TFG (gene): Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Protein TFG''' is a [[protein]] that in humans is encoded by the ''TFG'' [[gene]].<ref name="pmid9169129">{{cite journal | vauthors = Mencinger M, Panagopoulos I, Andreasson P, Lassen C, Mitelman F, Aman P | title = Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma | journal = Genomics | volume = 41 | issue = 3 | pages = 327–31 | date = May 1997 | pmid = 9169129 | pmc = | doi = 10.1006/geno.1997.4625 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TFG TRK-fused gene| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10342| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = TRK-fused gene
| HGNCid = 11758
| Symbol = TFG
| AltSymbols =; FLJ36137; TF6; TRKT3
| OMIM = 602498
| ECnumber = 
| Homologene = 4426
| MGIid = 1338041
| GeneAtlas_image1 = PBB_GE_TFG_217839_at_tn.png
| Function = {{GNF_GO|id=GO:0004714 |text = transmembrane receptor protein tyrosine kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10342
    | Hs_Ensembl = ENSG00000114354
    | Hs_RefseqProtein = NP_001007566
    | Hs_RefseqmRNA = NM_001007565
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 101910850
    | Hs_GenLoc_end = 101950500
    | Hs_Uniprot = Q92734
    | Mm_EntrezGene = 21787
    | Mm_Ensembl = ENSMUSG00000022757
    | Mm_RefseqmRNA = NM_019678
    | Mm_RefseqProtein = NP_062652
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 56615283
    | Mm_GenLoc_end = 56642305
    | Mm_Uniprot = 
  }}
}}
'''TRK-fused gene''', also known as '''TFG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TFG TRK-fused gene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10342| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
TFG (gene) has been shown to [[Protein-protein interaction|interact]] with [[PLSCR1]].<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Sasaoka T, Kobayashi M | title = The functional significance of Shc in insulin signaling as a substrate of the insulin receptor | journal = Endocrine Journal | volume = 47 | issue = 4 | pages = 373–81 | date = Aug 2000 | pmid = 11075717 | doi = 10.1507/endocrj.47.373 }}
| citations =
* {{cite journal | vauthors = Greco A, Mariani C, Miranda C, Lupas A, Pagliardini S, Pomati M, Pierotti MA | title = The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain | journal = Molecular and Cellular Biology | volume = 15 | issue = 11 | pages = 6118–27 | date = Nov 1995 | pmid = 7565764 | pmc = 230863 | doi =  10.1128/mcb.15.11.6118}}
*{{cite journal | author=Sasaoka T, Kobayashi M |title=The functional significance of Shc in insulin signaling as a substrate of the insulin receptor. |journal=Endocr. J. |volume=47 |issue= 4 |pages= 373-81 |year= 2000 |pmid= 11075717 |doi= }}
* {{cite journal | vauthors = Gotoh N, Toyoda M, Shibuya M | title = Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation | journal = Molecular and Cellular Biology | volume = 17 | issue = 4 | pages = 1824–31 | date = Apr 1997 | pmid = 9121430 | pmc = 232029 | doi = 10.1128/mcb.17.4.1824}}
*{{cite journal | author=Greco A, Mariani C, Miranda C, ''et al.'' |title=The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. |journal=Mol. Cell. Biol. |volume=15 |issue= 11 |pages= 6118-27 |year= 1995 |pmid= 7565764 |doi=  }}
* {{cite journal | vauthors = Soltoff SP, Avraham H, Avraham S, Cantley LC | title = Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C | journal = The Journal of Biological Chemistry | volume = 273 | issue = 5 | pages = 2653–60 | date = Jan 1998 | pmid = 9446569 | doi = 10.1074/jbc.273.5.2653 }}
*{{cite journal | author=Gotoh N, Toyoda M, Shibuya M |title=Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 1824-31 |year= 1997 |pmid= 9121430 |doi= }}
* {{cite journal | vauthors = Walk SF, March ME, Ravichandran KS | title = Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc | journal = European Journal of Immunology | volume = 28 | issue = 8 | pages = 2265–75 | date = Aug 1998 | pmid = 9710204 | doi = 10.1002/(SICI)1521-4141(199808)28:08<2265::AID-IMMU2265>3.0.CO;2-P }}
*{{cite journal  | author=Mencinger M, Panagopoulos I, Andreasson P, ''et al.'' |title=Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma. |journal=Genomics |volume=41 |issue= 3 |pages= 327-31 |year= 1997 |pmid= 9169129 |doi= 10.1006/geno.1997.4625 }}
* {{cite journal | vauthors = Wary KK, Mariotti A, Zurzolo C, Giancotti FG | title = A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth | journal = Cell | volume = 94 | issue = 5 | pages = 625–34 | date = Sep 1998 | pmid = 9741627 | doi = 10.1016/S0092-8674(00)81604-9 }}
*{{cite journal | author=Soltoff SP, Avraham H, Avraham S, Cantley LC |title=Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C. |journal=J. Biol. Chem. |volume=273 |issue= 5 |pages= 2653-60 |year= 1998 |pmid= 9446569 |doi= }}
* {{cite journal | vauthors = Marchetto S, Fournier E, Beslu N, Aurran-Schleinitz T, Dubreuil P, Borg JP, Birnbaum D, Rosnet O | title = SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor | journal = Leukemia | volume = 13 | issue = 9 | pages = 1374–82 | date = Sep 1999 | pmid = 10482988 | doi = 10.1038/sj/leu/2401527 }}
*{{cite journal | author=Walk SF, March ME, Ravichandran KS |title=Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc. |journal=Eur. J. Immunol. |volume=28 |issue= 8 |pages= 2265-75 |year= 1998 |pmid= 9710204 |doi= }}
* {{cite journal | vauthors = Hernández L, Pinyol M, Hernández S, Beà S, Pulford K, Rosenwald A, Lamant L, Falini B, Ott G, Mason DY, Delsol G, Campo E | title = TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations | journal = Blood | volume = 94 | issue = 9 | pages = 3265–8 | date = Nov 1999 | pmid = 10556217 | doi =  }}
*{{cite journal | author=Wary KK, Mariotti A, Zurzolo C, Giancotti FG |title=A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. |journal=Cell |volume=94 |issue= 5 |pages= 625-34 |year= 1998 |pmid= 9741627 |doi= }}
* {{cite journal | vauthors = Nakajima K, Yamauchi K, Shigematsu S, Ikeo S, Komatsu M, Aizawa T, Hashizume K | title = Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells | journal = The Journal of Biological Chemistry | volume = 275 | issue = 27 | pages = 20880–6 | date = Jul 2000 | pmid = 10764799 | doi = 10.1074/jbc.M905410199 }}
*{{cite journal | author=Marchetto S, Fournier E, Beslu N, ''et al.'' |title=SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor. |journal=Leukemia |volume=13 |issue= 9 |pages= 1374-82 |year= 1999 |pmid= 10482988 |doi= }}
* {{cite journal | vauthors = Slack BE | title = The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase | journal = The Biochemical Journal | volume = 348 | issue = 2 | pages = 381–7 | date = Jun 2000 | pmid = 10816433 | pmc = 1221077 | doi = 10.1042/0264-6021:3480381 }}
*{{cite journal | author=Hernández L, Pinyol M, Hernández S, ''et al.'' |title=TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations. |journal=Blood |volume=94 |issue= 9 |pages= 3265-8 |year= 1999 |pmid= 10556217 |doi=  }}
* {{cite journal | vauthors = Schaak S, Cussac D, Cayla C, Devedjian JC, Guyot R, Paris H, Denis C | title = Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells | journal = Gut | volume = 47 | issue = 2 | pages = 242–50 | date = Aug 2000 | pmid = 10896916 | pmc = 1728001 | doi = 10.1136/gut.47.2.242 }}
*{{cite journal | author=Nakajima K, Yamauchi K, Shigematsu S, ''et al.'' |title=Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20880-6 |year= 2000 |pmid= 10764799 |doi= 10.1074/jbc.M905410199 }}
* {{cite journal | vauthors = Imokawa G, Kobayasi T, Miyagishi M | title = Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor | journal = The Journal of Biological Chemistry | volume = 275 | issue = 43 | pages = 33321–8 | date = Oct 2000 | pmid = 10921922 | doi = 10.1074/jbc.M004346200 }}
*{{cite journal | author=Slack BE |title=The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase. |journal=Biochem. J. |volume=348 Pt 2 |issue= |pages= 381-7 |year= 2000 |pmid= 10816433 |doi= }}
* {{cite journal | vauthors = Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | title = Protein-protein interaction panel using mouse full-length cDNAs | journal = Genome Research | volume = 11 | issue = 10 | pages = 1758–65 | date = Oct 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 }}
*{{cite journal | author=Schaak S, Cussac D, Cayla C, ''et al.'' |title=Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells. |journal=Gut |volume=47 |issue= 2 |pages= 242-50 |year= 2000 |pmid= 10896916 |doi= }}
* {{cite journal | vauthors = Hernández L, Beà S, Bellosillo B, Pinyol M, Falini B, Carbone A, Ott G, Rosenwald A, Fernández A, Pulford K, Mason D, Morris SW, Santos E, Campo E | title = Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity | journal = The American Journal of Pathology | volume = 160 | issue = 4 | pages = 1487–94 | date = Apr 2002 | pmid = 11943732 | pmc = 1867210 | doi = 10.1016/S0002-9440(10)62574-6 }}
*{{cite journal | author=Imokawa G, Kobayasi T, Miyagishi M |title=Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33321-8 |year= 2000 |pmid= 10921922 |doi= 10.1074/jbc.M004346200 }}
* {{cite journal | vauthors = Roccato E, Miranda C, Ranzi V, Gishizki M, Pierotti MA, Greco A | title = Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc | journal = British Journal of Cancer | volume = 87 | issue = 6 | pages = 645–53 | date = Sep 2002 | pmid = 12237775 | pmc = 2364237 | doi = 10.1038/sj.bjc.6600544 }}
*{{cite journal | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758-65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
* {{cite journal | vauthors = Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S | title = Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways | journal = Oncogene | volume = 22 | issue = 21 | pages = 3307–18 | date = May 2003 | pmid = 12761501 | doi = 10.1038/sj.onc.1206406 }}
*{{cite journal | author=Hernández L, Beà S, Bellosillo B, ''et al.'' |title=Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity. |journal=Am. J. Pathol. |volume=160 |issue= 4 |pages= 1487-94 |year= 2002 |pmid= 11943732 |doi= }}
*{{cite journal | author=Roccato E, Miranda C, Ranzi V, ''et al.'' |title=Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc. |journal=Br. J. Cancer |volume=87 |issue= 6 |pages= 645-53 |year= 2002 |pmid= 12237775 |doi= 10.1038/sj.bjc.6600544 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Matsuda A, Suzuki Y, Honda G, ''et al.'' |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307-18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|TFG}}
* {{UCSC gene details|TFG}}
 
 
{{gene-3-stub}}

Latest revision as of 11:47, 15 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein TFG is a protein that in humans is encoded by the TFG gene.[1][2]

Interactions

TFG (gene) has been shown to interact with PLSCR1.[3]

References

  1. Mencinger M, Panagopoulos I, Andreasson P, Lassen C, Mitelman F, Aman P (May 1997). "Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma". Genomics. 41 (3): 327–31. doi:10.1006/geno.1997.4625. PMID 9169129.
  2. "Entrez Gene: TFG TRK-fused gene".
  3. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

External links