Pleomorphic xanthoastrocytoma: Difference between revisions
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===Microscopic Pathology=== | ===Microscopic Pathology=== | ||
*On microscopic histopathological analysis, polymorphic xanthoastrocytoma is characterized by:<ref name="YanoSaigoh2013">{{cite journal|last1=Yano|first1=Hirohito|last2=Saigoh|first2=Chiemi|last3=Nakayama|first3=Noriyuki|last4=Hirose|first4=Yoshinobu|last5=Abe|first5=Masato|last6=Ohe|first6=Naoyuki|last7=Ozeki|first7=Michio|last8=Shinoda|first8=Jun|last9=Iwama|first9=Toru|title=Mixed neuronal-glial tumor in the temporal lobe of an infant: a case report|journal=Diagnostic Pathology|volume=8|issue=1|year=2013|pages=164|issn=1746-1596|doi=10.1186/1746-1596-8-164}}</ref> | *On microscopic histopathological analysis, polymorphic xanthoastrocytoma is characterized by:<ref name="YanoSaigoh2013">{{cite journal|last1=Yano|first1=Hirohito|last2=Saigoh|first2=Chiemi|last3=Nakayama|first3=Noriyuki|last4=Hirose|first4=Yoshinobu|last5=Abe|first5=Masato|last6=Ohe|first6=Naoyuki|last7=Ozeki|first7=Michio|last8=Shinoda|first8=Jun|last9=Iwama|first9=Toru|title=Mixed neuronal-glial tumor in the temporal lobe of an infant: a case report|journal=Diagnostic Pathology|volume=8|issue=1|year=2013|pages=164|issn=1746-1596|doi=10.1186/1746-1596-8-164}}</ref><ref name=grosspxa1>Pathology of pleomorphic xanthoastrocytoma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/pleomorphic-xanthoastrocytoma. Accessed on December 29, 2015</ref> | ||
:*Ill-defined margins | :*Ill-defined margins | ||
:*Spindle cells, polygonal cells, multi-nucleated cells, and lipid laden xanthomatous [[astrocytes]] | :*Spindle cells, polygonal cells, multi-nucleated cells, and lipid laden xanthomatous [[astrocytes]] | ||
Revision as of 16:53, 29 December 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Synonyms and keywords: Pleomorphic xanthoastrocytomas; PXA
Overview
Pleomorphic xanthoastrocytoma is a type of rare, low-grade astrocytoma (WHO Grade II) found in young patients who typically present with temporal lobe epilepsy.[1]
Pathophysiology
Gross Pathology
- On gross pathology, polymorphic xanthoastrocytoma is characterized by a well circumscribed mass, often with cystic component and involvement of the overlying leptomeninges.[2]
- Polymorphic xanthoastrocytomas are almost invariably (98%) located supratentorially, typically located superficially (peripherally), involving the cortex and overlying leptomeninges. Approximately half are located in the temporal lobe.
Microscopic Pathology
- Ill-defined margins
- Spindle cells, polygonal cells, multi-nucleated cells, and lipid laden xanthomatous astrocytes
- Pleomorphic nuclei
- No endothelial proliferation or necrosis
Immunohistochemistry
Differentiating Pleomorphic Xanthoastrocytoma from other Diseases
Pleomorphic xanthoastrocytoma must be differentiated from:[3][4]
- Desmoplastic infantile ganglioglioma
- Neuroblastoma
- Extraventricular neurocytoma
- Dysembryoplastic neuroepithelial tumor (DNET)
- Ganglioglioma
- Oligodendroglioma
References
- ↑ Pleomorphic xanthoastrocytoma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/pleomorphic-xanthoastrocytoma. Accessed on December 29, 2015
- ↑ 2.0 2.1 2.2 Pathology of pleomorphic xanthoastrocytoma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/pleomorphic-xanthoastrocytoma. Accessed on December 29, 2015
- ↑ 3.0 3.1 Yano, Hirohito; Saigoh, Chiemi; Nakayama, Noriyuki; Hirose, Yoshinobu; Abe, Masato; Ohe, Naoyuki; Ozeki, Michio; Shinoda, Jun; Iwama, Toru (2013). "Mixed neuronal-glial tumor in the temporal lobe of an infant: a case report". Diagnostic Pathology. 8 (1): 164. doi:10.1186/1746-1596-8-164. ISSN 1746-1596.
- ↑ Differential diagnosis of pleomorphic xanthoastrocytoma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/pleomorphic-xanthoastrocytoma. Accessed on December 29, 2015