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| __NOTOC__ | | __NOTOC__ |
| {{Non-Hodgkin lymphoma}} | | {{Non-Hodgkin lymphoma}} |
| {{CMG}}; {{AE}} {{AS}}
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| ==Overview==
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| ==Pathophysiology==
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| ===B cell lymphomas===
| | Please help WikiDoc by adding more content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing. |
| {| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
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| ! Name
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| ! Size of cells
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| ! Site
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| ! Histomorphology
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| ! IHC
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| ! [[Translocations]] | |
| |-
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| | [[Follicular lymphoma]]
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| | small (centrocytes)
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| | lymph node, germinal center
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| | abundant atypical follicles (lack GC polarity, lack polar mantle zone), effaced sinuses, scattered large cells (centroblasts)
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| | CD10+, bcl-6+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
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| | t(14,18)
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| |-
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| | [[Mantle cell lymphoma]]
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| | small, monomorphic
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| | lymph node, mantle zone
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| | monomorphic lymphoid, abundant mitoses. +/-scattered epithelioid histiocytes, sclerosed blood vessels
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| | CD5+, CD23-, CD43+, cyclin D1+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
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| | t(11;14)(q13;q32)<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref>
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| |- | |
| | Extranodal marginal zone lymphoma (MALT lymphoma)
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| | small
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| | mucosa-associated lymphoid tissue, GI tract + elsewhere
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| | +/- lymphepithelial lesion (cluster of 3+ cells in epithelium)
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| | CD21+, CD11c+, CD5-, CD23-<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| |
| | ----------
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| |-
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| | Precursor B-cell lymphoblastic lymphoma/ leukemia
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| | small
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| | lymph node ???, bone marrow
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| | nuclei slightly large than resting lymphocytes, scant basophilic cytoplasm, irregular nuclear membrane, no nucleoli, stippled chromatin<ref name=Ref_PCPBoD8_315>{{Ref PCPBoD8|315}}</ref>
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| | CD10+, CD5-, TdT+, CD99+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
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| | +/-t(12;21)<ref name=Ref_PCPBoD8_317>{{Ref PCPBoD8|317}}</ref>
| |
| |-
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| | [[Hairy cell leukemia]]
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| | small
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| | bone marrow, peripheral blood
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| | perinuclear clearing, clear cytoplasm, central nucleus
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| | CD25+, CD103+, CD5-<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029]. Accessed on: 20 August 2010.</ref>
| |
| | ----------
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| |-
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| | [[Burkitt's lymphoma]]
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| | medium, monomorphic
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| | lymph node, germinal center (???)
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| | tingible-body macrophages ("starry sky" appearance), round nucleus, small nucleoli, mitoses +++
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| | CD10+, BCL6+, BCL2-
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| | t(8;14) (q24;q32)
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| |-
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| | [[Diffuse large B cell lymphoma]]
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| | large cells (>2x RBC, often larger), variable size
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| | lymph node usually, germinal center
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| | sheets of large discohesive cells; if only nodular = follicular lymphoma
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| | MIB1 >40%
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| | none / like follicular lymphoma t(14,18) / c-MYC (like Burkitt lymphoma)
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| |-
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| | [[Primary mediastinal B-cell lymphoma]]
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| | large (>2x RBC, often larger), variable size
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| | mediastinum
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| | ----------
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| | ----------
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| | ----------
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| |-
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| | B cell small lymphocytic lymphoma /<br>chronic lymphocytic leukemia
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| | small
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| | lymph node (???)
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| | proliferation centres
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| | CD5+, CD23+, CD43+, cyclin D1-
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| | trisomy 12; deletions of 11q, 13q, 17p<ref>{{Ref PCPBoD8|318}}</ref>
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| |- <!--
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| | Name
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| | size of cells ?
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| | site ?
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| | histomorphology ?
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| | IHC ?
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| | translocations ?
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| | clinical ?
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| | prevalence ?
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| | DDx ? -->
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| |}
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| ==References== | | ==References== |
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| {{Hematology}} | | {{Hematology}} |
| {{Hematological malignancy histology}} | | {{Hematological malignancy histology}} |
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| [[bn:অ-হজকিনের লসিকার্বুদ]]
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| [[de:Non-Hodgkin-Lymphom]]
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| [[es:Linfomas no-Hodgkins]]
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| [[fr:Lymphome non-hodgkinien]]
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| [[nl:Non-Hodgkin]]
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| [[ja:非ホジキンリンパ腫]]
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| [[pl:Chłoniaki nieziarnicze]]
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| [[pt:Linfoma não-Hodgkin]]
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| [[fi:Non-Hodgkinin lymfooma]]
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| [[sv: Non-Hodgkins lymfom]]
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| [[Category:Hematology]] | | [[Category:Hematology]] |