NDN (gene): Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Necdin''' is a [[protein]] that in humans is encoded by the ''NDN'' [[gene]].<ref name="pmid9302265">{{cite journal | vauthors = MacDonald HR, Wevrick R | title = The necdin gene is deleted in [[Prader-Willi syndrome]] and is [[Imprinting (genetics)|imprinted]] in human and mouse | journal = Hum Mol Genet | volume = 6 | issue = 11 | pages = 1873–8 | date = January 1998 | pmid = 9302265 | pmc =  | doi = 10.1093/hmg/6.11.1873 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NDN necdin homolog (mouse)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4692| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Necdin homolog (mouse)
| HGNCid = 7675
| Symbol = NDN
| AltSymbols =; HsT16328
| OMIM = 602117
| ECnumber = 
| Homologene = 20559
| MGIid = 97290
| GeneAtlas_image1 = PBB_GE_NDN_209550_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043015 |text = gamma-tubulin binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005813 |text = centrosome}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007413 |text = axonal fasciculation}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0007585 |text = respiratory gaseous exchange}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0008347 |text = glial cell migration}} {{GNF_GO|id=GO:0019233 |text = sensory perception of pain}} {{GNF_GO|id=GO:0048011 |text = nerve growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0048666 |text = neuron development}} {{GNF_GO|id=GO:0048676 |text = axon extension involved in development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4692
    | Hs_Ensembl = ENSG00000182636
    | Hs_RefseqProtein = NP_002478
    | Hs_RefseqmRNA = NM_002487
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 21482492
    | Hs_GenLoc_end = 21483457
    | Hs_Uniprot = Q99608
    | Mm_EntrezGene = 17984
    | Mm_Ensembl = ENSMUSG00000033585
    | Mm_RefseqmRNA = NM_010882
    | Mm_RefseqProtein = NP_035012
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 62227270
    | Mm_GenLoc_end = 62228875
    | Mm_Uniprot = Q8C5K8
  }}
}}
'''Necdin homolog (mouse)''', also known as '''NDN''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NDN necdin homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4692| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This intronless gene is located in the [[Prader-Willi syndrome]] (PWS) deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mice suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This intronless gene is located in the Prader-Willi syndrome (PWS) deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.<ref name="entrez">{{cite web | title = Entrez Gene: NDN necdin homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4692| accessdate = }}</ref>
}}


==References==
Necdin is used to stimulate growth regulation and DNA-dependent transcription regulation.<ref>[http://www.uniprot.org/uniprot/Q99608 Uniprot]</ref>
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
NDN (gene) has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[E2F1]],<ref name = pmid9422723>{{cite journal | vauthors = Taniura H, Taniguchi N, Hara M, Yoshikawa K | title = Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1 | journal = J. Biol. Chem. | volume = 273 | issue = 2 | pages = 720–8 | date = January 1998 | pmid = 9422723 | doi =  10.1074/jbc.273.2.720}}</ref><ref name = pmid14593116>{{cite journal | vauthors = Kuwako K, Taniura H, Yoshikawa K | title = Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor | journal = J. Biol. Chem. | volume = 279 | issue = 3 | pages = 1703–12 | date = January 2004 | pmid = 14593116 | doi = 10.1074/jbc.M308454200 }}</ref>
* [[HNRNPU]],<ref name = pmid11813259>{{cite journal | vauthors = Taniura H, Yoshikawa K | title = Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix | journal = J. Cell. Biochem. | volume = 84 | issue = 3 | pages = 545–55 | pmid = 11813259 | doi =  10.1002/jcb.10047 | year=2002}}</ref>
* [[IL1A]],<ref name = pmid12913118>{{cite journal | vauthors = Hu B, Wang S, Zhang Y, Feghali CA, Dingman JR, Wright TM | title = A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 17 | pages = 10008–13 | date = August 2003 | pmid = 12913118 | pmc = 187743 | doi = 10.1073/pnas.1737765100 }}</ref>
* [[Low affinity nerve growth factor receptor]],<ref name = pmid14593116/><ref name = pmid12716928>{{cite journal | vauthors = Bronfman FC, Tcherpakov M, Jovin TM, Fainzilber M | title = Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome | journal = J. Neurosci. | volume = 23 | issue = 8 | pages = 3209–20 | date = April 2003 | pmid = 12716928 | doi =  }}</ref><ref name = pmid12414813>{{cite journal | vauthors = Tcherpakov M, Bronfman FC, Conticello SG, Vaskovsky A, Levy Z, Niinobe M, Yoshikawa K, Arenas E, Fainzilber M | title = The p75 neurotrophin receptor interacts with multiple MAGE proteins | journal = J. Biol. Chem. | volume = 277 | issue = 51 | pages = 49101–4 | date = December 2002 | pmid = 12414813 | doi = 10.1074/jbc.C200533200 }}</ref>
* [[NUCB2]],<ref name = pmid10915798>{{cite journal | vauthors = Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K | title = The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm | journal = J. Biol. Chem. | volume = 275 | issue = 41 | pages = 31674–81 | date = October 2000 | pmid = 10915798 | doi = 10.1074/jbc.M005103200 }}</ref>  and
* [[P53]]<ref name = pmid10347180>{{cite journal | vauthors = Taniura H, Matsumoto K, Yoshikawa K | title = Physical and functional interactions of neuronal growth suppressor necdin with p53 | journal = J. Biol. Chem. | volume = 274 | issue = 23 | pages = 16242–8 | date = June 1999 | pmid = 10347180 | doi =  10.1074/jbc.274.23.16242}}</ref>
{{Div col end}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Aizawa T, Maruyama K, Kondo H, Yoshikawa K | title = Expression of necdin, an embryonal carcinoma-derived nuclear protein, in developing mouse brain. | journal = Brain Res. Dev. Brain Res. | volume = 68 | issue = 2 | pages = 265–74 | year = 1992 | pmid = 1394972 | doi = 10.1016/0165-3806(92)90069-9 }}
| citations =
* {{cite journal | vauthors = Jay P, Rougeulle C, Massacrier A, Moncla A, Mattei MG, Malzac P, Roëckel N, Taviaux S, Lefranc JL, Cau P, Berta P, Lalande M, Muscatelli F | title = The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region. | journal = Nat. Genet. | volume = 17 | issue = 3 | pages = 357–61 | year = 1997 | pmid = 9354807 | doi = 10.1038/ng1197-357 }}
*{{cite journal | author=Aizawa T, Maruyama K, Kondo H, Yoshikawa K |title=Expression of necdin, an embryonal carcinoma-derived nuclear protein, in developing mouse brain. |journal=Brain Res. Dev. Brain Res. |volume=68 |issue= 2 |pages= 265-74 |year= 1992 |pmid= 1394972 |doi= }}
* {{cite journal | vauthors = Taniura H, Taniguchi N, Hara M, Yoshikawa K | title = Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1. | journal = J. Biol. Chem. | volume = 273 | issue = 2 | pages = 720–8 | year = 1998 | pmid = 9422723 | doi = 10.1074/jbc.273.2.720 }}
*{{cite journal | author=MacDonald HR, Wevrick R |title=The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse. |journal=Hum. Mol. Genet. |volume=6 |issue= 11 |pages= 1873-8 |year= 1998 |pmid= 9302265 |doi= }}
* {{cite journal | vauthors = Nakada Y, Taniura H, Uetsuki T, Inazawa J, Yoshikawa K | title = The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region. | journal = Gene | volume = 213 | issue = 1–2 | pages = 65–72 | year = 1998 | pmid = 9630521 | doi = 10.1016/S0378-1119(98)00206-6 }}
*{{cite journal | author=Jay P, Rougeulle C, Massacrier A, ''et al.'' |title=The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region. |journal=Nat. Genet. |volume=17 |issue= 3 |pages= 357-61 |year= 1997 |pmid= 9354807 |doi= 10.1038/ng1197-357 }}
* {{cite journal | vauthors = Taniura H, Matsumoto K, Yoshikawa K | title = Physical and functional interactions of neuronal growth suppressor necdin with p53 | journal = J. Biol. Chem. | volume = 274 | issue = 23 | pages = 16242–8 | year = 1999 | pmid = 10347180 | doi = 10.1074/jbc.274.23.16242 }}
*{{cite journal | author=Taniura H, Taniguchi N, Hara M, Yoshikawa K |title=Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1. |journal=J. Biol. Chem. |volume=273 |issue= 2 |pages= 720-8 |year= 1998 |pmid= 9422723 |doi= }}
* {{cite journal | vauthors = Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K | title = The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm | journal = J. Biol. Chem. | volume = 275 | issue = 41 | pages = 31674–81 | year = 2000 | pmid = 10915798 | doi = 10.1074/jbc.M005103200 }}
*{{cite journal | author=Nakada Y, Taniura H, Uetsuki T, ''et al.'' |title=The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region. |journal=Gene |volume=213 |issue= 1-2 |pages= 65-72 |year= 1998 |pmid= 9630521 |doi= }}
* {{cite journal | vauthors = Niinobe M, Koyama K, Yoshikawa K | title = Cellular and subcellular localization of necdin in fetal and adult mouse brain | journal = Dev. Neurosci. | volume = 22 | issue = 4 | pages = 310–9 | year = 2000 | pmid = 10965153 | doi = 10.1159/000017455 }}
*{{cite journal | author=Taniura H, Matsumoto K, Yoshikawa K |title=Physical and functional interactions of neuronal growth suppressor necdin with p53. |journal=J. Biol. Chem. |volume=274 |issue= 23 |pages= 16242-8 |year= 1999 |pmid= 10347180 |doi= }}
* {{cite journal | vauthors = Taniura H, Yoshikawa K | title = Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix | journal = J. Cell. Biochem. | volume = 84 | issue = 3 | pages = 545–55 | year = 2002 | pmid = 11813259 | doi = 10.1002/jcb.10047 }}
*{{cite journal | author=Taniguchi N, Taniura H, Niinobe M, ''et al.'' |title=The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 31674-81 |year= 2000 |pmid= 10915798 |doi= 10.1074/jbc.M005103200 }}
* {{cite journal | vauthors = Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K | title = A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1 | journal = J. Biol. Chem. | volume = 277 | issue = 25 | pages = 22541–6 | year = 2002 | pmid = 11959851 | doi = 10.1074/jbc.M109728200 }}
*{{cite journal | author=Niinobe M, Koyama K, Yoshikawa K |title=Cellular and subcellular localization of necdin in fetal and adult mouse brain. |journal=Dev. Neurosci. |volume=22 |issue= 4 |pages= 310-9 |year= 2000 |pmid= 10965153 |doi= }}
* {{cite journal | vauthors = Kobayashi M, Taniura H, Yoshikawa K | title = Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells | journal = J. Biol. Chem. | volume = 277 | issue = 44 | pages = 42128–35 | year = 2003 | pmid = 12198120 | doi = 10.1074/jbc.M205024200 }}
*{{cite journal | author=Taniura H, Yoshikawa K |title=Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix. |journal=J. Cell. Biochem. |volume=84 |issue= 3 |pages= 545-55 |year= 2002 |pmid= 11813259 |doi= }}
* {{cite journal | vauthors = Tcherpakov M, Bronfman FC, Conticello SG, Vaskovsky A, Levy Z, Niinobe M, Yoshikawa K, Arenas E, Fainzilber M | title = The p75 neurotrophin receptor interacts with multiple MAGE proteins | journal = J. Biol. Chem. | volume = 277 | issue = 51 | pages = 49101–4 | year = 2003 | pmid = 12414813 | doi = 10.1074/jbc.C200533200 }}
*{{cite journal | author=Sasaki A, Masuda Y, Iwai K, ''et al.'' |title=A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22541-6 |year= 2002 |pmid= 11959851 |doi= 10.1074/jbc.M109728200 }}
* {{cite journal | vauthors = Bronfman FC, Tcherpakov M, Jovin TM, Fainzilber M | title = Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome | journal = J. Neurosci. | volume = 23 | issue = 8 | pages = 3209–20 | year = 2003 | pmid = 12716928 | doi = }}
*{{cite journal | author=Kobayashi M, Taniura H, Yoshikawa K |title=Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells. |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 42128-35 |year= 2003 |pmid= 12198120 |doi= 10.1074/jbc.M205024200 }}
* {{cite journal | vauthors = Hu B, Wang S, Zhang Y, Feghali CA, Dingman JR, Wright TM | title = A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 17 | pages = 10008–13 | year = 2003 | pmid = 12913118 | pmc = 187743 | doi = 10.1073/pnas.1737765100 }}
*{{cite journal | author=Tcherpakov M, Bronfman FC, Conticello SG, ''et al.'' |title=The p75 neurotrophin receptor interacts with multiple MAGE proteins. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49101-4 |year= 2003 |pmid= 12414813 |doi= 10.1074/jbc.C200533200 }}
* {{cite journal | vauthors = Kuwako K, Taniura H, Yoshikawa K | title = Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor | journal = J. Biol. Chem. | volume = 279 | issue = 3 | pages = 1703–12 | year = 2004 | pmid = 14593116 | doi = 10.1074/jbc.M308454200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lau JC, Hanel ML, Wevrick R | title = Tissue-specific and imprinted epigenetic modifications of the human NDN gene | journal = Nucleic Acids Res. | volume = 32 | issue = 11 | pages = 3376–82 | year = 2004 | pmid = 15247330 | pmc = 443546 | doi = 10.1093/nar/gkh671 }}
*{{cite journal | author=Bronfman FC, Tcherpakov M, Jovin TM, Fainzilber M |title=Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome. |journal=J. Neurosci. |volume=23 |issue= 8 |pages= 3209-20 |year= 2003 |pmid= 12716928 |doi= }}
* {{cite journal | vauthors = Moon HE, Ahn MY, Park JA, Min KJ, Kwon YW, Kim KW | title = Negative regulation of hypoxia inducible factor-1alpha by necdin | journal = FEBS Lett. | volume = 579 | issue = 17 | pages = 3797–801 | year = 2005 | pmid = 15978586 | doi = 10.1016/j.febslet.2005.05.072 }}
*{{cite journal | author=Hu B, Wang S, Zhang Y, ''et al.'' |title=A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 17 |pages= 10008-13 |year= 2003 |pmid= 12913118 |doi= 10.1073/pnas.1737765100 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Kuwako K, Taniura H, Yoshikawa K |title=Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. |journal=J. Biol. Chem. |volume=279 |issue= 3 |pages= 1703-12 |year= 2004 |pmid= 14593116 |doi= 10.1074/jbc.M308454200 }}
*{{cite journal | author=Lau JC, Hanel ML, Wevrick R |title=Tissue-specific and imprinted epigenetic modifications of the human NDN gene. |journal=Nucleic Acids Res. |volume=32 |issue= 11 |pages= 3376-82 |year= 2004 |pmid= 15247330 |doi= 10.1093/nar/gkh671 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Moon HE, Ahn MY, Park JA, ''et al.'' |title=Negative regulation of hypoxia inducible factor-1alpha by necdin. |journal=FEBS Lett. |volume=579 |issue= 17 |pages= 3797-801 |year= 2005 |pmid= 15978586 |doi= 10.1016/j.febslet.2005.05.072 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Human proteins]]
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{{gene-15-stub}}

Revision as of 02:08, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Necdin is a protein that in humans is encoded by the NDN gene.[1][2]

Function

This intronless gene is located in the Prader-Willi syndrome (PWS) deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mice suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.[2]

Necdin is used to stimulate growth regulation and DNA-dependent transcription regulation.[3]

Interactions

NDN (gene) has been shown to interact with:

References

  1. ↑ MacDonald HR, Wevrick R (January 1998). "Prader-Willi syndrome and is imprinted". Hum Mol Genet. 6 (11): 1873–8. doi:10.1093/hmg/6.11.1873. PMID 9302265.
  2. ↑ 2.0 2.1 "Entrez Gene: NDN necdin homolog (mouse)".
  3. ↑ Uniprot
  4. ↑ Taniura H, Taniguchi N, Hara M, Yoshikawa K (January 1998). "Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1". J. Biol. Chem. 273 (2): 720–8. doi:10.1074/jbc.273.2.720. PMID 9422723.
  5. ↑ 5.0 5.1 Kuwako K, Taniura H, Yoshikawa K (January 2004). "Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor". J. Biol. Chem. 279 (3): 1703–12. doi:10.1074/jbc.M308454200. PMID 14593116.
  6. ↑ Taniura H, Yoshikawa K (2002). "Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix". J. Cell. Biochem. 84 (3): 545–55. doi:10.1002/jcb.10047. PMID 11813259.
  7. ↑ Hu B, Wang S, Zhang Y, Feghali CA, Dingman JR, Wright TM (August 2003). "A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 10008–13. doi:10.1073/pnas.1737765100. PMC 187743. PMID 12913118.
  8. ↑ Bronfman FC, Tcherpakov M, Jovin TM, Fainzilber M (April 2003). "Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome". J. Neurosci. 23 (8): 3209–20. PMID 12716928.
  9. ↑ Tcherpakov M, Bronfman FC, Conticello SG, Vaskovsky A, Levy Z, Niinobe M, Yoshikawa K, Arenas E, Fainzilber M (December 2002). "The p75 neurotrophin receptor interacts with multiple MAGE proteins". J. Biol. Chem. 277 (51): 49101–4. doi:10.1074/jbc.C200533200. PMID 12414813.
  10. ↑ Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K (October 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. 275 (41): 31674–81. doi:10.1074/jbc.M005103200. PMID 10915798.
  11. ↑ Taniura H, Matsumoto K, Yoshikawa K (June 1999). "Physical and functional interactions of neuronal growth suppressor necdin with p53". J. Biol. Chem. 274 (23): 16242–8. doi:10.1074/jbc.274.23.16242. PMID 10347180.

Further reading


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