Paroxysmal nocturnal hemoglobinuria natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
==Natural History== | ==Natural History== | ||
==Complications== | ==Complications== | ||
An inconsistent, but potentially life-threatening, complication of PNH is the development of venous thrombosis (~40% of patients). These thrombi are often found in the [[hepatic vein|hepatic]] (causing [[Budd-Chiari syndrome]]; the most comon cause of mortality), [[Portal vein|portal]] (causing [[portal vein thrombosis]]), and cerebral veins (causing [[cerebral venous thrombosis]]). The risk of thrombosis has been directly linked to the size of the PNH clone. | An inconsistent, but potentially life-threatening, complication of PNH is the development of venous thrombosis (~40% of patients). These thrombi are often found in the [[hepatic vein|hepatic]] (causing [[Budd-Chiari syndrome]]; the most comon cause of mortality), [[Portal vein|portal]] (causing [[portal vein thrombosis]]), and cerebral veins (causing [[cerebral venous thrombosis]]). The risk of thrombosis has been directly linked to the size of the PNH clone. | ||
==Prognosis== | ==Prognosis== | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category: | [[Category:Rheumatology]] | ||
[[Category:Mature chapter]] | [[Category:Mature chapter]] | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Revision as of 13:17, 16 June 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Natural History
Complications
An inconsistent, but potentially life-threatening, complication of PNH is the development of venous thrombosis (~40% of patients). These thrombi are often found in the hepatic (causing Budd-Chiari syndrome; the most comon cause of mortality), portal (causing portal vein thrombosis), and cerebral veins (causing cerebral venous thrombosis). The risk of thrombosis has been directly linked to the size of the PNH clone.