SNRPG: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Small nuclear ribonucleoprotein G''' is a [[protein]] that in humans is encoded by the ''SNRPG'' [[gene]].<ref name="pmid7744013">{{cite journal | vauthors = Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Lührmann R | title = snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions | journal = EMBO J. | volume = 14 | issue = 9 | pages = 2076–88  | date = June 1995 | pmid = 7744013 | pmc = 398308 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SNRPG small nuclear ribonucleoprotein polypeptide G| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6637| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Small nuclear ribonucleoprotein polypeptide G
| HGNCid = 11163
| Symbol = SNRPG
| AltSymbols =; MGC117317; SMG
| OMIM = 603542
| ECnumber = 
| Homologene = 37730
| MGIid = 1915261
| GeneAtlas_image1 = PBB_GE_SNRPG_205644_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0030532 |text = small nuclear ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0000245 |text = spliceosome assembly}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6637
    | Hs_Ensembl = ENSG00000143977
    | Hs_RefseqProtein = NP_003087
    | Hs_RefseqmRNA = NM_003096
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 70362012
    | Hs_GenLoc_end = 70374373
    | Hs_Uniprot = P62308
    | Mm_EntrezGene = 68011
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_026506
    | Mm_RefseqProtein = NP_080782
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Small nuclear ribonucleoprotein polypeptide G''', also known as '''SNRPG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SNRPG small nuclear ribonucleoprotein polypeptide G| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6637| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
SNRPG has been shown to [[Protein-protein interaction|interact]] with [[DDX20]]<ref name=pmid10601333>{{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G | title = Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1181–94 | date = December 1999 | pmid = 10601333 | pmc = 2168095 | doi = 10.1083/jcb.147.6.1181 }}</ref> and [[TACC1]].<ref name=pmid12165861>{{cite journal | vauthors = Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D | title = Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators | journal = Oncogene | volume = 21 | issue = 36 | pages = 5619–30  | date = August 2002 | pmid = 12165861 | doi = 10.1038/sj.onc.1205658 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Heinrichs V, Hackl W, Lührmann R | title = Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear RNA. Ultraviolet light cross-linking of protein G to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small nuclear ribonucleoprotein reconstituted in vitro | journal = J. Mol. Biol. | volume = 227 | issue = 1 | pages = 15–28 | year = 1992 | pmid = 1387914 | doi = 10.1016/0022-2836(92)90678-D }}
| citations =
* {{cite journal | vauthors = Plessel G, Lührmann R, Kastner B | title = Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core | journal = J. Mol. Biol. | volume = 265 | issue = 2 | pages = 87–94 | year = 1997 | pmid = 9020971 | doi = 10.1006/jmbi.1996.0713 }}
*{{cite journal | author=Heinrichs V, Hackl W, Lührmann R |title=Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear RNA. Ultraviolet light cross-linking of protein G to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small nuclear ribonucleoprotein reconstituted in vitro. |journal=J. Mol. Biol. |volume=227 |issue= 1 |pages= 15-28 |year= 1992 |pmid= 1387914 |doi= }}
* {{cite journal | vauthors = Fury MG, Zhang W, Christodoulopoulos I, Zieve GW | title = Multiple protein: protein interactions between the snRNP common core proteins | journal = Exp. Cell Res. | volume = 237 | issue = 1 | pages = 63–9 | year = 1997 | pmid = 9417867 | doi = 10.1006/excr.1997.3750 }}
*{{cite journal | author=Hermann H, Fabrizio P, Raker VA, ''et al.'' |title=snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. |journal=EMBO J. |volume=14 |issue= 9 |pages= 2076-88 |year= 1995 |pmid= 7744013 |doi= }}
* {{cite journal | vauthors = Bühler D, Raker V, Lührmann R, Fischer U | title = Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy | journal = Hum. Mol. Genet. | volume = 8 | issue = 13 | pages = 2351–7 | year = 1999 | pmid = 10556282 | doi = 10.1093/hmg/8.13.2351 }}
*{{cite journal | author=Plessel G, Lührmann R, Kastner B |title=Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core. |journal=J. Mol. Biol. |volume=265 |issue= 2 |pages= 87-94 |year= 1997 |pmid= 9020971 |doi= 10.1006/jmbi.1996.0713 }}
* {{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G | title = Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1181–94 | year = 1999 | pmid = 10601333 | pmc = 2168095 | doi = 10.1083/jcb.147.6.1181 }}
*{{cite journal | author=Fury MG, Zhang W, Christodoulopoulos I, Zieve GW |title=Multiple protein: protein interactions between the snRNP common core proteins. |journal=Exp. Cell Res. |volume=237 |issue= 1 |pages= 63-9 |year= 1998 |pmid= 9417867 |doi= 10.1006/excr.1997.3750 }}
* {{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G | title = Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli | journal = J. Cell Biol. | volume = 148 | issue = 6 | pages = 1177–86 | year = 2000 | pmid = 10725331 | pmc = 2174312 | doi = 10.1083/jcb.148.6.1177 }}
*{{cite journal | author=Bühler D, Raker V, Lührmann R, Fischer U |title=Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy. |journal=Hum. Mol. Genet. |volume=8 |issue= 13 |pages= 2351-7 |year= 2000 |pmid= 10556282 |doi= }}
* {{cite journal | vauthors = Urlaub H, Raker VA, Kostka S, Lührmann R | title = Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure | journal = EMBO J. | volume = 20 | issue = 1–2 | pages = 187–96 | year = 2001 | pmid = 11226169 | pmc = 140196 | doi = 10.1093/emboj/20.1.187 }}
*{{cite journal | author=Charroux B, Pellizzoni L, Perkinson RA, ''et al.'' |title=Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1181-94 |year= 2000 |pmid= 10601333 |doi= }}
* {{cite journal | vauthors = Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G | title = Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component | journal = J. Biol. Chem. | volume = 277 | issue = 9 | pages = 7540–5 | year = 2002 | pmid = 11748230 | doi = 10.1074/jbc.M110141200 }}
*{{cite journal | author=Charroux B, Pellizzoni L, Perkinson RA, ''et al.'' |title=Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. |journal=J. Cell Biol. |volume=148 |issue= 6 |pages= 1177-86 |year= 2000 |pmid= 10725331 |doi= }}
* {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = RNA | volume = 8 | issue = 4 | pages = 426–39 | year = 2002 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }}
*{{cite journal | author=Urlaub H, Raker VA, Kostka S, Lührmann R |title=Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure. |journal=EMBO J. |volume=20 |issue= 1-2 |pages= 187-96 |year= 2001 |pmid= 11226169 |doi= 10.1093/emboj/20.1.187 }}
* {{cite journal | vauthors = Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D | title = Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators | journal = Oncogene | volume = 21 | issue = 36 | pages = 5619–30 | year = 2002 | pmid = 12165861 | doi = 10.1038/sj.onc.1205658 }}
*{{cite journal | author=Pellizzoni L, Baccon J, Rappsilber J, ''et al.'' |title=Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7540-5 |year= 2002 |pmid= 11748230 |doi= 10.1074/jbc.M110141200 }}
* {{cite journal | vauthors = Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D | title = TACC1-chTOG-Aurora A protein complex in breast cancer | journal = Oncogene | volume = 22 | issue = 50 | pages = 8102–16 | year = 2003 | pmid = 14603251 | doi = 10.1038/sj.onc.1206972 }}
*{{cite journal | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi= }}
* {{cite journal | vauthors = Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R | title = The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome | journal = RNA | volume = 10 | issue = 6 | pages = 929–41 | year = 2004 | pmid = 15146077 | pmc = 1370585 | doi = 10.1261/rna.7320604 }}
*{{cite journal | author=Conte N, Charafe-Jauffret E, Delaval B, ''et al.'' |title=Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. |journal=Oncogene |volume=21 |issue= 36 |pages= 5619-30 |year= 2002 |pmid= 12165861 |doi= 10.1038/sj.onc.1205658 }}
* {{cite journal | vauthors = Ma Y, Dostie J, Dreyfuss G, Van Duyne GD | title = The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure | journal = Structure | volume = 13 | issue = 6 | pages = 883–92 | year = 2005 | pmid = 15939020 | doi = 10.1016/j.str.2005.03.014 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | year = 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Conte N, Delaval B, Ginestier C, ''et al.'' |title=TACC1-chTOG-Aurora A protein complex in breast cancer. |journal=Oncogene |volume=22 |issue= 50 |pages= 8102-16 |year= 2003 |pmid= 14603251 |doi= 10.1038/sj.onc.1206972 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Will CL, Schneider C, Hossbach M, ''et al.'' |title=The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. |journal=RNA |volume=10 |issue= 6 |pages= 929-41 |year= 2004 |pmid= 15146077 |doi= }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Ma Y, Dostie J, Dreyfuss G, Van Duyne GD |title=The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure. |journal=Structure |volume=13 |issue= 6 |pages= 883-92 |year= 2005 |pmid= 15939020 |doi= 10.1016/j.str.2005.03.014 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Ribonucleoproteins}}
{{WikiDoc Sources}}
 
 
{{gene-2-stub}}

Latest revision as of 13:54, 7 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Small nuclear ribonucleoprotein G is a protein that in humans is encoded by the SNRPG gene.[1][2]

Interactions

SNRPG has been shown to interact with DDX20[3] and TACC1.[4]

References

  1. ↑ Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Lührmann R (June 1995). "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". EMBO J. 14 (9): 2076–88. PMC 398308. PMID 7744013.
  2. ↑ "Entrez Gene: SNRPG small nuclear ribonucleoprotein polypeptide G".
  3. ↑ Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
  4. ↑ Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (August 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene. 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861.

Further reading


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