = J Biol Chem | volume = 266 | issue = 25 | pages = 16778–85 |date=Oct 1991 | pmid = 1885605 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9982| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Fibroblast growth factor binding protein 1
| HGNCid = 19695
| Symbol = FGFBP1
| AltSymbols =; FGFBP; HBP17
| OMIM = 607737
| ECnumber =
| Homologene = 3766
| MGIid = 1096350
  | GeneAtlas_image1 = PBB_GE_FGFBP1_205014_at_tn.png
| Function = {{GNF_GO|id=GO:0008201 |text = heparin binding}} {{GNF_GO|id=GO:0019838 |text = growth factor binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9982
    | Hs_Ensembl = ENSG00000137440
    | Hs_RefseqProtein = NP_005121
    | Hs_RefseqmRNA = NM_005130
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 15546290
    | Hs_GenLoc_end = 15549461
    | Hs_Uniprot = Q14512
    | Mm_EntrezGene = 14181
    | Mm_Ensembl = ENSMUSG00000048373
    | Mm_RefseqmRNA = NM_008009
    | Mm_RefseqProtein = NP_032035
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 44267106
    | Mm_GenLoc_end = 44270010
    | Mm_Uniprot = O70514
  }}
}}
'''Fibroblast growth factor binding protein 1''', also known as '''FGFBP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9982| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = FGFBP1, or HBP17, binds to both acidic (FGF1; MIM 131220) and basic (FGF2; MIM 134920) fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2; MIM 142461).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9982| accessdate = }}</ref>
| summary_text = FGFBP1, or HBP17, binds to both acidic (FGF1; MIM 131220) and basic (FGF2; MIM 134920) fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2; MIM 142461).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9982| accessdate = }}</ref>
}}
}}
==Interactions==
FGFBP1 has been shown to [[Protein–protein interaction|interaction]] with [[Perlecan]].<ref name=pmid11148217 />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Abuharbeid S, Czubayko F, Aigner A |title=The fibroblast growth factor-binding protein FGF-BP. |journal=Int. J. Biochem. Cell Biol. |volume=38 |issue= 9 |pages= 1463-8 |year= 2006 |pmid= 16324873 |doi= 10.1016/j.biocel.2005.10.017 }}
*{{cite journal  |vauthors=Abuharbeid S, Czubayko F, Aigner A |title=The fibroblast growth factor-binding protein FGF-BP. |journal=Int. J. Biochem. Cell Biol. |volume=38 |issue= 9 |pages= 1463–8 |year= 2006 |pmid= 16324873 |doi= 10.1016/j.biocel.2005.10.017 }}
*{{cite journal  | author=Lange LG, Sytkowski AJ, Vallee BL |title=Human liver alcohol dehydrogenase: purification, composition, and catalytic features. |journal=Biochemistry |volume=15 |issue= 21 |pages= 4687-93 |year= 1976 |pmid= 9982 |doi= }}
*{{cite journal  |vauthors=Lange LG, Sytkowski AJ, Vallee BL |title=Human liver alcohol dehydrogenase: purification, composition, and catalytic features. |journal=Biochemistry |volume=15 |issue= 21 |pages= 4687–93 |year= 1976 |pmid= 9982 |doi=10.1021/bi00666a023 }}
*{{cite journal  | author=Wu DQ, Kan MK, Sato GH, ''et al.'' |title=Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors. |journal=J. Biol. Chem. |volume=266 |issue= 25 |pages= 16778-85 |year= 1991 |pmid= 1885605 |doi= }}
*{{cite journal  |vauthors=Czubayko F, Liaudet-Coopman ED, Aigner A |title=A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. |journal=Nat. Med. |volume=3 |issue= 10 |pages= 1137–40 |year= 1997 |pmid= 9334727 |doi=10.1038/nm1097-1137 |display-authors=etal}}
*{{cite journal  | author=Czubayko F, Liaudet-Coopman ED, Aigner A, ''et al.'' |title=A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. |journal=Nat. Med. |volume=3 |issue= 10 |pages= 1137-40 |year= 1997 |pmid= 9334727 |doi=  }}
*{{cite journal  |vauthors=Wang XC, Chen JH, Crab JW, Sato JD |title=Purification of heparin-binding protein HBp17 and identification of HBp17 heparin binding site. |journal=Biochem. Mol. Biol. Int. |volume=46 |issue= 1 |pages= 81–7 |year= 1998 |pmid= 9784842 |doi=  10.1080/15216549800203582}}
*{{cite journal  | author=Wang XC, Chen JH, Crab JW, Sato JD |title=Purification of heparin-binding protein HBp17 and identification of HBp17 heparin binding site. |journal=Biochem. Mol. Biol. Int. |volume=46 |issue= 1 |pages= 81-7 |year= 1998 |pmid= 9784842 |doi=  }}
*{{cite journal  |vauthors=Harris VK, Coticchia CM, Kagan BL |title=Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 10802–11 |year= 2000 |pmid= 10753873 |doi=10.1074/jbc.275.15.10802  |display-authors=etal}}
*{{cite journal  | author=Harris VK, Coticchia CM, Kagan BL, ''et al.'' |title=Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 10802-11 |year= 2000 |pmid= 10753873 |doi= }}
*{{cite journal  |vauthors=Sauter ER, Nesbit M, Tichansky D |title=Fibroblast growth factor-binding protein expression changes with disease progression in clinical and experimental human squamous epithelium. |journal=Int. J. Cancer |volume=92 |issue= 3 |pages= 374–81 |year= 2001 |pmid= 11291074 |doi=10.1002/ijc.1207 |display-authors=etal}}
*{{cite journal  | author=Mongiat M, Otto J, Oldershaw R, ''et al.'' |title=Fibroblast growth factor-binding protein is a novel partner for perlecan protein core. |journal=J. Biol. Chem. |volume=276 |issue= 13 |pages= 10263-71 |year= 2001 |pmid= 11148217 |doi= 10.1074/jbc.M011493200 }}
*{{cite journal  |vauthors=Chen JH, Wang XC, Sato JD |title=Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells. |journal=Cell Biol. Int. |volume=25 |issue= 6 |pages= 567–70 |year= 2001 |pmid= 11407864 |doi= 10.1006/cbir.2000.0688 }}
*{{cite journal  | author=Sauter ER, Nesbit M, Tichansky D, ''et al.'' |title=Fibroblast growth factor-binding protein expression changes with disease progression in clinical and experimental human squamous epithelium. |journal=Int. J. Cancer |volume=92 |issue= 3 |pages= 374-81 |year= 2001 |pmid= 11291074 |doi=  }}
*{{cite journal  |vauthors=Tassi E, Al-Attar A, Aigner A |title=Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 40247–53 |year= 2001 |pmid= 11509569 |doi= 10.1074/jbc.M104933200 |display-authors=etal}}
*{{cite journal  | author=Chen JH, Wang XC, Sato JD |title=Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells. |journal=Cell Biol. Int. |volume=25 |issue= 6 |pages= 567-70 |year= 2001 |pmid= 11407864 |doi= 10.1006/cbir.2000.0688 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Tassi E, Al-Attar A, Aigner A, ''et al.'' |title=Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 40247-53 |year= 2001 |pmid= 11509569 |doi= 10.1074/jbc.M104933200 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Beer HD, Bittner M, Niklaus G |title=The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. |journal=Oncogene |volume=24 |issue= 34 |pages= 5269–77 |year= 2005 |pmid= 15806171 |doi= 10.1038/sj.onc.1208560 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Beer HD, Bittner M, Niklaus G, ''et al.'' |title=The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. |journal=Oncogene |volume=24 |issue= 34 |pages= 5269-77 |year= 2005 |pmid= 15806171 |doi= 10.1038/sj.onc.1208560 }}
*{{cite journal  |vauthors=Xie B, Tassi E, Swift MR |title=Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. |journal=J. Biol. Chem. |volume=281 |issue= 2 |pages= 1137–44 |year= 2006 |pmid= 16257968 |doi= 10.1074/jbc.M510754200 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |vauthors=Ray PE, Tassi E, Liu XH, Wellstein A |title=Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome. |journal=Am. J. Physiol. Regul. Integr. Comp. Physiol. |volume=290 |issue= 1 |pages= R105–13 |year= 2006 |pmid= 16352855 |doi= 10.1152/ajpregu.00492.2005 }}
*{{cite journal  | author=Xie B, Tassi E, Swift MR, ''et al.'' |title=Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. |journal=J. Biol. Chem. |volume=281 |issue= 2 |pages= 1137-44 |year= 2006 |pmid= 16257968 |doi= 10.1074/jbc.M510754200 }}
*{{cite journal  |vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}}
*{{cite journal  | author=Ray PE, Tassi E, Liu XH, Wellstein A |title=Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome. |journal=Am. J. Physiol. Regul. Integr. Comp. Physiol. |volume=290 |issue= 1 |pages= R105-13 |year= 2006 |pmid= 16352855 |doi= 10.1152/ajpregu.00492.2005 }}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 04:47, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.[1][2][3]

FGFBP1, or HBP17, binds to both acidic (FGF1; MIM 131220) and basic (FGF2; MIM 134920) fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2; MIM 142461).[supplied by OMIM][3]

Interactions

FGFBP1 has been shown to interaction with Perlecan.[1]

References

  1. ↑ 1.0 1.1 Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV (Mar 2001). "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J Biol Chem. 276 (13): 10263–71. doi:10.1074/jbc.M011493200. PMID 11148217.
  2. ↑ Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Oct 1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". J Biol Chem. 266 (25): 16778–85. PMID 1885605.
  3. ↑ 3.0 3.1 "Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1".

Further reading



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