Sandbox: wdx causes: Difference between revisions
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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/ | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/ | ||
sequestration/ | sequestration/ | ||
redistribution | redistribution | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt | ||
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! rowspan="9" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hematologic disorders | ! rowspan="9" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hematologic disorders | ||
! align="center" style="background:#DCDCDC;" |Myelodysplastic syndromes (MDS) | ! align="center" style="background:#DCDCDC;" |Myelodysplastic syndromes (MDS) | ||
| | | align="left" style="background:#F5F5F5;" | | ||
* Bone marrow infiltration | * Bone marrow infiltration | ||
* Ineffective hematopoiesis | * Ineffective hematopoiesis | ||
| align="center" style="background:#F5F5F5;" | | |||
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! align="left" style="background:#DCDCDC;" |Malignancies such as: | ! align="left" style="background:#DCDCDC;" |Malignancies such as: | ||
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* Multiple myeloma | * Multiple myeloma | ||
* Metastatic cancer | * Metastatic cancer | ||
| align=" | | align="left" style="background:#F5F5F5;" + | | ||
* Bone marrow infiltration | * Bone marrow infiltration | ||
* Ineffective hematopoiesis | * Ineffective hematopoiesis | ||
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! align="center" style="background:#DCDCDC;" |Myelofibrosis | ! align="center" style="background:#DCDCDC;" |Myelofibrosis | ||
| align=" | | align="left" style="background:#F5F5F5;" + | | ||
* Bone marrow infiltration | |||
| align="center" style="background:#F5F5F5;" + | + | | align="center" style="background:#F5F5F5;" + | + | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
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! align="center" style="background:#DCDCDC;" |Fanconi anemia | ! align="center" style="background:#DCDCDC;" |Fanconi anemia | ||
| align="center" style="background:#F5F5F5;" + | | |||
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|- | |- | ||
! align="center" style="background:#DCDCDC;" |Aplastic anemia | ! align="center" style="background:#DCDCDC;" |Aplastic anemia | ||
| align="center" style="background:#F5F5F5;" + |Immune destruction | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + |+ | |||
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|- | |- | ||
! align="center" style="background:#DCDCDC;" |Paroxysmal nocturnal hemoglobinuria | ! align="center" style="background:#DCDCDC;" |Paroxysmal nocturnal hemoglobinuria | ||
| align="center" style="background:#F5F5F5;" + |Immune destruction | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + |+ | |||
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|- | |- | ||
! align="center" style="background:#DCDCDC;" |Disseminated intravascular coagulation | ! align="center" style="background:#DCDCDC;" |Disseminated intravascular coagulation | ||
| align="center" style="background:#F5F5F5;" + |Consumption | |||
| align="center" style="background:#F5F5F5;" + | | |||
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|- | |- | ||
! align="center" style="background:#DCDCDC;" |Dyskeratosis congenital/telomere biology disorders | ! align="center" style="background:#DCDCDC;" |Dyskeratosis congenital/telomere biology disorders | ||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
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|- | |- | ||
! align="center" style="background:#DCDCDC;" |Shwachman-Diamond syndrome | ! align="center" style="background:#DCDCDC;" |Shwachman-Diamond syndrome | ||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + |+ | |||
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|- | |- | ||
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Immunology/ | ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Immunology/ | ||
Rheumatology | Rheumatology | ||
! align="center" style="background:#DCDCDC;" |SLE | ! align="center" style="background:#DCDCDC;" |SLE | ||
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! align="center" style="background:#DCDCDC;" |Felty syndrome | ! align="center" style="background:#DCDCDC;" |Felty syndrome | ||
| align="center" style="background:#F5F5F5;" + | | |||
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! align="center" style="background:#DCDCDC;" |Wiskott Aldrich syndrome | ! align="center" style="background:#DCDCDC;" |Wiskott Aldrich syndrome | ||
| align="center" style="background:#F5F5F5;" + | | |||
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|- | |- | ||
! align="center" style="background:#DCDCDC;" |GATA2 deficiency | ! align="center" style="background:#DCDCDC;" |GATA2 deficiency | ||
| align="center" style="background:#F5F5F5;" + | | |||
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! align="center" style="background:#DCDCDC;" |Hemophagocytic lymphohistiocytosis (HLH) | ! align="center" style="background:#DCDCDC;" |Hemophagocytic lymphohistiocytosis (HLH) | ||
| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |- | ||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |GI disorders | ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |GI disorders | ||
! align="center" style="background:#DCDCDC;" |Portal hypertension/cirrhosis | ! align="center" style="background:#DCDCDC;" |Portal hypertension/cirrhosis | ||
| align="left" style="background:#F5F5F5;" + | | |||
* Splenomegally | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |- | ||
! align="center" style="background:#DCDCDC;" |Storage diseases (eg, Gaucher) | ! align="center" style="background:#DCDCDC;" |Storage diseases (eg, Gaucher) | ||
| align="left" style="background:#F5F5F5;" + | | |||
* Splenomegaly | * Splenomegaly | ||
* Bone marrow infiltration | * Bone marrow infiltration | ||
| align="center" style="background:#F5F5F5;" + |+ | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + |+ | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |- | ||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Infections | ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Infections | ||
! align="center" style="background:#DCDCDC;" |Sepsis | ! align="center" style="background:#DCDCDC;" |Sepsis | ||
| align="left" style="background:#F5F5F5;" + | | |||
* Bone marrow infiltration | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |- | ||
! align="center" style="background:#DCDCDC;" |Viral infection such as HIV, hepatitis, Epstein-Barr virus | ! align="center" style="background:#DCDCDC;" |Viral infection such as HIV, hepatitis, Epstein-Barr virus | ||
| align="left" style="background:#F5F5F5;" + | | |||
* Marrow suppression | * Marrow suppression | ||
* Splenomegaly | * Splenomegaly | ||
| align="center" style="background:#F5F5F5;" + | | |||
| | | align="center" style="background:#F5F5F5;" + |+ | ||
| + | | align="center" style="background:#F5F5F5;" + |+ | ||
| + | | align="center" style="background:#F5F5F5;" + | | ||
| | | align="center" style="background:#F5F5F5;" + | | ||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |- | ||
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Nutritional | ! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Nutritional | ||
! align="center" style="background:#DCDCDC;" |Megaloblastic anemia | ! align="center" style="background:#DCDCDC;" |Megaloblastic anemia | ||
|Ineffective hematopoiesis | | align="left" style="background:#F5F5F5;" + | | ||
| | * Ineffective hematopoiesis | ||
| + | | align="center" style="background:#F5F5F5;" + | | ||
| align="center" style="background:#F5F5F5;" + |+ | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |- | ||
! align="center" style="background:#DCDCDC;" |Excessive alcohol | ! align="center" style="background:#DCDCDC;" |Excessive alcohol | ||
|Ineffective hematopoiesis | | align="left" style="background:#F5F5F5;" + | | ||
* Ineffective hematopoiesis | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |- | ||
! align="center" style="background:#DCDCDC;" |Other (eg, copper deficiency, zinc toxicity) | ! align="center" style="background:#DCDCDC;" |Other (eg, copper deficiency, zinc toxicity) | ||
|Ineffective hematopoiesis | | align="left" style="background:#F5F5F5;" + | | ||
* Ineffective hematopoiesis | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |- | ||
! align="center" style="background:#DCDCDC;" |Malnutrition | ! align="center" style="background:#DCDCDC;" |Malnutrition | ||
|Ineffective hematopoiesis | | align="left" style="background:#F5F5F5;" + | | ||
* Ineffective hematopoiesis | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
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| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + | | |||
|- | |- | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Medications | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Medications | ||
| Line 686: | Line 691: | ||
* Cytotoxic drugs | * Cytotoxic drugs | ||
* Idiosyncratic reactions to medications | * Idiosyncratic reactions to medications | ||
| align="left" style="background:#F5F5F5;" + | | |||
* Immune destruction | |||
| align="center" style="background:#F5F5F5;" + | | |||
| align="center" style="background:#F5F5F5;" + |+ | |||
| align="center" style="background:#F5F5F5;" + | | |||
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|- | |- | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category | ||
!Condition | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Decreased platelet production | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Decreased platelet production | ||
Revision as of 20:49, 4 September 2018
Differentiating Pancytopenia from Other Diseases
- Pancytopenia must be differentiated from a pseudo-syndromes like pseudo-thrombocytopenia, which is a laboratory artifact from platelet clumping.
- There are no other mimickers of pancytopenia, as the diagnosis can be unequivocally established by laboratory testing (complete blood count).
| Category | Condition | Etiology | Mechanism | Congenital | Acquried | Clinical manifestations | Para−clinical findings | Gold standard | Associated findings | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Demography | History | Symptoms | Signs | ||||||||||||||||||||||||
| Lab Findings | Imaging | ||||||||||||||||||||||||||
| Appearance | Fever | Bleeding | BP | Splenomegaly | Jaundice | Other | CBC | PBS | Bone marrow exam | PT | PTT | UA | |||||||||||||||
| Bone marrow infiltration | Bone marrow failure | Destruction/
sequestration/ redistribution |
Plt | HB | WBC | ||||||||||||||||||||||
| Hematologic disorders | Myelodysplastic syndromes (MDS) |
|
|||||||||||||||||||||||||
Malignancies such as:
|
|
+ | + | + | |||||||||||||||||||||||
| Myelofibrosis |
|
+ | |||||||||||||||||||||||||
| Fanconi anemia | + | ||||||||||||||||||||||||||
| Aplastic anemia | Immune destruction | + | |||||||||||||||||||||||||
| Paroxysmal nocturnal hemoglobinuria | Immune destruction | + | |||||||||||||||||||||||||
| Disseminated intravascular coagulation | Consumption | ||||||||||||||||||||||||||
| Dyskeratosis congenital/telomere biology disorders | |||||||||||||||||||||||||||
| Shwachman-Diamond syndrome | + | ||||||||||||||||||||||||||
| Immunology/
Rheumatology |
SLE | ||||||||||||||||||||||||||
| Felty syndrome | |||||||||||||||||||||||||||
| Wiskott Aldrich syndrome | + | ||||||||||||||||||||||||||
| GATA2 deficiency | + | ||||||||||||||||||||||||||
| Hemophagocytic lymphohistiocytosis (HLH) | + | ||||||||||||||||||||||||||
| GI disorders | Portal hypertension/cirrhosis |
|
|||||||||||||||||||||||||
| Storage diseases (eg, Gaucher) |
|
+ | + | ||||||||||||||||||||||||
| Infections | Sepsis |
|
|||||||||||||||||||||||||
| Viral infection such as HIV, hepatitis, Epstein-Barr virus |
|
+ | + | ||||||||||||||||||||||||
| Nutritional | Megaloblastic anemia |
|
+ | ||||||||||||||||||||||||
| Excessive alcohol |
|
||||||||||||||||||||||||||
| Other (eg, copper deficiency, zinc toxicity) |
|
||||||||||||||||||||||||||
| Malnutrition |
|
||||||||||||||||||||||||||
| Medications | Medications such as:
|
|
+ | ||||||||||||||||||||||||
| Category | Condition | Etiology | Decreased platelet production | Platelet destruction in blood | Platelet destruction in spleen | Congenital | Acquried | Demography | History | Appearance | Fever | Bleeding | BP | Splenomegaly | Jaundice | Other signs | Plt | HB | WBC | PBS | Bone marrow exam | PT | PTT | UA | Imaging | Gold standard | Associated findings |