Whipple's disease medical therapy: Difference between revisions

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Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].
==Medical Therapy==
==Medical Therapy==
*Pharmacologic medical therapy for Whipple's disease includes long-term antibiotics. Preferred regimens for initial therapy include Ceftriaxone or Penicillin G or Meropenem if allergic. One year of Trimethoprim-sulfamethoxazole is used for maintenance therapy. In case of sulfa allergy, the combination of Doxycycline and Hydroxychloroquine is used.  
*Pharmacologic medical therapy for Whipple's disease includes long-term [[Antibiotic|antibiotics]]. Preferred regimens for initial therapy include [[Ceftriaxone]] or Penicillin G or [[Meropenem]] if allergic. One year of [[Sulfamethoxazole-Trimethoprim|Trimethoprim-sulfamethoxazole]] is used for maintenance therapy. In case of [[sulfa allergy]], the combination of [[Doxycycline]] and [[Hydroxychloroquine]] is used.  


==== Classic Whipple's disease ====
==== Classic Whipple's disease ====

Revision as of 21:24, 2 November 2017

Whipple's disease Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Overview

The mainstay of treatment for Whipple's disease is systemic long-term antibiotic therapy. Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].

Medical Therapy

Classic Whipple's disease

  • Initial therapy
    • Preferred regimen (1): Ceftriaxone 2 g IV qd for 14 days
    • Preferred regimen (2): Penicillin G 2 million units IV q4h for 14 days
    • Alternative regimen (1): Meropenem 1 g IV q8h for 14 days
  • Maintenance therapy

CNS infection

  • Initial therapy
    • Preferred regimen (1): Ceftriaxone 2 g IV qd for 14-28 days
    • Preferred regimen (2): Penicillin G 4 million units IV q4h for 14-28 days
    • Alternative regimen (1): Meropenem 1 g IV q8h for 14-28 days
  • Maintenance therapy

Endocarditis

  • Initial therapy
    • Preferred regimen (1): Penicillin G 2 million units IV q4h for 28 days
    • Preferred regimen (2): Ceftriaxone 2 g IV qd for 28 days
    • Alternative regimen (1): Meropenem 1 g IV q8h for 28 days
  • Maintenance therapy

Relapse

  • Initial therapy
    • Preferred regimen (1): Penicillin G 4 million units IV q4h for 28 days
    • Preferred regimen (2): Ceftriaxone 2 g IV qd for 28 days
  • Maintenance therapy

References


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