Splenic marginal zone lymphoma laboratory findings: Difference between revisions

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{{Splenic marginal zone lymphoma}}
{{Splenic marginal zone lymphoma}}
{{CMG}}
 
{{CMG}}; {{AE}} {{AS}}
==Overview==
==Overview==
==Laboratory Findings==
Laboratory tests for splenic marginal zone lymphoma include [[complete blood count]] (CBC), blood chemistry studies, [[cytogenetic analysis]], [[flow cytometry]], [[immunohistochemistry]], [[genetic testing]], [[FISH]], [[PCR]], and [[immunophenotyping]].
Autoimmune thrombocytopenia and [[anemia]] sometimes seen in patients with SMZL. Circulating villous lymphocytes are sometimes observed in peripheral [[blood]] samples.<ref name="who1">[http://www.iarc.fr/WHO-BlueBooks/BBwebsite/bb3.html] Jaffe E.S., Harris N.L., Stein H., Vardiman J.W. (eds): '''World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Haemopoietic and Lymphoid Tissues.''' IARC Press: Lyon 2001 </ref> A [[monoclonal]] [[paraprotein]] is detected in a third of patients without [[hypergammaglobulinemia]] or hyperviscosity.<ref name="ber1">
==Laboratory tests==
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10706860&query_hl=7&itool=pubmed_ExternalLink]
Laboratory tests for splenic marginal zone lymphoma include:<ref name=”seer”>Splenic marginal zone lymphoma. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov/seertools/hemelymph/51f6cf57e3e27c3994bd5327/ Accessed on December 22</ref>
Berger F, Felman P, Thieblemont C, Pradier T, Baseggio L, Bryon PA, Salles G, Callet-Bauchu E, Coiffier B. "Non-MALT marginal zone B-cell lymphomas: a description of clinical presentation and outcome in 124 patients." '''Blood'''. 2000 Mar 15;95(6):1950-6. PMID: 10706860</ref><ref name="mol1"> [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=7573673&query_hl=9&itool=pubmed_ExternalLink]
* [[Complete blood count]] (CBC)
Mollejo M, Menarguez J, Lloret E, Sanchez A, Campo E, Algara P, Cristobal E, Sanchez E, Piris MA.
:* Thrombocytopenia
"Splenic marginal zone lymphoma: a distinctive type of low-grade B-cell lymphoma. A clinicopathological study of 13 cases." '''Am J Surg Pathol'''. 1995 Oct;19(10):1146-57.
:* Anaemia
PMID: 7573673</ref>
* Blood chemistry studies
* [[Cytogenetic analysis]]
* [[Flow cytometry]]
* Immunohistochemistry
* [[Genetic testing]]
* [[FISH]] (fluorescence in situ hybridization)
* [[PCR]]
* [[Immunophenotyping]]


==References==
==References==
{{reflist|2}}
{{Reflist|2}}
 
[[Category:Blood disorders]]
[[Category:Types of cancer]]
[[Category:Disease]]
[[Category :Hematology]]
{{WH}}
{{WH}}
{{WS}}
{{WS}}
[[Category:Disease]]

Revision as of 17:15, 22 December 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Laboratory tests for splenic marginal zone lymphoma include complete blood count (CBC), blood chemistry studies, cytogenetic analysis, flow cytometry, immunohistochemistry, genetic testing, FISH, PCR, and immunophenotyping.

Laboratory tests

Laboratory tests for splenic marginal zone lymphoma include:[1]

  • Thrombocytopenia
  • Anaemia

References

  1. ↑ Splenic marginal zone lymphoma. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov/seertools/hemelymph/51f6cf57e3e27c3994bd5327/ Accessed on December 22

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