This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene.
This gene encodes a member of the [[F-box protein]] family, members of which are characterized by an approximately 40 [[Structural motif|amino acid motif]], the F-box. The F-box proteins constitute one of the four subunits of [[Ubiquitin ligase|ubiquitin protein ligase complex]] called [[SCF complex|SCFs]] (SKP1-cullin-F-box), which function in [[phosphorylation]]-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing [[WD-40 domain|WD-40 domains]], Fbls containing [[Leucine-rich repeat|leucine-rich repeats]], and Fbxs containing either different [[Protein–protein interaction|protein-protein interaction]] modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple [[transcript variants]] encoding different [[isoforms]] have been found for this gene.
F-box protein 16 is a protein that in humans is encoded by the FBXO16 gene.[1]
Function
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene.
Cheng H, Ma Y, Ni X, Jiang M, Guo L, Jin W, Xu W, Cao G, Ji C, Yin K, Gu S, Ma Y, Xie Y, Mao Y (2002). "cDNA cloning and expression analysis of a novel human F-box only protein". Mol. Cells. 14 (1): 56–9. PMID12243353.
