Gestational trophoblastic neoplasia natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
==Natural history== | ==Natural history== | ||
* Patient has early symptoms like [[vaginal bleeding]], | * Patient has early symptoms like [[vaginal bleeding]], passing of tissue resembling a “bunch of grapes” from the vagina, the abdomen may grow at a much faster rate than with a normal pregnancy | ||
* [[nausea]] and [[vomiting]], and absent fetal movement during pregnancy. | * [[nausea]] and [[vomiting]], and absent fetal movement during pregnancy. | ||
* As the tumor grows larger, patient may notice symptoms like | * As the tumor grows larger, patient may notice symptoms like lump in the vagina, [[hemoptysis]], [[chest pain]], trouble breathing, [[headache]], [[dizziness]], [[jaundice]], [[paralysis]], [[seizure]], [[dysarthria]], and [[dysphasia]]. | ||
==Prognosis== | ==Prognosis== |
Revision as of 20:32, 14 October 2015
Template:Choriocarcinoma Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Natural history
- Patient has early symptoms like vaginal bleeding, passing of tissue resembling a “bunch of grapes” from the vagina, the abdomen may grow at a much faster rate than with a normal pregnancy
- nausea and vomiting, and absent fetal movement during pregnancy.
- As the tumor grows larger, patient may notice symptoms like lump in the vagina, hemoptysis, chest pain, trouble breathing, headache, dizziness, jaundice, paralysis, seizure, dysarthria, and dysphasia.
Prognosis
- The prognosis for cure of patients with GTDs is good even when the disease has spread to distant organs, especially when only the lungs are involved.[1]
- The probability of cure depends on the following:
- Histologic type (invasive mole or choriocarcinoma)
- Extent of spread of the disease/largest tumor size
- Level of serum beta-hCG
- Duration of disease from the initial pregnancy event to start of treatment
- Number and specific sites of metastases
- Nature of antecedent pregnancy
- Extent of prior treatment
Complications
- Recurrance
- Anemia
References
- ↑ General Information About Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq Accessed on October 14, 2015