Celiac disease diagnostic criteria: Difference between revisions
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==Overview== | ==Overview== | ||
==Diagnostic criteria== | ==Diagnostic criteria== | ||
The diagnosis of celiac disease is made when at least four of the following five or three out of four (if the HLA genotype is not performed) diagnostic criteria are met | The diagnosis of celiac disease is made when at least four of the following five or three out of four (if the HLA genotype is not performed) diagnostic criteria are met:<ref name="pmid23609613">{{cite journal |vauthors=Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA |title=ACG clinical guidelines: diagnosis and management of celiac disease |journal=Am. J. Gastroenterol. |volume=108 |issue=5 |pages=656–76; quiz 677 |year=2013 |pmid=23609613 |pmc=3706994 |doi=10.1038/ajg.2013.79 |url=}}</ref> | ||
* Typical symptoms (Chronic diarrhea, chronic abdominal pain, malabsorption, bloating, constipation (more commonly in children), failure to thrive/weight loss, anorexia, vomiting, GERD) | * Typical symptoms (Chronic diarrhea, chronic abdominal pain, malabsorption, bloating, constipation (more commonly in children), failure to thrive/weight loss, anorexia, vomiting, GERD) | ||
* Serum positivity for Ig A autoantibodies at high titer | * Serum positivity for Ig A autoantibodies at high titer | ||
| Line 11: | Line 11: | ||
* Celiac enteropathy at the small intestinal biopsy | * Celiac enteropathy at the small intestinal biopsy | ||
* Response to gluten-free diet | * Response to gluten-free diet | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 14:01, 12 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]
Overview
Diagnostic criteria
The diagnosis of celiac disease is made when at least four of the following five or three out of four (if the HLA genotype is not performed) diagnostic criteria are met:[1]
- Typical symptoms (Chronic diarrhea, chronic abdominal pain, malabsorption, bloating, constipation (more commonly in children), failure to thrive/weight loss, anorexia, vomiting, GERD)
- Serum positivity for Ig A autoantibodies at high titer
- HLA-DQ2 or HLA-DQ8 genotypes
- Celiac enteropathy at the small intestinal biopsy
- Response to gluten-free diet
References
- ↑ Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA (2013). "ACG clinical guidelines: diagnosis and management of celiac disease". Am. J. Gastroenterol. 108 (5): 656–76, quiz 677. doi:10.1038/ajg.2013.79. PMC 3706994. PMID 23609613.