Multi-drug-resistant tuberculosis classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Classification

Based on the drug susceptibility testing of cinical isolates confirmed to be Mycobacterium tuberculosis, The strains are classified as follows.

Classification	Description
Monoresistance	Strain resistant to any one of the first line anti tubercular drugs
Polydrug resistance	Strain resistant to more than one first line anti tubercular drugs. (Other than both rifampicin and isoniazid)
Multidrug resistance	Strain resistant to both rifampicin and isoniazid
Extensive drug resistance	In addition to the multi drug resistance, strain is resistant to any fluroquinolone and to atleast one of the three second line anti injectable drugs like amikacin, capreomycin and kanamycin.
Rifampicin resistance	Using genotypic or phenotypic method, strain has been detected to have resistance to rifampicin with or without resistance to other anti TB drugs. It can include monoresistance, multi drug resistance, poly drug resistance or extensive drug resistance.

Clinical classification

Clinically drug resistant tuberculosis can be classified into acquired drug resistance and primary drug resistance according to pathophysiology.