Sandbox:Amd: Difference between revisions

Revision as of 20:17, 25 September 2017

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Disease	Clinical history/findings							Causes	Investigations/ Laboratory findings
	Hypotension	Skin pigmentation/ findings	Fatigue	Anorexia/ Weightloss	Abdominal pain	Muscle weakness	Other history/ findings	Causes	Hypo natremia	Cortisol levels	Gold Standard
Differentiating amongst adrenal insufficiencies
Primary adrenal insufficiency	✔	✔	✔	✔	✔	✔		Autoimmune/idiopathic Infections- Tuberculosis, histoplasmosis	✔	↓	Cosyntropin/ ACTH stimulation test
Secondary adrenal insufficiency	✔	-–	✔	✔	-–			Hypopituitarism- Tumors, infections. hemorrhage/trauma Drugs- Chronic steroid therapy and its withdrawal, Opiates Genetic- Combined pituitary hormone deficiency (CPHD), POMC (Proopiomelanocortin) gene deficiency	-–	Normal
Acute adrenal insufficiency	↓↓	±	✔	✔	✔	±	Signs of shock Altered mental status/ Loss of consciousness/ Coma Fever	Infection Tumor
Differentiating Adrenal Insufficiency from other diseases

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 Weightloss
 !Abdominal pain
-!Muscle weakness
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+weakness
 !Other history/
 findings
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 '''insufficiency'''
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 * Drugs- Chronic [[steroid]] therapy and its withdrawal, [[Opiates]]
 * [[Genetics|Genetic]]- Combined pituitary hormone deficiency (CPHD), [[POMC]] ([[Proopiomelanocortin]]) gene deficiency
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 |Normal
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 |'''Acute adrenal insufficiency'''
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 * Signs of shock
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 * Infection
 * Tumor
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