Smallpox future or investigational therapies: Difference between revisions
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{{Smallpox}} | {{Smallpox}} | ||
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==Overview== | |||
Even though smallpox has been eradicated, there are undergoing studies to identify effective [[antiviral drug]]s against [[smallpox virus]] due to the potential of an [[outbreak]] as a result of [[bioterrorism]]. | |||
==Future or Investigational Therapies== | |||
Since the eradication of the [[smallpox virus]], several [[antiviral drugs]] have been studied combating orthopox [[viruses]] in general, including:<ref name="MooreSeward2006">{{cite journal|last1=Moore|first1=Zack S|last2=Seward|first2=Jane F|last3=Lane|first3=J Michael|title=Smallpox|journal=The Lancet|volume=367|issue=9508|year=2006|pages=425–435|issn=01406736|doi=10.1016/S0140-6736(06)68143-9}}</ref> | |||
* '''Cidofovir''' | |||
:* Inhibitor of the [[viral]] [[DNA polymerase]]<ref name="pmid12615302">{{cite journal| author=Smee DF, Sidwell RW| title=A review of compounds exhibiting anti-orthopoxvirus activity in animal models. | journal=Antiviral Res | year= 2003 | volume= 57 | issue= 1-2 | pages= 41-52 | pmid=12615302 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12615302 }} </ref> | |||
:* Treatment of other [[DNA viruses]] | |||
:* Investigational [[drug]] for the treatment of potential [[adverse effect]]s of [[smallpox]] [[vaccination]] | |||
:* Available in the [[IV]] form, with severe [[nephrotoxicity]] | |||
:* New formulations are being studied | |||
* '''Poxvirus protease inhibitors''' | |||
:* Currently being studied<ref name="pmid14972516">{{cite journal| author=Buller RM, Owens G, Schriewer J, Melman L, Beadle JR, Hostetler KY| title=Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model. | journal=Virology | year= 2004 | volume= 318 | issue= 2 | pages= 474-81 | pmid=14972516 | doi=10.1016/j.virol.2003.11.015 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14972516 }} </ref><ref name="pmid14742188">{{cite journal| author=Quenelle DC, Collins DJ, Wan WB, Beadle JR, Hostetler KY, Kern ER| title=Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir. | journal=Antimicrob Agents Chemother | year= 2004 | volume= 48 | issue= 2 | pages= 404-12 | pmid=14742188 | doi= | pmc=PMC321539 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14742188 }} </ref><ref name="pmid15283988">{{cite journal| author=Painter GR, Hostetler KY| title=Design and development of oral drugs for the prophylaxis and treatment of smallpox infection. | journal=Trends Biotechnol | year= 2004 | volume= 22 | issue= 8 | pages= 423-7 | pmid=15283988 | doi=10.1016/j.tibtech.2004.06.008 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15283988 }} </ref> | |||
* '''Compounds targeting host's intracellular pathways''' | |||
:* Currently being studied<ref name="pmid15690085">{{cite journal| author=Yang H, Kim SK, Kim M, Reche PA, Morehead TJ, Damon IK et al.| title=Antiviral chemotherapy facilitates control of poxvirus infections through inhibition of cellular signal transduction. | journal=J Clin Invest | year= 2005 | volume= 115 | issue= 2 | pages= 379-87 | pmid=15690085 | doi=10.1172/JCI23220 | pmc=PMC546427 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15690085 }} </ref> | |||
==References== | ==References== | ||
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[[Category:Needs content]] | [[Category:Needs content]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Pediatrics]] | [[Category:Pediatrics]] | ||
[[Category:Smallpox]] | [[Category:Smallpox]] | ||
Latest revision as of 19:04, 18 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Even though smallpox has been eradicated, there are undergoing studies to identify effective antiviral drugs against smallpox virus due to the potential of an outbreak as a result of bioterrorism.
Future or Investigational Therapies
Since the eradication of the smallpox virus, several antiviral drugs have been studied combating orthopox viruses in general, including:[1]
- Cidofovir
- Inhibitor of the viral DNA polymerase[2]
- Treatment of other DNA viruses
- Investigational drug for the treatment of potential adverse effects of smallpox vaccination
- Available in the IV form, with severe nephrotoxicity
- New formulations are being studied
- Poxvirus protease inhibitors
- Compounds targeting host's intracellular pathways
- Currently being studied[6]
References
- ↑ Moore, Zack S; Seward, Jane F; Lane, J Michael (2006). "Smallpox". The Lancet. 367 (9508): 425–435. doi:10.1016/S0140-6736(06)68143-9. ISSN 0140-6736.
- ↑ Smee DF, Sidwell RW (2003). "A review of compounds exhibiting anti-orthopoxvirus activity in animal models". Antiviral Res. 57 (1–2): 41–52. PMID 12615302.
- ↑ Buller RM, Owens G, Schriewer J, Melman L, Beadle JR, Hostetler KY (2004). "Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model". Virology. 318 (2): 474–81. doi:10.1016/j.virol.2003.11.015. PMID 14972516.
- ↑ Quenelle DC, Collins DJ, Wan WB, Beadle JR, Hostetler KY, Kern ER (2004). "Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir". Antimicrob Agents Chemother. 48 (2): 404–12. PMC 321539. PMID 14742188.
- ↑ Painter GR, Hostetler KY (2004). "Design and development of oral drugs for the prophylaxis and treatment of smallpox infection". Trends Biotechnol. 22 (8): 423–7. doi:10.1016/j.tibtech.2004.06.008. PMID 15283988.
- ↑ Yang H, Kim SK, Kim M, Reche PA, Morehead TJ, Damon IK; et al. (2005). "Antiviral chemotherapy facilitates control of poxvirus infections through inhibition of cellular signal transduction". J Clin Invest. 115 (2): 379–87. doi:10.1172/JCI23220. PMC 546427. PMID 15690085.