Sandbox lung cancer differential: Difference between revisions
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* “Pop-corn” calcifications | * “Pop-corn” calcifications | ||
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* Benign tumor | |||
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| colspan="2" |Congenital peribronchial myofibroblastic tumor | | colspan="2" |Congenital peribronchial myofibroblastic tumor | ||
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* Rare | |||
* Sporadic | |||
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* Spindle cells | |||
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Revision as of 22:00, 6 March 2018
- Differentiation of primary and secondary lun tumors is difficult due to overlapping histologic features.
- Topography, size and form of pulmonary growth pattern are important aspects for the differential diagnosis.
- Primary lung tumors are mainly localized in upper lobes as singular nodules, metastases in lower lobes as multiple lesions.
- On the contarary, endobronchial primary or secondary squamous cell carcinomas findings of severe dysplasia and CIS of the bronchial epithelium are important.
- Stroma and vascularisation pattern of primary and secondary lung tumors differ in distribution, arrangement and extracellular matrix components.
- Pulmonary vascular changes in primary tumors are characterized by vascular infiltration, destruction and occlusion whereas in secondary tumors intravascular embolisation and extravasation predominate.
Malignant lung carcnimoma | |||||||||||
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Risk Factors | Pleuripotent cell | Topography | Histology | Gross | Immunohistochemistry | Imaging | Mets | Other differentiating features | |||
Squamous cell carcinoma | Papillary |
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Clear cell |
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Small cell |
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Basaloid |
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Small cell carcinoma | Combined small cell carcinoma |
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Adeno carcinoma | Adenocarcinoma, mixed sub type |
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Acinar adenocarcinoma | |||||||||||
Papillary adenocarcinoma |
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Bronchio-alveolar carcinoma | Non-mucinous | Consists of
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Mucinous |
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Mixed non-mucinous and mucinous or indeterminate | |||||||||||
Solid adenocarcinoma with mucin production | Fetal adenocarcinoma |
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Mucinous (“colloid”) carcinoma |
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Mucinous cystadenocarcinoma |
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Signet ring adenocarcinoma | |||||||||||
Clear cell adenocarcinoma | |||||||||||
Large cell carcinoma | Giant-cell carcinoma of the lung | ||||||||||
Basaloid large cell carcinoma of the lung | |||||||||||
Clear cell carcinoma of the lung | |||||||||||
Lymphoepithelioma-like carcinoma of the lung | |||||||||||
Large-cell lung carcinoma with rhabdoid phenotype | |||||||||||
Large cell neuroendocrine carcinoma of the lung | |||||||||||
Sarcomatoid carcinoma | Pleomorphic carcinoma | ||||||||||
Carcinosarcoma | |||||||||||
Spindle cell carcinoma | |||||||||||
Giant cell carcinoma | |||||||||||
Pulmonary blastoma | |||||||||||
Carcinoid tumour | Typical carcinoid | ||||||||||
Atypical carcinoid | |||||||||||
Salivary gland tumours | Mucoepidermoid carcinoma | ||||||||||
Adenoid cystic carcinoma | |||||||||||
Epithelial-myoepithelial carcinoma | |||||||||||
Preinvasive lesions | Squamous carcinoma in situ | ||||||||||
Atypical adenomatous hyperplasia | |||||||||||
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia | |||||||||||
Mesenchymal tumors | Epithelioid haemangioendothelioma / Angiosarcoma |
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Pleuropulmonary blastoma |
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Chondroma |
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Congenital peribronchial myofibroblastic tumor |
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Diffuse pulmonary lymphangiomatosis | |||||||||||
Inflammatory myofibroblastic tumor | |||||||||||
Synovial sarcoma
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Pulmonary artery sarcoma | |||||||||||
Pulmonary vein sarcoma |
Benign lung tumor | ||||||||
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Risk factors | Gross pathology | Histopathology | Immunohistochemistry | Topography | Prognosis | |||
Papilloma | Squamous cell papilloma | Exophytic and Inverted |
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N/A |
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Glandular papilloma | Not specific |
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N/A |
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Mixed squamous cell and glandular papilloma |
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N/A |
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Adenomas | Alveolar adenoma | |||||||
Papillary adenoma | ||||||||
Adenomas of the salivary gland type | Mucous gland adenoma | |||||||
Pleomorphic adenoma | ||||||||
Mucinous cystadenoma | ||||||||
Lymphoproliferative tumors | Marginal zone B-cell lymphoma of the MALT type | |||||||
Diffuse large B-cell lymphoma | ||||||||
Lymphomatoid granulomatosis | ||||||||
Langerhans cell histiocytosis | ||||||||
Miscellaneous tumors | Harmatoma | |||||||
Sclerosing hemangioma | ||||||||
Clear cell tumor | ||||||||
Germ cell tumors | Mature tratoma | |||||||
Immature teratoma | ||||||||
Other germ cell tumours | ||||||||
Intrapulmonary thymoma | ||||||||
Melanoma | ||||||||
Metastatic tumors |