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{{Infobox_gene}}
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'''Ras GTPase-activating protein-binding protein 2''' is an [[enzyme]] that in humans is encoded by the ''G3BP2'' [[gene]].<ref name="pmid9734811">{{cite journal |vauthors=Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 3 | pages = 169–76 |date=December 1998 | pmid = 9734811 | pmc =  | doi =10.1093/dnares/5.3.169 }}</ref><ref name="pmid9575347">{{cite journal |vauthors=Kennedy D, Wood SA, Ramsdale T, Tam PP, Steiner KA, Mattick JS | title = Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif | journal = Biomed Pept Proteins Nucleic Acids | volume = 2 | issue = 3 | pages = 93–9 |date=June 1998 | pmid = 9575347 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: G3BP2 GTPase activating protein (SH3 domain) binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9908| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = GTPase activating protein (SH3 domain) binding protein 2
| HGNCid = 30291
| Symbol = G3BP2
| AltSymbols =;
| OMIM =
| ECnumber = 
| Homologene = 40792
  | MGIid = 2442040
| GeneAtlas_image1 = PBB_GE_G3BP2_208841_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_G3BP2_206383_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_G3BP2_208840_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0030159 |text = receptor signaling complex scaffold activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007253 |text = cytoplasmic sequestering of NF-kappaB}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0051028 |text = mRNA transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9908
    | Hs_Ensembl = ENSG00000138757
    | Hs_RefseqProtein = NP_036429
    | Hs_RefseqmRNA = NM_012297
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 76786991
    | Hs_GenLoc_end = 76817629
    | Hs_Uniprot = Q9UN86
    | Mm_EntrezGene = 23881
    | Mm_Ensembl = ENSMUSG00000029405
    | Mm_RefseqmRNA = NM_001080794
    | Mm_RefseqProtein = NP_001074263
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 93127364
    | Mm_GenLoc_end = 93158905
    | Mm_Uniprot = Q3TEL4
  }}
}}
'''GTPase activating protein (SH3 domain) binding protein 2''', also known as '''G3BP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: G3BP2 GTPase activating protein (SH3 domain) binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9908| accessdate = }}</ref>


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| summary_text =  
}}
}}
==Interactions==
G3BP2 has been shown to [[Protein-protein interaction|interact]] with [[IκBα]].<ref name=pmid10969074>{{cite journal |last=Prigent |first=M |authorlink= |author2=Barlat I|author3=Langen H|author4=Dargemont C |date=November 2000  |title=IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2 |journal=J. Biol. Chem. |volume=275 |issue=46 |pages=36441–9 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10969074 |doi = 10.1074/jbc.M004751200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  | author=Ewing RM |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948  |name-list-format=vanc| author2=Chu P  | author3=Elisma F  | display-authors=3  | last4=Li  | first4=Hongyan  | last5=Taylor  | first5=Paul  | last6=Climie  | first6=Shane  | last7=McBroom-Cerajewski  | first7=Linda  | last8=Robinson  | first8=Mark D  | last9=O'Connor  | first9=Liam }}
*{{cite journal  | author=Kim MM, Wiederschain D, Kennedy D, ''et al.'' |title=Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP). |journal=Oncogene |volume=26 |issue= 29 |pages= 4209-15 |year= 2007 |pmid= 17297477 |doi= 10.1038/sj.onc.1210212 }}
*{{cite journal  | author=Kim MM |title=Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP) |journal=Oncogene |volume=26 |issue= 29 |pages= 4209–15 |year= 2007 |pmid= 17297477 |doi= 10.1038/sj.onc.1210212 |name-list-format=vanc| author2=Wiederschain D  | author3=Kennedy D  | display-authors=3  | last4=Hansen  | first4=E  | last5=Yuan  | first5=Z-M }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |name-list-format=vanc| author2=Blagoev B  | author3=Gnad F  | display-authors=3  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal  | author=Ong SE, Mittler G, Mann M |title=Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. |journal=Nat. Methods |volume=1 |issue= 2 |pages= 119-26 |year= 2005 |pmid= 15782174 |doi= 10.1038/nmeth715 }}
*{{cite journal  |vauthors=Ong SE, Mittler G, Mann M |title=Identifying and quantifying in vivo methylation sites by heavy methyl SILAC |journal=Nat. Methods |volume=1 |issue= 2 |pages= 119–26 |year= 2005 |pmid= 15782174 |doi= 10.1038/nmeth715 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal  | author=Ballif BA |title=Phosphoproteomic analysis of the developing mouse brain |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |name-list-format=vanc| author2=Villén J  | author3=Beausoleil SA  | display-authors=3  | last4=Schwartz  | first4=D  | last5=Gygi  | first5=SP }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Prigent M, Barlat I, Langen H, Dargemont C |title=IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2. |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 36441-9 |year= 2000 |pmid= 10969074 |doi= 10.1074/jbc.M004751200 }}
*{{cite journal  |vauthors=Prigent M, Barlat I, Langen H, Dargemont C |title=IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2 |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 36441–9 |year= 2000 |pmid= 10969074 |doi= 10.1074/jbc.M004751200 }}
*{{cite journal  | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169-76 |year= 1998 |pmid= 9734811 |doi=  }}
*{{cite journal  | author=Yu W |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |name-list-format=vanc| author2=Andersson B  | author3=Worley KC  | display-authors=3 | last4=Muzny  | first4=DM  | last5=Ding  | first5=Y | last6=Liu | first6=W | last7=Ricafrente  | first7=JY  | last8=Wentland  | first8=MA  | last9=Lennon  | first9=G }}
*{{cite journal  | author=Kennedy D, Wood SA, Ramsdale T, ''et al.'' |title=Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif. |journal=Biomed. Pept. Proteins Nucleic Acids |volume=2 |issue= 3 |pages= 93-9 |year= 1998 |pmid= 9575347 |doi=  }}
*{{cite journal  | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |name-list-format=vanc| author2=Wentland MA  | author3=Ricafrente JY  | display-authors=3  | last4=Liu  | first4=W  | last5=Gibbs  | first5=RA }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 08:34, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras GTPase-activating protein-binding protein 2 is an enzyme that in humans is encoded by the G3BP2 gene.[1][2][3]


Interactions

G3BP2 has been shown to interact with IκBα.[4]

References

  1. ↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  2. ↑ Kennedy D, Wood SA, Ramsdale T, Tam PP, Steiner KA, Mattick JS (June 1998). "Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif". Biomed Pept Proteins Nucleic Acids. 2 (3): 93–9. PMID 9575347.
  3. ↑ "Entrez Gene: G3BP2 GTPase activating protein (SH3 domain) binding protein 2".
  4. ↑ Prigent, M; Barlat I; Langen H; Dargemont C (November 2000). "IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2". J. Biol. Chem. UNITED STATES. 275 (46): 36441–9. doi:10.1074/jbc.M004751200. ISSN 0021-9258. PMID 10969074.

Further reading



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