Sandbox ID Gastrointestinal and Intraabdominal

Anthrax, gastrointestinal

• Gastrointestinal anthrax

• Preferred regimen: Ciprofloxacin 400 mg intravenously every 8 h OR doxycycline 100 mg intravenously every 12 h combined with second agent: clindamycin 600 mg intravenously every 8 h or penicillin G 4 MU every 4–6 h OR meropenem 1 gm intravenously every 6–8 h or rifampin 300 mg every 12 h.
• Note:Treatment for 60 d is recommended to avoid relapse or breakthrough of incubating disease. If initial therapy is intravenous, then convert to oral administration (ciprofloxacin or doxycycline) when clinically indicated. Steroids may be considered as an adjunct therapy for patients with severe edema and for meningitis. For pregnant women, avoid doxycycline. Use ciprofloxacin and switch to oral penicillin once susceptibilities are known.

Infectious diarrhea

Immunocompetent

• Bacterial

• Shigella species:

• Preferred regimen:

• Adult dose: TMP-SMZ, 160 and 800 mg, respectively bid for 3 days (if susceptible ) OR fluoroquinolone (e.g., 300 mg ofloxacin, 400 mg norfloxacin, OR 500 mg Ciprofloxacin bid for 3 days)
• Pediatric dose:TMP-SMZ, 5 and 25 mg/kg, respectively bid for 3 days

• Preferred regimen:

• Adult dose: Nalidixic acid 1 g/d for 5 days OR Ceftriaxone; Azithromycin
• Pediatric dose: Nalidixic acid, 55 mg/kg/d for 5 days

• Non-typhi species of Salmonella

• Preferred regimen: Not recommended routinely, but if severe or patient is <6 monthes or >50 year old or has prostheses, valvular heart disease, severe atherosclerosis, malignancy, or uremia, TMP-SMZ (if susceptible) OR Fluoroquinolone, bid for 5 to 7 days; Ceftriaxone, 100 mg/kg/d in 1 or 2 divided doses

• Campylobacter species

• Preferred regimen:Erythromycin, 500 mg bid for 5 days

• Escherichia coli species

• Enterotoxigenic

• Preferred regimen: TMP-SMZ, 160 and 800 mg, respectively, bid for 3 days (if susceptible), OR Fluoroquinolone (e.g., 300 mg Ofloxacin, 400 mg Norfloxacin, or 500 mg ciprofloxacin bid for 3 days)

• Enteropathogenic

• Preferred regimen: TMP-SMZ, 160 and 800 mg, respectively, bid,for 3 days (if susceptible), OR Fluoroquinolone (e.g., 300 mg Ofloxacin, 400 mg Norfloxacin, or 500 mg ciprofloxacin bid for 3 days)

• Enteroinvasive

• Preferred regimen: TMP-SMZ, 160 and 800 mg, respectively, bid,for 3 days (if susceptible), OR Fluoroquinolone (e.g., 300 mg Ofloxacin, 400 mg Norfloxacin, or 500 mg Ciprofloxacin bid for 3 days)

• Enterohemorrhagic

• Preferred regimen: Avoid antimotility drugs; role of antibiotics unclear, and administration should be avoided.

• Aeromonas/Plesiomonas

• Preferred regimen: TMP-SMZ, 160 and 800 mg, respectively, bid for 3 days (if susceptible), Fluoroquinolone (e.g., 300 mg ofloxacin, 400 mg norfloxacin, or 500 mg Ciprofloxacin bid for 3 days)

• Yersinia species

• Preferred regimen: Antibiotics are not usually required; Deferoxamine therapy should be withheld; for severe infections or associated bacteremia treat as for immunocompromised hosts, using combination therapy with Doxycycline, Aminoglycoside, TMP-SMZ, OR Fluoroquinolone

• Vibrio cholerae O1 or O139

• Preferred regimen: Doxycycline, 300-mg single dose; or Tetracycline, 500 mg q.i.d. for 3 days; or TMP-SMZ, 160 and 800 mg, respectively, bid for 3 days; or single-dose Fluoroquinolone

• Toxigenic Clostridium difficile

• Preferred regimen: Offending antibiotic should be withdrawn if possible; Metronidazole, 250 mg q.i.d. to 500 mg t.i.d. for 3 to 10 days

• Parasites

• Giardia

• Preferred regimen:Metronidazole, 250-750 mg t.i.d. for 7-10 days

• Cryptosporidium species

• Preferred regimen: If severe, consider Paromomycin, 500 mg t.i.d. for 7 days

• Isospora species

• Preferred regimen: TMP-SMZ, 160 and 800 mg, respectively, bid for 7 to 10 days

• Cyclospora species

• Preferred regimen: TMP/SMZ, 160 and 800 mg, respectively, bid for 7 days

• Microsporidium species

• Preferred regimen: Not determined

• Entamoeba histolytica

• Preferred regimen: Metronidazole, 750 mg t.i.d. for 5 to 10 days, plus either Diiodohydroxyquin, 650 mg t.i.d. for 20 days, or Paromomycin, 500 mg tid for 7 days

Immunocompromised

• Bacterial

• Shigella species:

• Preferred regimen:

• Adult dose: TMP-SMZ, 160 and 800 mg, respectively b.i.d. for 7 to 10 days (if susceptible ) OR fluoroquinolone (e.g., 300 mg Ofloxacin, 400 mg Norfloxacin, OR 500 mg Ciprofloxacin b.i.d. for 7 to 10 days)
• Pediatric dose:TMP-SMZ, 5 and 25 mg/kg, respectively b.i.d. for 7 to 10 days

• Preferred regimen:

• Adult dose: Nalidixic acid 1 g/d for 7 to 10 days OR Ceftriaxone; Azithromycin
• Pediatric dose: Nalidixic acid, 55 mg/kg/d for 7 to 10 days

• Non-typhi species of Salmonella

• Preferred regimen: Not recommended routinely, but if severe or patient is <6 monthes or >50 year old or has prostheses, valvular heart disease, severe atherosclerosis, malignancy, or uremia, TMP-SMZ (if susceptible) OR Fluoroquinolone, b.i.d. for 14 days (or longer if relapsing); ceftriaxone, 100 mg/kg/d in 1 or 2 divided doses

• Campylobacter species

• Preferred regimen:Erythromycin, 500 mg b.i.d. for 5 days (may require prolonged treatment)

• Escherichia coli species

• Enterotoxigenic

• Preferred regimen: TMP-SMZ, 160 and 800 mg, respectively, b.i.d. for 3 days (if susceptible), OR Fluoroquinolone (e.g., 300 mg Ofloxacin, 400 mg Norfloxacin, or 500 mg Ciprofloxacin b.i.d. for 3 days) (Consider fluoroquinolone as for enterotoxigenic E. coli)

• Enteropathogenic

• Preferred regimen: TMP-SMZ, 160 and 800 mg, respectively, b.i.d.,for 3 days (if susceptible), OR Fluoroquinolone (e.g., 300 mg Ofloxacin, 400 mg Norfloxacin, or 500 mg Ciprofloxacin b.i.d. for 3 days)

• Enteroinvasive

• Preferred regimen: TMP-SMZ, 160 and 800 mg, respectively, b.i.d.,for 3 days (if susceptible), OR Fluoroquinolone (e.g., 300 mg ofloxacin, 400 mg Norfloxacin, or 500 mg Ciprofloxacin b.i.d. for 3 days)

• Enterohemorrhagic

• Preferred regimen: Avoid antimotility drugs; role of antibiotics unclear, and administration should be avoided.

• Aeromonas/Plesiomonas

• Preferred regimen: TMP-SMZ, 160 and 800 mg, respectively, b.i.d. for 3 days (if susceptible), Fluoroquinolone (e.g., 300 mg ofloxacin, 400 mg norfloxacin, or 500 mg Ciprofloxacin b.i.d. for 3 days)

• Yersinia species

• Preferred regimen: Doxycyclin, Aminoglycoside (in combination) or TMP-SMZ or Fluoroquinolone

• Vibrio cholerae O1 or O139

• Preferred regimen: Doxycycline, 300-mg single dose; or Tetracycline, 500 mg q.i.d. for 3 days; or TMP-SMZ, 160 and 800 mg, respectively, bid for 3 days; or single-dose Fluoroquinolone

• Toxigenic Clostridium difficile

• Preferred regimen: Offending antibiotic should be withdrawn if possible; Metronidazole, 250 mg q.i.d. to 500 mg t.i.d. for 3 to 10 days

• Parasites

• Giardia

• Preferred regimen:Metronidazole, 250-750 mg tid for 7-10 days

• Cryptosporidium species

• Preferred regimen: Paromomycin, 500 mg tid for 14 to 28 days, then bid if needed; highly active antiretroviral therapy including a protease inhibitor is warranted for patients with AIDS

• Isospora species

• Preferred regimen: TMP-SMZ, 160 and 800 mg, respectively, qid for 10 days, followed by TMP-SMZ thrice weekly, or weekly Sulfadoxine (500 mg) and Pyrimethamine (25 mg) indefinitely for patients with AIDS

• Cyclospora species

• Preferred regimen: TMP-SMZ, 160 and 800 mg, respectively, qid for 10 days, followed by TMP-SMZ thrice weekly indefinitely

• Microsporidium species

• Preferred regimen: Albendazole, 400 mg bid for 3 weeks; highly active antiretroviral therapy including a protease inhibitor is warranted for patients with AIDS

• Entamoeba histolytica

• Preferred regimen: Metronidazole, 750 mg tid for 5 to 10 days, plus either Diiodohydroxyquin, 650 mg t.i.d. for 20 days, or Paromomycin, 500 mg tid for 7 days