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{{Infobox_gene}}
{{PBB_Controls
'''Cbp/p300-interacting transactivator 2''' is a [[protein]] that in humans is encoded by the ''CITED2'' [[gene]].<ref name="pmid8901575">{{cite journal | vauthors = Shioda T, Fenner MH, Isselbacher KJ | title = msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 22 | pages = 12298–303 | date = Oct 1996 | pmid = 8901575 | pmc = 37985 | doi = 10.1073/pnas.93.22.12298 }}</ref><ref name="pmid10552932">{{cite journal | vauthors = Leung MK, Jones T, Michels CL, Livingston DM, Bhattacharya S | title = Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1 | journal = Genomics | volume = 61 | issue = 3 | pages = 307–13 | date = Nov 1999 | pmid = 10552932 | pmc = | doi = 10.1006/geno.1999.5970 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10370| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_CITED2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1r8u.
| PDB = {{PDB2|1r8u}}
| Name = Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
| HGNCid = 1987
| Symbol = CITED2
| AltSymbols =; MRG1; P35SRJ
| OMIM = 602937
| ECnumber = 
| Homologene = 4433
| MGIid = 1306784
| GeneAtlas_image1 = PBB_GE_CITED2_209357_at_tn.png
| GeneAtlas_image2 = PBB_GE_CITED2_207980_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001568 |text = blood vessel development}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007368 |text = determination of left/right symmetry}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0030325 |text = adrenal gland development}} {{GNF_GO|id=GO:0030511 |text = positive regulation of transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0045787 |text = positive regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10370
    | Hs_Ensembl = ENSG00000164442
    | Hs_RefseqProtein = NP_006070
    | Hs_RefseqmRNA = NM_006079
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 139735089
    | Hs_GenLoc_end = 139737478
    | Hs_Uniprot = Q99967
    | Mm_EntrezGene = 17684
    | Mm_Ensembl = ENSMUSG00000039910
    | Mm_RefseqmRNA = NM_010828
    | Mm_RefseqProtein = NP_034958
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 17412662
    | Mm_GenLoc_end = 17415072
    | Mm_Uniprot = Q6PGA9
  }}
}}
'''Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2''', also known as '''CITED2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10370| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
CITED2 has been shown to [[Protein-protein interaction|interact]] with [[EP300]],<ref name=pmid9887100>{{cite journal | vauthors = Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM | title = Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 | journal = Genes & Development | volume = 13 | issue = 1 | pages = 64–75 | date = Jan 1999 | pmid = 9887100 | pmc = 316375 | doi = 10.1101/gad.13.1.64 }}</ref><ref name=pmid12586840>{{cite journal | vauthors = Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S | title = Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 16021–9 | date = May 2003 | pmid = 12586840 | doi = 10.1074/jbc.M208144200 }}</ref><ref name=pmid11744733>{{cite journal | vauthors = Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S | title = Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 8559–65 | date = Mar 2002 | pmid = 11744733 | doi = 10.1074/jbc.M110850200 }}</ref><ref name=pmid10593900>{{cite journal | vauthors = Glenn DJ, Maurer RA | title = MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression | journal = The Journal of Biological Chemistry | volume = 274 | issue = 51 | pages = 36159–67 | date = Dec 1999 | pmid = 10593900 | doi = 10.1074/jbc.274.51.36159 }}</ref> [[LHX2]],<ref name=pmid10593900/> [[TFAP2A]],<ref name=pmid12586840/><ref name=pmid11744733/> and [[WT1]].<ref name=pmid17537799>{{cite journal | vauthors = Val P, Martinez-Barbera JP, Swain A | title = Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage | journal = Development | volume = 134 | issue = 12 | pages = 2349–58 | date = Jun 2007 | pmid = 17537799 | doi = 10.1242/dev.004390 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Haase M, Schott M, Bornstein SR, Malendowicz LK, Scherbaum WA, Willenberg HS | title = CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor | journal = The Journal of Endocrinology | volume = 192 | issue = 2 | pages = 459–65 | date = Feb 2007 | pmid = 17283246 | doi = 10.1677/JOE-06-0083 }}
| citations =
* {{cite journal | vauthors = Shioda T, Fenner MH, Isselbacher KJ | title = MSG1 and its related protein MRG1 share a transcription activating domain | journal = Gene | volume = 204 | issue = 1-2 | pages = 235–41 | date = Dec 1997 | pmid = 9434189 | doi = 10.1016/S0378-1119(97)00551-9 }}
*{{cite journal | author=Shioda T, Fenner MH, Isselbacher KJ |title=msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 22 |pages= 12298-303 |year= 1996 |pmid= 8901575 |doi= }}
* {{cite journal | vauthors = Sun HB, Zhu YX, Yin T, Sledge G, Yang YC | title = MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 23 | pages = 13555–60 | date = Nov 1998 | pmid = 9811838 | pmc = 24857 | doi = 10.1073/pnas.95.23.13555 }}
*{{cite journal | author=Shioda T, Fenner MH, Isselbacher KJ |title=MSG1 and its related protein MRG1 share a transcription activating domain. |journal=Gene |volume=204 |issue= 1-2 |pages= 235-41 |year= 1998 |pmid= 9434189 |doi= }}
* {{cite journal | vauthors = Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM | title = Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 | journal = Genes & Development | volume = 13 | issue = 1 | pages = 64–75 | date = Jan 1999 | pmid = 9887100 | pmc = 316375 | doi = 10.1101/gad.13.1.64 }}
*{{cite journal | author=Sun HB, Zhu YX, Yin T, ''et al.'' |title=MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 23 |pages= 13555-60 |year= 1998 |pmid= 9811838 |doi= }}
* {{cite journal | vauthors = Glenn DJ, Maurer RA | title = MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression | journal = The Journal of Biological Chemistry | volume = 274 | issue = 51 | pages = 36159–67 | date = Dec 1999 | pmid = 10593900 | doi = 10.1074/jbc.274.51.36159 }}
*{{cite journal | author=Bhattacharya S, Michels CL, Leung MK, ''et al.'' |title=Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. |journal=Genes Dev. |volume=13 |issue= 1 |pages= 64-75 |year= 1999 |pmid= 9887100 |doi= }}
* {{cite journal | vauthors = Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S | title = Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 8559–65 | date = Mar 2002 | pmid = 11744733 | doi = 10.1074/jbc.M110850200 }}
*{{cite journal  | author=Leung MK, Jones T, Michels CL, ''et al.'' |title=Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1. |journal=Genomics |volume=61 |issue= 3 |pages= 307-13 |year= 2000 |pmid= 10552932 |doi= 10.1006/geno.1999.5970 }}
* {{cite journal | vauthors = Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S | title = Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 16021–9 | date = May 2003 | pmid = 12586840 | doi = 10.1074/jbc.M208144200 }}
*{{cite journal | author=Glenn DJ, Maurer RA |title=MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36159-67 |year= 2000 |pmid= 10593900 |doi= }}
* {{cite journal | vauthors = Liu L, Amy V, Liu G, McKeehan WL | title = Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells | journal = In Vitro Cellular & Developmental Biology. Animal | volume = 38 | issue = 10 | pages = 582–94 | year = 2003 | pmid = 12762840 | pmc = 3225227 | doi = 10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2 }}
*{{cite journal | author=Bragança J, Swingler T, Marques FI, ''et al.'' |title=Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8559-65 |year= 2002 |pmid= 11744733 |doi= 10.1074/jbc.M110850200 }}
* {{cite journal | vauthors = Yokota H, Goldring MB, Sun HB | title = CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear | journal = The Journal of Biological Chemistry | volume = 278 | issue = 47 | pages = 47275–80 | date = Nov 2003 | pmid = 12960175 | doi = 10.1074/jbc.M304652200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Bhakat KK, Izumi T, Yang SH, Hazra TK, Mitra S | title = Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene | journal = The EMBO Journal | volume = 22 | issue = 23 | pages = 6299–309 | date = Dec 2003 | pmid = 14633989 | pmc = 291836 | doi = 10.1093/emboj/cdg595 }}
*{{cite journal  | author=Bragança J, Eloranta JJ, Bamforth SD, ''et al.'' |title=Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 16021-9 |year= 2003 |pmid= 12586840 |doi= 10.1074/jbc.M208144200 }}
* {{cite journal | vauthors = Tien ES, Davis JW, Vanden Heuvel JP | title = Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator | journal = The Journal of Biological Chemistry | volume = 279 | issue = 23 | pages = 24053–63 | date = Jun 2004 | pmid = 15051727 | doi = 10.1074/jbc.M401489200 }}
*{{cite journal | author=Liu L, Amy V, Liu G, McKeehan WL |title=Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells. |journal=In Vitro Cell. Dev. Biol. Anim. |volume=38 |issue= 10 |pages= 582-94 |year= 2003 |pmid= 12762840 |doi= }}
* {{cite journal | vauthors = Sperling S, Grimm CH, Dunkel I, Mebus S, Sperling HP, Ebner A, Galli R, Lehrach H, Fusch C, Berger F, Hammer S | title = Identification and functional analysis of CITED2 mutations in patients with congenital heart defects | journal = Human Mutation | volume = 26 | issue = 6 | pages = 575–82 | date = Dec 2005 | pmid = 16287139 | doi = 10.1002/humu.20262 }}
*{{cite journal | author=Yokota H, Goldring MB, Sun HB |title=CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 47275-80 |year= 2004 |pmid= 12960175 |doi= 10.1074/jbc.M304652200 }}
* {{cite journal | vauthors = Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS | title = Transcriptome analysis of human gastric cancer | journal = Mammalian Genome | volume = 16 | issue = 12 | pages = 942–54 | date = Dec 2005 | pmid = 16341674 | doi = 10.1007/s00335-005-0075-2 }}
*{{cite journal | author=Bhakat KK, Izumi T, Yang SH, ''et al.'' |title=Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene. |journal=EMBO J. |volume=22 |issue= 23 |pages= 6299-309 |year= 2004 |pmid= 14633989 |doi= 10.1093/emboj/cdg595 }}
* {{cite journal | vauthors = Chou YT, Yang YC | title = Post-transcriptional control of Cited2 by transforming growth factor beta. Regulation via Smads and Cited2 coding region | journal = The Journal of Biological Chemistry | volume = 281 | issue = 27 | pages = 18451–62 | date = Jul 2006 | pmid = 16675452 | doi = 10.1074/jbc.M601720200 }}
*{{cite journal | author=Tien ES, Davis JW, Vanden Heuvel JP |title=Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24053-63 |year= 2004 |pmid= 15051727 |doi= 10.1074/jbc.M401489200 }}
* {{cite journal | vauthors = Qu X, Lam E, Doughman YQ, Chen Y, Chou YT, Lam M, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC | title = Cited2, a coactivator of HNF4alpha, is essential for liver development | journal = The EMBO Journal | volume = 26 | issue = 21 | pages = 4445–56 | date = Oct 2007 | pmid = 17932483 | pmc = 2063472 | doi = 10.1038/sj.emboj.7601883 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Sperling S, Grimm CH, Dunkel I, ''et al.'' |title=Identification and functional analysis of CITED2 mutations in patients with congenital heart defects. |journal=Hum. Mutat. |volume=26 |issue= 6 |pages= 575-82 |year= 2006 |pmid= 16287139 |doi= 10.1002/humu.20262 }}
*{{cite journal | author=Oh JH, Yang JO, Hahn Y, ''et al.'' |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942-54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
*{{cite journal | author=Chou YT, Yang YC |title=Post-transcriptional control of Cited2 by transforming growth factor beta. Regulation via Smads and Cited2 coding region. |journal=J. Biol. Chem. |volume=281 |issue= 27 |pages= 18451-62 |year= 2006 |pmid= 16675452 |doi= 10.1074/jbc.M601720200 }}
*{{cite journal | author=Qu X, Lam E, Doughman YQ, ''et al.'' |title=Cited2, a coactivator of HNF4alpha, is essential for liver development. |journal=EMBO J. |volume=26 |issue= 21 |pages= 4445-56 |year= 2007 |pmid= 17932483 |doi= 10.1038/sj.emboj.7601883 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|CITED2}}
* {{UCSC gene details|CITED2}}
 
{{PDB Gallery|geneid=10370}}
 
 
{{gene-6-stub}}

Latest revision as of 02:18, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cbp/p300-interacting transactivator 2 is a protein that in humans is encoded by the CITED2 gene.[1][2][3]

Interactions

CITED2 has been shown to interact with EP300,[4][5][6][7] LHX2,[7] TFAP2A,[5][6] and WT1.[8]

References

  1. Shioda T, Fenner MH, Isselbacher KJ (Oct 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12298–303. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575.
  2. Leung MK, Jones T, Michels CL, Livingston DM, Bhattacharya S (Nov 1999). "Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1". Genomics. 61 (3): 307–13. doi:10.1006/geno.1999.5970. PMID 10552932.
  3. "Entrez Gene: CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2".
  4. Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM (Jan 1999). "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1". Genes & Development. 13 (1): 64–75. doi:10.1101/gad.13.1.64. PMC 316375. PMID 9887100.
  5. 5.0 5.1 Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S (May 2003). "Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2". The Journal of Biological Chemistry. 278 (18): 16021–9. doi:10.1074/jbc.M208144200. PMID 12586840.
  6. 6.0 6.1 Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S (Mar 2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". The Journal of Biological Chemistry. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
  7. 7.0 7.1 Glenn DJ, Maurer RA (Dec 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". The Journal of Biological Chemistry. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. PMID 10593900.
  8. Val P, Martinez-Barbera JP, Swain A (Jun 2007). "Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage". Development. 134 (12): 2349–58. doi:10.1242/dev.004390. PMID 17537799.

Further reading

External links