Pineocytoma

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Pineocytoma, also known as a pinealocytoma, is a benign, slowly growing pineal parenchymal tumor.

Pathophysiology

• On gross pathology, pineocytoma is characterized by solid, sometimes with focal areas of cystic change, well-circumscribed mass with or without hemorrhage.
• On microscopic histopathological analysis, pineocytoma is characterized by:

• Cytologically benign cells (uniform size of nuclei, regular nuclear membrane, light chromatin)
• Pineocytomatous/neurocytic rosette, which is an irregular circular/flower-like arrangement of cells with a large meshwork of fibers (neuropil) at the centre

• According to the WHO classification of tumors of the central nervous system, pineocytoma is classified into a WHO grade I tumor.

Gallery

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  _{Intermediate magnification micrograph of a pineocytoma. HPS stain.}

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  _{High magnification micrograph of a pineocytoma. HPS stain.}

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  _{Very high magnification micrograph of a pineocytoma. HPS stain.}

Epidemiology

• Pineocytoma is a rare disease that tends to affect all the age groups, most commonly in the second decade of life.
• Pineocytoma affects men and women equally.

References

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