Acute retinal necrosis laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings associated with Acute retinal necrosis are those used to determine the [[viral]] pathogen, obtained from [[aqueous humor]] or the [[vitreous]].<ref name="pmid25356955">{{cite journal |vauthors=Brydak-Godowska J, Borkowski P, Szczepanik S, Moneta-Wielgoś J, Kęcik D |title=Clinical manifestation of self-limiting acute retinal necrosis |journal=Med. Sci. Monit. |volume=20 |issue= |pages=2088–96 |year=2014 |pmid=25356955 |pmc=4226315 |doi=10.12659/MSM.890469 |url=}}</ref> | |||
*Qualitative and Real-time [[Polymerase chain reaction]]<ref name="pmid25356955">{{cite journal |vauthors=Brydak-Godowska J, Borkowski P, Szczepanik S, Moneta-Wielgoś J, Kęcik D |title=Clinical manifestation of self-limiting acute retinal necrosis |journal=Med. Sci. Monit. |volume=20 |issue= |pages=2088–96 |year=2014 |pmid=25356955 |pmc=4226315 |doi=10.12659/MSM.890469 |url=}}</ref> | |||
**PCR-tests for Acute retinal necrosis patients will produce [[genomic]] evidence of the causative [[virus]]. | |||
**It is the preferred test due to the 90% specificity in detecting [[Herpes simplex virus]] (HSV), [[Varicella-zoster virus]] (VZV), and [[Cytomegalovirus]] (CMV). | |||
*Viral cultures may reveal positive results for HSV-1, HSV-2, VZV, or CMV.<ref name="pmid23052715">{{cite journal |vauthors=Silva RA, Berrocal AM, Moshfeghi DM, Blumenkranz MS, Sanislo S, Davis JL |title=Herpes simplex virus type 2 mediated acute retinal necrosis in a pediatric population: case series and review |journal=Graefes Arch. Clin. Exp. Ophthalmol. |volume=251 |issue=2 |pages=559–66 |year=2013 |pmid=23052715 |doi=10.1007/s00417-012-2164-8 |url=}}</ref> | |||
*[[Immunoflourescence]] may reveal [[antibodies]] indicative of Acute retinal necrosis pathogens.<ref name="pmid18159535">{{cite journal |vauthors=Singh A, Preiksaitis J, Ferenczy A, Romanowski B |title=The laboratory diagnosis of herpes simplex virus infections |journal=Can J Infect Dis Med Microbiol |volume=16 |issue=2 |pages=92–8 |year=2005 |pmid=18159535 |pmc=2095011 |doi= |url=}}</ref> | |||
*Detection of indicative [[antibodies]] via Goldmann-witmer coefficient.<ref name="pmid16458686">{{cite journal |vauthors=De Groot-Mijnes JD, Rothova A, Van Loon AM, Schuller M, Ten Dam-Van Loon NH, De Boer JH, Schuurman R, Weersink AJ |title=Polymerase chain reaction and Goldmann-Witmer coefficient analysis are complimentary for the diagnosis of infectious uveitis |journal=Am. J. Ophthalmol. |volume=141 |issue=2 |pages=313–8 |year=2006 |pmid=16458686 |doi=10.1016/j.ajo.2005.09.017 |url=}}</ref> | |||
==References== | ==References== |
Revision as of 17:12, 24 August 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.
Overview
Laboratory Findings
Laboratory findings associated with Acute retinal necrosis are those used to determine the viral pathogen, obtained from aqueous humor or the vitreous.[1]
- Qualitative and Real-time Polymerase chain reaction[1]
- PCR-tests for Acute retinal necrosis patients will produce genomic evidence of the causative virus.
- It is the preferred test due to the 90% specificity in detecting Herpes simplex virus (HSV), Varicella-zoster virus (VZV), and Cytomegalovirus (CMV).
- Viral cultures may reveal positive results for HSV-1, HSV-2, VZV, or CMV.[2]
- Immunoflourescence may reveal antibodies indicative of Acute retinal necrosis pathogens.[3]
- Detection of indicative antibodies via Goldmann-witmer coefficient.[4]
References
- ↑ 1.0 1.1 Brydak-Godowska J, Borkowski P, Szczepanik S, Moneta-Wielgoś J, Kęcik D (2014). "Clinical manifestation of self-limiting acute retinal necrosis". Med. Sci. Monit. 20: 2088–96. doi:10.12659/MSM.890469. PMC 4226315. PMID 25356955.
- ↑ Silva RA, Berrocal AM, Moshfeghi DM, Blumenkranz MS, Sanislo S, Davis JL (2013). "Herpes simplex virus type 2 mediated acute retinal necrosis in a pediatric population: case series and review". Graefes Arch. Clin. Exp. Ophthalmol. 251 (2): 559–66. doi:10.1007/s00417-012-2164-8. PMID 23052715.
- ↑ Singh A, Preiksaitis J, Ferenczy A, Romanowski B (2005). "The laboratory diagnosis of herpes simplex virus infections". Can J Infect Dis Med Microbiol. 16 (2): 92–8. PMC 2095011. PMID 18159535.
- ↑ De Groot-Mijnes JD, Rothova A, Van Loon AM, Schuller M, Ten Dam-Van Loon NH, De Boer JH, Schuurman R, Weersink AJ (2006). "Polymerase chain reaction and Goldmann-Witmer coefficient analysis are complimentary for the diagnosis of infectious uveitis". Am. J. Ophthalmol. 141 (2): 313–8. doi:10.1016/j.ajo.2005.09.017. PMID 16458686.