CEP350: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Centrosome-associated protein 350''' is a [[protein]] that in humans is encoded by the ''CEP350'' [[gene]].<ref name="pmid16314388">{{cite journal | vauthors = Yan X, Habedanck R, Nigg EA | title = A Complex of Two Centrosomal Proteins, CAP350 and FOP, Cooperates with EB1 in Microtubule Anchoring | journal = Mol Biol Cell | volume = 17 | issue = 2 | pages = 634–44 |date=Jan 2006 | pmid = 16314388 | pmc = 1356575 | doi = 10.1091/mbc.E05-08-0810 }}</ref><ref name="pmid15615782">{{cite journal | vauthors = Patel H, Truant R, Rachubinski RA, Capone JP | title = Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350 | journal = J Cell Sci | volume = 118 | issue = Pt 1 | pages = 175–86 |date=Dec 2004 | pmid = 15615782 | pmc = | doi = 10.1242/jcs.01600 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CEP350 centrosomal protein 350kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9857| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
CEP350 is a large protein with a CAP-Gly domain typically found in [[cytoskeleton]]-associated proteins. It primarily localizes to the [[centrosome]], a non-membraneous organelle that functions as the major [[microtubule-organizing center]] in [[animal]] cells. CEP350 is required to anchor [[microtubule]]s at the centrosome. Furthermore, it increases the stability of growing [[centriole]]s.<ref>{{cite journal|last=Le Clech|first=M|title=Role of CAP350 in centriolar tubule stability and centriole assembly.|journal=PLoS ONE|date=2008|volume=3|issue=12|pages=e3855|pmid=19052644|doi=10.1371/journal.pone.0003855|pmc=2586089}}</ref>
{{GNF_Protein_box
| image = PBB_Protein_CEP350_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2coz.
| PDB = {{PDB2|2coz}}
| Name = Centrosomal protein 350kDa
| HGNCid = 24238
| Symbol = CEP350
| AltSymbols =; CAP350; FLJ38282; FLJ44058; KIAA0480; gm133
| OMIM = 
| ECnumber = 
| Homologene = 8879
| MGIid = 1921331
| GeneAtlas_image1 = PBB_GE_CEP350_204373_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CEP350_213165_at_tn.png
| GeneAtlas_image3 = PBB_GE_CEP350_213956_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9857
    | Hs_Ensembl = ENSG00000135837
    | Hs_RefseqProtein = NP_055625
    | Hs_RefseqmRNA = NM_014810
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 178190496
    | Hs_GenLoc_end = 178350638
    | Hs_Uniprot = Q5VT06
    | Mm_EntrezGene = 74081
    | Mm_Ensembl = ENSMUSG00000033671
    | Mm_RefseqmRNA = XM_129509
    | Mm_RefseqProtein = XP_129509
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 157607184
    | Mm_GenLoc_end = 157686945
    | Mm_Uniprot = 
  }}
}}
'''Centrosomal protein 350kDa''', also known as '''CEP350''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CEP350 centrosomal protein 350kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9857| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: CEP350 centrosomal protein 350kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9857| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CEP350}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | vauthors=Yu W, Andersson B, Worley KC |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |display-authors=etal}}
*{{cite journal  | author=Seki N, Ohira M, Nagase T, ''et al.'' |title=Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=4 |issue= 5 |pages= 345-9 |year= 1998 |pmid= 9455484 |doi=  }}
*{{cite journal  | vauthors=Seki N, Ohira M, Nagase T |title=Characterization of cDNA clones in size-fractionated cDNA libraries from human brain |journal=DNA Res. |volume=4 |issue= 5 |pages= 345–9 |year= 1998 |pmid= 9455484 |doi=10.1093/dnares/4.5.345 |display-authors=etal}}
*{{cite journal  | author=Makalowska I, Sood R, Faruque MU, ''et al.'' |title=Identification of six novel genes by experimental validation of GeneMachine predicted genes. |journal=Gene |volume=284 |issue= 1-2 |pages= 203-13 |year= 2002 |pmid= 11891061 |doi=  }}
*{{cite journal  | vauthors=Makalowska I, Sood R, Faruque MU |title=Identification of six novel genes by experimental validation of GeneMachine predicted genes |journal=Gene |volume=284 |issue= 1–2 |pages= 203–13 |year= 2002 |pmid= 11891061 |doi=10.1016/S0378-1119(01)00897-6 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Andersen JS, Wilkinson CJ, Mayor T, ''et al.'' |title=Proteomic characterization of the human centrosome by protein correlation profiling. |journal=Nature |volume=426 |issue= 6966 |pages= 570-4 |year= 2003 |pmid= 14654843 |doi= 10.1038/nature02166 }}
*{{cite journal  | vauthors=Andersen JS, Wilkinson CJ, Mayor T |title=Proteomic characterization of the human centrosome by protein correlation profiling |journal=Nature |volume=426 |issue= 6966 |pages= 570–4 |year= 2003 |pmid= 14654843 |doi= 10.1038/nature02166 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Patel H, Truant R, Rachubinski RA, Capone JP |title=Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350. |journal=J. Cell. Sci. |volume=118 |issue= Pt 1 |pages= 175-86 |year= 2005 |pmid= 15615782 |doi= 10.1242/jcs.01600 }}
*{{cite journal  | vauthors=Oh JH, Yang JO, Hahn Y |title=Transcriptome analysis of human gastric cancer |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 |display-authors=etal}}
*{{cite journal  | author=Yan X, Habedanck R, Nigg EA |title=A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. |journal=Mol. Biol. Cell |volume=17 |issue= 2 |pages= 634-44 |year= 2006 |pmid= 16314388 |doi= 10.1091/mbc.E05-08-0810 }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Oh JH, Yang JO, Hahn Y, ''et al.'' |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942-54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
*{{cite journal  | vauthors=Nousiainen M, Silljé HH, Sauer G |title=Phosphoproteome analysis of the human mitotic spindle |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 |display-authors=etal}}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
*{{cite journal  | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal  | vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  | vauthors=Hoppeler-Lebel A, Celati C, Bellett G |title=Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex |journal=J. Cell Sci. |volume=120 |issue= Pt 18 |pages= 3299–308 |year= 2007 |pmid= 17878239 |doi= 10.1242/jcs.013102 |display-authors=etal}}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Hoppeler-Lebel A, Celati C, Bellett G, ''et al.'' |title=Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex. |journal=J. Cell. Sci. |volume=120 |issue= Pt 18 |pages= 3299-308 |year= 2007 |pmid= 17878239 |doi= 10.1242/jcs.013102 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=9857}}
{{Centrosome}}
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{{protein-stub}}
{{gene-1-stub}}
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Latest revision as of 19:33, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.[1][2][3]

CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. It primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles.[4]

It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.[3]

References

  1. ↑ Yan X, Habedanck R, Nigg EA (Jan 2006). "A Complex of Two Centrosomal Proteins, CAP350 and FOP, Cooperates with EB1 in Microtubule Anchoring". Mol Biol Cell. 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC 1356575. PMID 16314388.
  2. ↑ Patel H, Truant R, Rachubinski RA, Capone JP (Dec 2004). "Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350". J Cell Sci. 118 (Pt 1): 175–86. doi:10.1242/jcs.01600. PMID 15615782.
  3. ↑ 3.0 3.1 "Entrez Gene: CEP350 centrosomal protein 350kDa".
  4. ↑ Le Clech, M (2008). "Role of CAP350 in centriolar tubule stability and centriole assembly". PLoS ONE. 3 (12): e3855. doi:10.1371/journal.pone.0003855. PMC 2586089. PMID 19052644.

External links

Further reading



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