Blastomycosis differential diagnosis: Difference between revisions

Jump to navigation Jump to search
Line 7: Line 7:


====Fungal====
====Fungal====
* [[Coccidioidomycosis]]
* [[Coccidioidomycosis]]
* [[Histoplasmosis]]
* [[Histoplasmosis]]
Line 47: Line 45:
{| class="wikitable"
{| class="wikitable"
!Disease
!Disease
!Geophraphic distrubution
!Geographic distribution
!High risk Groups
!Differentiating Features
!Differentiating Features
!Culture findings
!Microscopic findings
!Differentiating Laboratory findings
!Differentiating Laboratory findings
|-
|-
|[[Histoplasmosis]]
|[[Histoplasmosis]]
|Mississippi and Ohio River valleys
|Mississippi and Ohio River valleys
|Palate and oral ulcers  spleenomegaly
|
|yeast are typically smaller, with narrow-based budding, found intracellularly within macrophages
* Cave dwellers
 
* Soil that contains bird or bat dropping
|
* Palate and oral ulcers   
* Spleenomegaly
|Yeast are typically smaller, with narrow-based budding, found intracellularly within macrophages
|Pancytopenia
|Pancytopenia
Urine antigen testing
Urine antigen testing
Line 62: Line 67:
|Southwestern US region
|Southwestern US region
|Opportunistic infection seen in AIDS
|Opportunistic infection seen in AIDS
|
* Rash on upper body or legs
* Night sweats
|Characteristic spherule appearance  
|Characteristic spherule appearance  
|Serologic tests( enzyme immune assay )more sensitive  
|Serologic tests( enzyme immune assay )more sensitive  
Line 67: Line 75:
|[[Paracoccidioidomycosis]]
|[[Paracoccidioidomycosis]]
|Central and South america
|Central and South america
|Lymphadenopathy,
|Opportunistic infection seen in AIDS
Hepatosplenomegaly,
|
 
* Lymphadenopathy
Bone marrow dysfunction
* Hepatosplenomegaly
* Bone marrow dysfunction  


|Smaller fungi with thin cell walls, forming  mariner wheel appearance,  circumferentially surrounding the parent cell.( Captain wheel appearance )
|Smaller fungi with thin cell walls, forming  mariner wheel appearance,  circumferentially surrounding the parent cell.( Captain wheel appearance )
Line 76: Line 85:
|-
|-
|[[Sporotrichosis]]
|[[Sporotrichosis]]
|Ubiquitous
|Gardeners
|
* Person’s hand or the arm
* Lymphadenitis (nodular)
|Finger or cigar shaped  yeast.
|Sporotrichin skin test
|-
|[[Aspergillosis]]
|Ubiquitous
|
|
|Gardeners are at high risk
* Cystic fibrosis or asthma. tuberculosis.
Lymphadenitis (nodular, and subacute to chronic)
 
* Immunocomprimised
|
|
|Biopsy of the skin confirms the diagnosis
* Wheezing
 
* Stuffiness, runny nose
* Hemoptysis
* Weight loss
|Septated hyphae with acute angle branching
|Cell wall detection using galactomannan antigen detection, Beta-D-glucan detection test.
|-
|-
|[[Tuberculosis|Pulmonary Tuberculosis]]
|[[Tuberculosis|Pulmonary Tuberculosis]]
|
|
|
|No cutaneous involvement
|No cutaneous involvement
|Acid fast bacteria
|Acid fast bacteria
|Sputum positive for 
|
|-
|-
|[[Nocardiosis]]
|[[Nocardiosis]]
|
|
|
|Immunocompromised people  
|Immunocompromised people  
Line 97: Line 125:
|}
|}


==References==
==iReferences==


{{Reflist|2}}
{{Reflist|2}}

Revision as of 19:32, 1 March 2017

Blastomycosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Blastomycosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Blastomycosis differential diagnosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Blastomycosis differential diagnosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Blastomycosis differential diagnosis

CDC on Blastomycosis differential diagnosis

Blastomycosis differential diagnosis in the news

Blogs on Blastomycosis differential diagnosis

Directions to Hospitals Treating Blastomycosis

Risk calculators and risk factors for Blastomycosis differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Vidit Bhargava, M.B.B.S [2] Aditya Ganti M.B.B.S. [3]

Overview

Acute pneumonia itself is a mild flu-like illness that needs to be differentiated from a number of other fungal/bacterial disorders. These disorders have overlapping signs & symptoms that often need detailed History, Physical examination and serological tests to pin-point the diagnosis. It can be often misinterpreted as community acquired pneumonia.

Fungal

Bacterial

Viral


Chronic and disseminated disease

Chronic blastomycosis may be initially confused with a malignancy or tuberculosis. While spread to other areas may be confused with malignancy as well. Skin lesions are often misdiagnosed as pyoderma gangreosum or keratoacanthoma. Therefore, a high index of suspicion is needed on the part of physician to diagnose blastomycosis

Disease Geographic distribution High risk Groups Differentiating Features Microscopic findings Differentiating Laboratory findings
Histoplasmosis Mississippi and Ohio River valleys
  • Cave dwellers
  • Soil that contains bird or bat dropping
  • Palate and oral ulcers
  • Spleenomegaly
Yeast are typically smaller, with narrow-based budding, found intracellularly within macrophages Pancytopenia

Urine antigen testing

Coccidioidomycosis Southwestern US region Opportunistic infection seen in AIDS
  • Rash on upper body or legs
  • Night sweats
Characteristic spherule appearance Serologic tests( enzyme immune assay )more sensitive
Paracoccidioidomycosis Central and South america Opportunistic infection seen in AIDS
  • Lymphadenopathy
  • Hepatosplenomegaly
  • Bone marrow dysfunction
Smaller fungi with thin cell walls, forming mariner wheel appearance, circumferentially surrounding the parent cell.( Captain wheel appearance )
Sporotrichosis Ubiquitous Gardeners
  • Person’s hand or the arm
  • Lymphadenitis (nodular)
Finger or cigar shaped yeast. Sporotrichin skin test
Aspergillosis Ubiquitous
  • Cystic fibrosis or asthma. tuberculosis.
  • Immunocomprimised
  • Wheezing
  • Stuffiness, runny nose
  • Hemoptysis
  • Weight loss
Septated hyphae with acute angle branching Cell wall detection using galactomannan antigen detection, Beta-D-glucan detection test.
Pulmonary Tuberculosis No cutaneous involvement Acid fast bacteria
Nocardiosis Immunocompromised people

worldwide distribution

Microscopic examination ; thin, branching gram-positive bacilli

acid fast positive

iReferences

Template:WH Template:WS