Apolipoprotein C2: Difference between revisions

Jump to navigation Jump to search
Line 11: Line 11:
| summary_text = The protein encoded by this gene is secreted in plasma where it is a component of [[very low density lipoprotein]]s and [[chylomicron]]s. This protein activates the enzyme [[lipoprotein lipase]] in capillaries<ref name="pmid16314153">{{cite journal |author=Kim SY, Park SM, Lee ST |title=Apolipoprotein C-II is a novel substrate for matrix metalloproteinases |journal=Biochem. Biophys. Res. Commun. |volume=339 |issue=1 |pages=47–54 |year=2006 |pmid=16314153 |doi=10.1016/j.bbrc.2005.10.182}}</ref>, which hydrolyzes triglycerides and thus provides free [[fatty acid]]s for cells. Mutations in this gene cause [[Familial apoprotein CII deficiency|hyperlipoproteinemia type IB]], characterized by [[hypertriglyceridemia]], [[xanthoma]]s, and increased risk of [[pancreatitis]] and early [[atherosclerosis]].<ref name="entrez">{{cite web | title = Entrez Gene: APOC2 apolipoprotein C-II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=344| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is secreted in plasma where it is a component of [[very low density lipoprotein]]s and [[chylomicron]]s. This protein activates the enzyme [[lipoprotein lipase]] in capillaries<ref name="pmid16314153">{{cite journal |author=Kim SY, Park SM, Lee ST |title=Apolipoprotein C-II is a novel substrate for matrix metalloproteinases |journal=Biochem. Biophys. Res. Commun. |volume=339 |issue=1 |pages=47–54 |year=2006 |pmid=16314153 |doi=10.1016/j.bbrc.2005.10.182}}</ref>, which hydrolyzes triglycerides and thus provides free [[fatty acid]]s for cells. Mutations in this gene cause [[Familial apoprotein CII deficiency|hyperlipoproteinemia type IB]], characterized by [[hypertriglyceridemia]], [[xanthoma]]s, and increased risk of [[pancreatitis]] and early [[atherosclerosis]].<ref name="entrez">{{cite web | title = Entrez Gene: APOC2 apolipoprotein C-II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=344| accessdate = }}</ref>
}}
}}
== Related Chapters ==
* [[Apo C]]


==References==
==References==

Revision as of 16:06, 13 August 2012

WikiDoc Resources for Apolipoprotein C2

Articles

Most recent articles on Apolipoprotein C2

Most cited articles on Apolipoprotein C2

Review articles on Apolipoprotein C2

Articles on Apolipoprotein C2 in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Apolipoprotein C2

Images of Apolipoprotein C2

Photos of Apolipoprotein C2

Podcasts & MP3s on Apolipoprotein C2

Videos on Apolipoprotein C2

Evidence Based Medicine

Cochrane Collaboration on Apolipoprotein C2

Bandolier on Apolipoprotein C2

TRIP on Apolipoprotein C2

Clinical Trials

Ongoing Trials on Apolipoprotein C2 at Clinical Trials.gov

Trial results on Apolipoprotein C2

Clinical Trials on Apolipoprotein C2 at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Apolipoprotein C2

NICE Guidance on Apolipoprotein C2

NHS PRODIGY Guidance

FDA on Apolipoprotein C2

CDC on Apolipoprotein C2

Books

Books on Apolipoprotein C2

News

Apolipoprotein C2 in the news

Be alerted to news on Apolipoprotein C2

News trends on Apolipoprotein C2

Commentary

Blogs on Apolipoprotein C2

Definitions

Definitions of Apolipoprotein C2

Patient Resources / Community

Patient resources on Apolipoprotein C2

Discussion groups on Apolipoprotein C2

Patient Handouts on Apolipoprotein C2

Directions to Hospitals Treating Apolipoprotein C2

Risk calculators and risk factors for Apolipoprotein C2

Healthcare Provider Resources

Symptoms of Apolipoprotein C2

Causes & Risk Factors for Apolipoprotein C2

Diagnostic studies for Apolipoprotein C2

Treatment of Apolipoprotein C2

Continuing Medical Education (CME)

CME Programs on Apolipoprotein C2

International

Apolipoprotein C2 en Espanol

Apolipoprotein C2 en Francais

Business

Apolipoprotein C2 in the Marketplace

Patents on Apolipoprotein C2

Experimental / Informatics

List of terms related to Apolipoprotein C2

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Apolipoprotein C2 or Apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene.

The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries[1], which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.[2]

References

  1. Kim SY, Park SM, Lee ST (2006). "Apolipoprotein C-II is a novel substrate for matrix metalloproteinases". Biochem. Biophys. Res. Commun. 339 (1): 47–54. doi:10.1016/j.bbrc.2005.10.182. PMID 16314153.
  2. "Entrez Gene: APOC2 apolipoprotein C-II".

Template:WH Template:WS