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'''Leucine-rich repeats and immunoglobulin-like domains protein 1''' is a [[protein]] that in humans is encoded by the ''LRIG1'' [[gene]].<ref name="pmid11414704">{{cite journal |vauthors=Nilsson J, Vallbo C, Guo D, Golovleva I, Hallberg B, Henriksson R, Hedman H | title = Cloning, characterization, and expression of human LIG1 | journal = Biochem Biophys Res Commun | volume = 284 | issue = 5 | pages = 1155–61 |date=Jun 2001 | pmid = 11414704 | pmc = | doi = 10.1006/bbrc.2001.5092 }}</ref><ref name="pmid12234026">{{cite journal |vauthors=Hedman H, Nilsson J, Guo D, Henriksson R | title = Is LRIG1 a tumour suppressor gene at chromosome 3p14.3? | journal = Acta Oncol | volume = 41 | issue = 4 | pages = 352–4 |date=Sep 2002 | pmid = 12234026 | pmc =  | doi =10.1080/028418602760169398 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LRIG1 leucine-rich repeats and immunoglobulin-like domains 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26018| accessdate = }}</ref>
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It encodes a [[transmembrane protein]] that has been shown to interact with receptor tyrosine kinases of the [[Epidermal growth factor receptor|EGFR]]-family<ref name="Gur">{{cite journal  | author=Gur G |title=LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation |journal=EMBO J. |volume=23 |issue= 16 |pages= 3270–81 |year= 2005 |pmid= 15282549 |doi= 10.1038/sj.emboj.7600342 | pmc=514515 |name-list-format=vanc| author2=Rubin C | author3=Katz M  | display-authors=3 | last4=Amit | first4=Ido | last5=Citri | first5=Ami | last6=Nilsson | first6=Jonas | last7=Amariglio  | first7=Ninette  | last8=Henriksson | first8=Roger  | last9=Rechavi  | first9=Gideon }}</ref>
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, [[C-MET|MET]]<ref name="Shattuck">{{cite journal  | author=Shattuck DL |title=LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy |journal=Mol. Cell. Biol. |volume=27 |issue= 5 |pages= 1934–46 |year= 2007 |pmid= 17178829 |doi= 10.1128/MCB.00757-06 | pmc=1820466  |name-list-format=vanc| author2=Miller JK  | author3=Laederich M  | display-authors=3  | last4=Funes  | first4=M.  | last5=Petersen  | first5=H. | last6=Carraway  | first6=K. L.  | last7=Sweeney  | first7=C. }}</ref> and [[RET proto-oncogene|RET]].<ref name="Ledda">{{cite journal  |vauthors=Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G |title=Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF |journal= J. Neurosci. |volume=28 |issue= 2 |pages= 39–49 |year= 2008 |pmid= 18171921 |doi=10.1523/JNEUROSCI.2196-07.2008 }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
  | PDB =  
  | Name = Leucine-rich repeats and immunoglobulin-like domains 1
  | HGNCid = 17360
  | Symbol = LRIG1
  | AltSymbols =; LIG1; DKFZP586O1624; LIG-1
  | OMIM = 608868
  | ECnumber =   
  | Homologene = 7380
  | MGIid = 107935
  | GeneAtlas_image1 = PBB_GE_LRIG1_211596_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
  | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26018
    | Hs_Ensembl = ENSG00000144749
    | Hs_RefseqProtein = NP_056356
    | Hs_RefseqmRNA = NM_015541
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 66511912
    | Hs_GenLoc_end = 66634125
    | Hs_Uniprot = Q96JA1
    | Mm_EntrezGene = 16206
    | Mm_Ensembl = ENSMUSG00000030029
    | Mm_RefseqmRNA = NM_008377
    | Mm_RefseqProtein = NP_032403
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 94569992
    | Mm_GenLoc_end = 94665608
    | Mm_Uniprot = P70193
  }}
}}
'''Leucine-rich repeats and immunoglobulin-like domains 1''', also known as '''LRIG1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LRIG1 leucine-rich repeats and immunoglobulin-like domains 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26018| accessdate = }}</ref>
 
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==Model organisms==
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: right;" |
|+ ''Lrig1'' knockout mouse phenotype
|-
! Characteristic!! Phenotype
|-
| [[Homozygote]] viability || bgcolor="#488ED3"|Normal
|-
| Fertility || bgcolor="#488ED3"|Normal
|-
| Body weight || bgcolor="#C40000"|Abnormal<ref name="Body weight">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBHE/weight-curves/ |title=Body weight data for Lrig1 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| [[Open Field (animal test)|Anxiety]] || bgcolor="#488ED3"|Normal
|-
| Neurological assessment || bgcolor="#488ED3"|Normal
|-
| Grip strength || bgcolor="#488ED3"|Normal
|-
| [[Hot plate test|Hot plate]] || bgcolor="#488ED3"|Normal
|-
| [[Dysmorphology]] || bgcolor="#C40000"|Abnormal<ref name="Dysmorphology">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBHE/dysmorphology/ |title=Dysmorphology data for Lrig1 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
|-
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
|-
| [[Auditory brainstem response]] || bgcolor="#C40000"|Abnormal
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#C40000"|Abnormal<ref name="DEXA">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBHE/body-composition-dexa/ |title=DEXA data for Lrig1 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| [[Radiography]] || bgcolor="#C40000"|Abnormal<ref name="Radiography">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBHE/x-ray-imaging/ |title=Radiography data for Lrig1 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| Body temperature || bgcolor="#488ED3"|Normal
|-
| Eye morphology || bgcolor="#488ED3"|Normal
|-
| [[Clinical chemistry]] || bgcolor="#C40000"|Abnormal<ref name="Clinical chemistry">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBHE/plasma-chemistry/ |title=Clinical chemistry data for Lrig1 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| [[Blood plasma|Plasma]] [[immunoglobulin]]s || bgcolor="#488ED3"|Normal
|-
| [[Haematology]] || bgcolor="#488ED3"|Normal
|-
| [[Micronucleus test]] || bgcolor="#488ED3"|Normal
|-
| Heart weight || bgcolor="#488ED3"|Normal
|-
| Tail epidermis wholemount || bgcolor="#C40000"|Abnormal
|-
| Skin Histopathology || bgcolor="#C40000"|Abnormal
|-
| Eye Histopathology || bgcolor="#488ED3"|Normal
|-
| ''[[Salmonella]]'' infection || bgcolor="#C40000"|Abnormal<ref name="''Salmonella'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBHE/salmonella-challenge/ |title=''Salmonella'' infection data for Lrig1 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| ''[[Citrobacter]]'' infection || bgcolor="#C40000"|Abnormal<ref name="''Citrobacter'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBHE/citrobacter-challenge/ |title=''Citrobacter'' infection data for Lrig1 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| colspan=2; style="text-align: center;" | All tests and analysis from<ref name="mgp_reference">{{cite journal | doi = 10.1111/j.1755-3768.2010.4142.x | title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice | year = 2010 | author = Gerdin AK | journal = Acta Ophthalmologica | volume = 88 | pages =  925–7 }}</ref><ref>[http://www.sanger.ac.uk/mouseportal/ Mouse Resources Portal], Wellcome Trust Sanger Institute.</ref>
|}
[[Model organism]]s have been used in the study of LRIG1 function. A conditional [[knockout mouse]] line, called ''Lrig1<sup>tm1a(EUCOMM)Wtsi</sup>''<ref name="allele_ref">{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Lrig1 |title=International Knockout Mouse Consortium}}</ref><ref name="mgi_allele_ref">{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4431776 |title=Mouse Genome Informatics}}</ref> was generated as part of the [[International Knockout Mouse Consortium]] program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.<ref name="pmid21677750">{{Cite journal
| last1 = Skarnes |first1 =W. C.
| doi = 10.1038/nature10163
| last2 = Rosen | first2 = B.
| last3 = West | first3 = A. P.
| last4 = Koutsourakis | first4 = M.
| last5 = Bushell | first5 = W.
| last6 = Iyer | first6 = V.
| last7 = Mujica | first7 = A. O.
| last8 = Thomas | first8 = M.
| last9 = Harrow | first9 = J.
| last10 = Cox | first10 = T.
| last11 = Jackson | first11 = D.
| last12 = Severin | first12 = J.
| last13 = Biggs | first13 = P.
| last14 = Fu | first14 = J.
| last15 = Nefedov | first15 = M.
| last16 = De Jong | first16 = P. J.
| last17 = Stewart | first17 = A. F.
| last18 = Bradley | first18 = A.
| title = A conditional knockout resource for the genome-wide study of mouse gene function
| journal = Nature
| volume = 474
| issue = 7351
| pages = 337–342
| year = 2011
| pmid = 21677750
| pmc =3572410
}}</ref><ref name="mouse_library">{{cite journal | doi = 10.1038/474262a | title = Mouse library set to be knockout | year = 2011 | author = Dolgin E | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | pmid = 21677718 }}</ref><ref name="mouse_for_all_reasons">{{cite journal | doi = 10.1016/j.cell.2006.12.018 | title = A Mouse for All Reasons | year = 2007 | journal = Cell | volume = 128 | pages = 9–13 | pmid = 17218247 |vauthors=Collins FS, Rossant J, Wurst W | issue = 1 }}</ref>
Male and female animals underwent a standardized [[phenotypic screen]] to determine the effects of deletion.<ref name="mgp_reference" /><ref name="pmid21722353">{{cite journal|vauthors=van der Weyden L, White JK, Adams DJ, Logan DW | title=The mouse genetics toolkit: revealing function and mechanism. | journal=Genome Biol | year= 2011 | volume= 12 | issue= 6 | pages= 224 | pmid=21722353 | doi=10.1186/gb-2011-12-6-224  | pmc=3218837}}</ref> Twenty five tests were carried out on homozygous [[mutant]] mice and ten significant abnormalities were observed, including decreased body weight and total body fat, scaly skin, abnormal hair shedding, a moderate degree of [[hearing impairment]], vertebral fusion, abnormal plasma chemistry and an increased susceptibility to [[bacterial infection]] (with both ''Salmonella'' and ''Citrobacter'').<ref name="mgp_reference" />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Suzuki Y, Sato N, Tohyama M, ''et al.'' |title=cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains. |journal=J. Biol. Chem. |volume=271 |issue= 37 |pages= 22522-7 |year= 1996 |pmid= 8798419 |doi= }}
*{{cite journal  | author=Suzuki Y |title=cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains |journal=J. Biol. Chem. |volume=271 |issue= 37 |pages= 22522–7 |year= 1996 |pmid= 8798419 |doi=10.1074/jbc.271.37.22522 |name-list-format=vanc| author2=Sato N  | author3=Tohyama M  | display-authors=3  | last4=Wanaka  | first4=A  | last5=Takagi  | first5=T  }}
*{{cite journal | author=Nilsson J, Vallbo C, Guo D, ''et al.'' |title=Cloning, characterization, and expression of human LIG1. |journal=Biochem. Biophys. Res. Commun. |volume=284 |issue= 5 |pages= 1155-61 |year= 2001 |pmid= 11414704 |doi= 10.1006/bbrc.2001.5092 }}
*{{cite journal  | author=Suzuki Y |title=Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia |journal=FEBS Lett. |volume=521 |issue= 1–3 |pages= 67–71 |year= 2002 |pmid= 12067728 |doi=10.1016/S0014-5793(02)02824-7 |name-list-format=vanc| author2=Miura H | author3=Tanemura A  | display-authors=3 | last4=Kobayashi  | first4=K  | last5=Kondoh  | first5=G  | last6=Sano  | first6=S  | last7=Ozawa  | first7=K  | last8=Inui  | first8=S  | last9=Nakata  | first9=A }}
*{{cite journal  | author=Suzuki Y, Miura H, Tanemura A, ''et al.'' |title=Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia. |journal=FEBS Lett. |volume=521 |issue= 1-3 |pages= 67-71 |year= 2002 |pmid= 12067728 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Hedman H, Nilsson J, Guo D, Henriksson R |title=Is LRIG1 a tumour suppressor gene at chromosome 3p14.3? |journal=Acta oncologica (Stockholm, Sweden) |volume=41 |issue= 4 |pages= 352-4 |year= 2002 |pmid= 12234026 |doi=  }}
*{{cite journal  |vauthors=Nilsson J, Starefeldt A, Henriksson R, Hedman H |title=LRIG1 protein in human cells and tissues |journal=Cell Tissue Res. |volume=312 |issue= 1 |pages= 65–71 |year= 2004 |pmid= 12684867 |doi= 10.1007/s00441-003-0697-1 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Thomasson M |title=LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT–PCR and immunohistochemical analysis |journal=Br. J. Cancer |volume=89 |issue= 7 |pages= 1285–9 |year= 2003 |pmid= 14520461 |doi= 10.1038/sj.bjc.6601208 | pmc=2394322  |name-list-format=vanc| author2=Hedman H  | author3=Guo D  | display-authors=3  | last4=Ljungberg  | first4=B  | last5=Henriksson  | first5=R }}
*{{cite journal  | author=Nilsson J, Starefeldt A, Henriksson R, Hedman H |title=LRIG1 protein in human cells and tissues. |journal=Cell Tissue Res. |volume=312 |issue= 1 |pages= 65-71 |year= 2004 |pmid= 12684867 |doi= 10.1007/s00441-003-0697-1 }}
*{{cite journal  | author=Gur G |title=LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation |journal=EMBO J. |volume=23 |issue= 16 |pages= 3270–81 |year= 2005 |pmid= 15282549 |doi= 10.1038/sj.emboj.7600342 | pmc=514515  |name-list-format=vanc| author2=Rubin C  | author3=Katz M  | display-authors=3  | last4=Amit  | first4=Ido  | last5=Citri  | first5=Ami  | last6=Nilsson  | first6=Jonas  | last7=Amariglio  | first7=Ninette  | last8=Henriksson  | first8=Roger  | last9=Rechavi  | first9=Gideon }}
*{{cite journal  | author=Thomasson M, Hedman H, Guo D, ''et al.'' |title=LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT--PCR and immunohistochemical analysis. |journal=Br. J. Cancer |volume=89 |issue= 7 |pages= 1285-9 |year= 2003 |pmid= 14520461 |doi= 10.1038/sj.bjc.6601208 }}
*{{cite journal  | author=Laederich MB |title=The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47050–6 |year= 2004 |pmid= 15345710 |doi= 10.1074/jbc.M409703200 |name-list-format=vanc| author2=Funes-Duran M  | author3=Yen L  | display-authors=3  | last4=Ingalla  | first4=E  | last5=Wu  | first5=X  | last6=Carraway Kl  | first6=3rd  | last7=Sweeney  | first7=C }}
*{{cite journal  | author=Gur G, Rubin C, Katz M, ''et al.'' |title=LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation. |journal=EMBO J. |volume=23 |issue= 16 |pages= 3270-81 |year= 2005 |pmid= 15282549 |doi= 10.1038/sj.emboj.7600342 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Laederich MB, Funes-Duran M, Yen L, ''et al.'' |title=The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47050-6 |year= 2004 |pmid= 15345710 |doi= 10.1074/jbc.M409703200 }}
*{{cite journal  | author=Ljuslinder I |title=Increased copy number at 3p14 in breast cancer |journal=Breast Cancer Res. |volume=7 |issue= 5 |pages= R719–27 |year= 2006 |pmid= 16168117 |doi= 10.1186/bcr1279 | pmc=1242137  |name-list-format=vanc| author2=Malmer B  | author3=Golovleva I  | display-authors=3  | last4=Thomasson  | first4=Marcus  | last5=Grankvist  | first5=Kjell  | last6=Höckenström  | first6=Thomas  | last7=Emdin  | first7=Stefan  | last8=Jonsson  | first8=Yvonne  | last9=Hedman  | first9=Håkan }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Jensen KB, Watt FM |title=Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 32 |pages= 11958–63 |year= 2006 |pmid= 16877544 |doi= 10.1073/pnas.0601886103 | pmc=1567680 }}
*{{cite journal  | author=Ljuslinder I, Malmer B, Golovleva I, ''et al.'' |title=Increased copy number at 3p14 in breast cancer. |journal=Breast Cancer Res. |volume=7 |issue= 5 |pages= R719-27 |year= 2006 |pmid= 16168117 |doi= 10.1186/bcr1279 }}
*{{cite journal  | author=Shattuck DL |title=LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy |journal=Mol. Cell. Biol. |volume=27 |issue= 5 |pages= 1934–46 |year= 2007 |pmid= 17178829 |doi= 10.1128/MCB.00757-06 | pmc=1820466  |name-list-format=vanc| author2=Miller JK  | author3=Laederich M  | display-authors=3  | last4=Funes  | first4=M.  | last5=Petersen  | first5=H.  | last6=Carraway  | first6=K. L.  | last7=Sweeney  | first7=C. }}
*{{cite journal  | author=Jensen KB, Watt FM |title=Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 32 |pages= 11958-63 |year= 2006 |pmid= 16877544 |doi= 10.1073/pnas.0601886103 }}
*{{cite journal  | author=Shattuck DL, Miller JK, Laederich M, ''et al.'' |title=LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy. |journal=Mol. Cell. Biol. |volume=27 |issue= 5 |pages= 1934-46 |year= 2007 |pmid= 17178829 |doi= 10.1128/MCB.00757-06 }}
}}
}}
{{refend}}
{{refend}}


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[[Category:Genes mutated in mice]]

Latest revision as of 22:21, 5 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene.[1][2][3] It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR-family[4] , MET[5] and RET.[6]


Model organisms

Model organisms have been used in the study of LRIG1 function. A conditional knockout mouse line, called Lrig1tm1a(EUCOMM)Wtsi[16][17] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[18][19][20]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[14][21] Twenty five tests were carried out on homozygous mutant mice and ten significant abnormalities were observed, including decreased body weight and total body fat, scaly skin, abnormal hair shedding, a moderate degree of hearing impairment, vertebral fusion, abnormal plasma chemistry and an increased susceptibility to bacterial infection (with both Salmonella and Citrobacter).[14]

References

  1. ↑ Nilsson J, Vallbo C, Guo D, Golovleva I, Hallberg B, Henriksson R, Hedman H (Jun 2001). "Cloning, characterization, and expression of human LIG1". Biochem Biophys Res Commun. 284 (5): 1155–61. doi:10.1006/bbrc.2001.5092. PMID 11414704.
  2. ↑ Hedman H, Nilsson J, Guo D, Henriksson R (Sep 2002). "Is LRIG1 a tumour suppressor gene at chromosome 3p14.3?". Acta Oncol. 41 (4): 352–4. doi:10.1080/028418602760169398. PMID 12234026.
  3. ↑ "Entrez Gene: LRIG1 leucine-rich repeats and immunoglobulin-like domains 1".
  4. ↑ Gur G, Rubin C, Katz M, et al. (2005). "LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation". EMBO J. 23 (16): 3270–81. doi:10.1038/sj.emboj.7600342. PMC 514515. PMID 15282549.
  5. ↑ Shattuck DL, Miller JK, Laederich M, et al. (2007). "LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy". Mol. Cell. Biol. 27 (5): 1934–46. doi:10.1128/MCB.00757-06. PMC 1820466. PMID 17178829.
  6. ↑ Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G (2008). "Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF". J. Neurosci. 28 (2): 39–49. doi:10.1523/JNEUROSCI.2196-07.2008. PMID 18171921.
  7. ↑ "Body weight data for Lrig1". Wellcome Trust Sanger Institute.
  8. ↑ "Dysmorphology data for Lrig1". Wellcome Trust Sanger Institute.
  9. ↑ "DEXA data for Lrig1". Wellcome Trust Sanger Institute.
  10. ↑ "Radiography data for Lrig1". Wellcome Trust Sanger Institute.
  11. ↑ "Clinical chemistry data for Lrig1". Wellcome Trust Sanger Institute.
  12. ↑ "Salmonella infection data for Lrig1". Wellcome Trust Sanger Institute.
  13. ↑ "Citrobacter infection data for Lrig1". Wellcome Trust Sanger Institute.
  14. ↑ 14.0 14.1 14.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  15. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  16. ↑ "International Knockout Mouse Consortium".
  17. ↑ "Mouse Genome Informatics".
  18. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  19. ↑ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  20. ↑ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  21. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

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