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| __NOTOC__
| | {{ACM}} |
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| {{CMG}}
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| {{SK}} Gammel's disease.
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| ==Overview==
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| ==Historical Perspective==
| | [[File:Captura de Pantalla 2024-05-18 a la(s) 9.33.11 p.m..png]] |
| * In 1925 Rothman wrote a comprehensive review on the subject of cutaneous manifestations in patients with malignant tumors and since then cases were added to proof for the relationship between internal neoplasm and some skin lesions.
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| * In 1953, the dermatologist, Dr. John A Gammel who was trained to link bizarre or recalcitrant dermatoses to internal diseases was the first one who described and labeled Erythema Granulatum Repens in a 55-year-old patient who had been complaining of pruritic scaly skin eruption and found few months later to have poorly differentiated adenocarcinoma <ref name="pmid25996397">{{cite journal| author=| title=Reorganized text. | journal=JAMA Otolaryngol Head Neck Surg | year= 2015 | volume= 141 | issue= 5 | pages= 428 | pmid=25996397 | doi=10.1001/jamaoto.2015.0540 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25996397 }} </ref>
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| * Up to 1992, there were only 49 cases in the literature, 41 of which (84%) were associated with a neoplasm.<ref name="pmidhttps://doi.org/https://doi.org/10.1016/0190-9622(">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=https://doi.org/https://doi.org/10.1016/0190-9622( | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref>
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| * EGR is associated with internal malignancy in 82% of cases. However, between 1990 and 2010, data was collected from the medical records of patients form dermatology department in University of Genoa and from databases as pubmed and medline, the conclusion of this literature review was that EGR is no longer considered as an obligate paraneoplastic syndrome. More than expected cases of EGR were found with no neoplasm association <ref name="pmidhttps://doi.org/10.1111/j.1468-3083.2012.04663.x">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=https://doi.org/10.1111/j.1468-3083.2012.04663.x | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref>
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| ==Classification==
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| * There is no established system for the classification of EGR. However, we can classify EGR as:
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| **Paraneoplastic EGR
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| **Non-paraneoplastic EGR could be: <ref name="pmidPMID: 30345340">{{cite journal| author=Richey PM, Fairley JA, Stone MS| title=Transformation from pityriasis rubra pilaris to erythema gyratum repens-like eruption without associated malignancy: A report of 2 cases. | journal=JAAD Case Rep | year= 2018 | volume= 4 | issue= 9 | pages= 944-946 | pmid=PMID: 30345340 | doi=10.1016/j.jdcr.2018.07.009 | pmc=6191946 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30345340 }} </ref>
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| *** Idiopathic EGR
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| *** EGR-like eruptions (different dermatologic lesions that mimic EGR)
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| *** EGR with concomittant skin disease as:
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| **** pityriasis rubra pilaris, psoriasis, ichthyosis, CREST, rheumatoid arthritis, tuberculosis, bullous pemphigoid, linear IgA disease, and hypereosinophilic syndrome
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| *** Drug-induced EGR examples are:
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| **** Azathioprine with type I autoimmune hepatitis
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| **** Interferon given for hepatitis C virus–related chronic hepatitis <ref name="pmidPMID: 30345340">{{cite journal| author=Richey PM, Fairley JA, Stone MS| title=Transformation from pityriasis rubra pilaris to erythema gyratum repens-like eruption without associated malignancy: A report of 2 cases. | journal=JAAD Case Rep | year= 2018 | volume= 4 | issue= 9 | pages= 944-946 | pmid=PMID: 30345340 | doi=10.1016/j.jdcr.2018.07.009 | pmc=6191946 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30345340 }} </ref>
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| ==Pathophysiology==
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| * The cause of EGR has not been identified.
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| * Many theories suggest that EGR is due to immunologic mechanisms. The immunologic mechanism theory is evidenced by the observed immunofluorescence patterns of IgG, C3, and C4 at the basement membrane: <ref name="pmidPMID: 22224159">{{cite journal| author=Gore M, Winters ME| title=Erythema gyratum repens: a rare paraneoplastic rash. | journal=West J Emerg Med | year= 2011 | volume= 12 | issue= 4 | pages= 556-8 | pmid=PMID: 22224159 | doi=10.5811/westjem.2010.11.2090 | pmc=3236141 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22224159 }} </ref>
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| ** Theory 1 the tumor induces antibodies that cross-react with the basement membrane of skin
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| ** Theory 2 the tumor produces polypeptides that bind skin antigens and render them immunogenic
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| ** Theory 3 deposition of tumor antigen-antibody complexes onto the basement membrane causes reactive dermatitis seen in EGR
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| <ref name="pmidPMID: 22224159">{{cite journal| author=Gore M, Winters ME| title=Erythema gyratum repens: a rare paraneoplastic rash. | journal=West J Emerg Med | year= 2011 | volume= 12 | issue= 4 | pages= 556-8 | pmid=PMID: 22224159 | doi=10.5811/westjem.2010.11.2090 | pmc=3236141 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22224159 }} </ref>
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| ==Causes==
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| * The cause of erythema gyratum repens has not been identified.
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| * Different theories suggest that EGR etiology is stemmed from an immunologic reaction.
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| *There is strong evidence of the association of EGR and systemic neoplasm proofed by the improvement of the skin lesions after the neoplasm treatment. However, that association doesn't mean causation.
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| ==Differentiating Erythema Gyratum Repens from Other Diseases==
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| *EGR has a narrow differential diagnosis. It has to be differentiated from Reactive gyrate erythematous eruptions, such as: <ref name="pmidPMID: 22224159">{{cite journal| author=Gore M, Winters ME| title=Erythema gyratum repens: a rare paraneoplastic rash. | journal=West J Emerg Med | year= 2011 | volume= 12 | issue= 4 | pages= 556-8 | pmid=PMID: 22224159 | doi=10.5811/westjem.2010.11.2090 | pmc=3236141 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22224159 }} </ref>
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| ** Reactive (figurate or gyrate) erythemas that are associated with malignancy include:
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| *** Erythema annulare centrifugum (EAC)
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| ***Necrolytic migratory erythema (NME)
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| ** Reactive (figurate or gyrate) erythemas that are not associated with malignancy include:
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| *** Erythema marginatum rheumaticum <ref name="pmidhttps://doi.org/10.1002/1097-0142(19880801)62:3<54">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=https://doi.org/10.1002/1097-0142(19880801)62:3<54 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref>
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| ***Erythema chronicum migrans
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| *** Familial annular erythema
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| *** The carrier state of chronic granulomatous disease
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| *** Subacute cutaneous lupus erythematosus
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| *** Neonatal lupus erythematosus
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| {| class="wikitable"
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| |+
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| ! colspan="4" |Reactive (figurate or gyrate) erythemas that are associated with malignancy
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| |-
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| !
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| !EGR
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| !EAC
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| !NME
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| |-
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| |Reactive erythema (figurate or Gyrate)
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| |Yes
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| |Yes
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| |Yes
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| |-
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| |Associated malignancy?
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| |More closely associated (84%)
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| Not obligatory paraneoplastic syndrome
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| |Only a minority of patients
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| |Can be the first presenting symptom
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| in 70% of patients with glucagonoma syndrome (2)
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| NME is the hallmark of gluconoma (3)
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| Obligatory paraneoplastic syndrome (2)
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| |-
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| |Commonly associated neoplasm
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| |Lung cancer
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| Esophageal cancer
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| Breast cancer
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| Metastatic cancer with an unknown origin
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| Cervical, stomach, and pharyngeal cancer (less common)
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| |No particular type of cancer appears to predominate
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| Mutinous ovarian carcinoma
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| Bronchial carcinoma
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| Myeloma
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| |Mainly pancreatic neuroendocrine tumors (PNETs) (glucagonoma)
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| |-
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| |Other association
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| |Tuberculosis
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| CREST syndrome (calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia).
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| |Infections
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| Allergic reactions to drugs
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| |No other association but it can be misdiagnosed as contact dermatitis or intertrigo, inverse psoriasis, zinc deficiency, and other nutritional deficiencies
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| |-
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| |Skin lesion description
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| |Migratory annular and configurate erythematous bands
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| that form concentric rings
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| Wood grain scaly appearance
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| scale follows the leading edge of the bands
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| Eruption migrates more rapidly, 1cm/d
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| Cover the trunk and proximal extremities, sparing the hands, feet, and face. Can eventually involve the face
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|
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| |Migratory annular and configurate erythematous
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| or polycyclic lesions
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| Urticarial in appearance," ringed, arcuate figures"
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| Eruption migrate at a slower rate (2 -3 mm/d) reaching up to 10 cm in diameter with central clearing.
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| Cover only a small percentage of the total body surface
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| |migratory circinate erythema/plaques with areas of necrosis and sloughing (3)
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| Crusted Erythematous scaly plaques with centrifugal growth
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| Spontaneous exacerbation and remission periods without knowing what the trigger is
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| Perineum, distal extremities, lower abdomen, and face are the most commonly affected sites.
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|
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| |-
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| |First named/described by
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| |Gammel in 1952
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| |Darier 1916<br />
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| |Becker et al. in 1942 was the first to describe the association
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| Wilkinson in 1973 was the first who named it.
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| |-
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| |Incidence
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| |Very rare
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| |Uncommon but not rare
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| |Rare paraneoplastic dermatosis
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| Studies in the US showed only 2,705 cases of pancreatic neuroendocrine tumors in a period of 28 years, with glucagonomas in only 1.3% of these neoplasms
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| Combined with glucagonoma syndrome, has an estimated global incidence of 1 case per 20 million people (3)
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| |-
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| |Demographics
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| |Caucasian
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| Male: female ratio is 2: 1
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| Average age was 62 years.
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| |No tendency for EAC to favor any age, race, or sex.
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| |-
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| |Subgroups
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| |Deep: Firm border, rarely pruritic, no scales
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| Superficial: indistinct scaly border , usually pruritic,
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| |-
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| |Histopathology
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| |Nonspecific
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| moderate perivascular lymphohistiocytic infiltrate
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| Mild focal spongiosis
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| parakeratosis
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| Eosinophils and melanophages have also been reported in the dermal infiltrate
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| |Deep form:
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| Mononuclear, perivascular infiltrate in the middle and lower portions of the dermis (coat sleeve-like configuration)
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| Infiltrate is primarily of lymphocytes, but eosinophils are occasionally present
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| Extravasation of erythrocytes is associated with endothelial swelling
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| No epidermal changes
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| Superficial:
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| more non-specific
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| slight superficial perivascular lymphohistiocytic infiltrate
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| Focal parakeratosis and mild spongiosis with microvesiculation
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| |Paleness and spongiosis of the upper layer of the epidermis.
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| A perivascular lymphocytic and histiocytic infiltrate
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| Necrotic keratinocytes are common and can lead to erosions, crusting and scaling
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| |-
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| |Pathogenesis
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| |Not fully known but theories relate it to immunologic mechanisms.
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| |Not fully clarified but attributed to zinc deficiency and hypoaminoacedemia as Increased glucagon increases gluconeogesis.
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| Although NME can be the first symptom of glucagonoma, high glucagon levels cant explain the skin manifestations.
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| |-
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| |Clinical manifestation/symptoms
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| |Skin lesions, weight loss, fatigue, fever, and anorexia
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| |Weight loss, anemia, diabetes, diarrhea, and stomatitis.
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| |-
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| |Lab finding
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| No specific laboratory changes
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| Eosinophilia has been reported
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| Decreased T lymphocytes and increased B lymphocytes
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| were observed in an EGR patient with increased luteinizing hormone and follicle-stimulating hormone as well as decreased serum levels of C3
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| Normal percentages of B and T lymphocytes and normal T-cell function were reported in an EGR patient without cancer.
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| No specific laboratory changes
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| Eosinophilia of the peripheral blood, as well as tissue, can be observed in EAC associated with a drug reaction or parasitic infection
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| Decreased T lymphocytes and increased B lymphocytes
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| |increased glucagon level (3)
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| <br />
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| |-
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| |Other evaluation
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| |Extensive evaluation for possible cancer
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| CBC,CMP, imaging as CT chest or abdomen
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| EGR patients with underlying malignancies had cancers associated with tobacco abuse.
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| |Evaluation for possible infection or drug reaction (prescribed and non-prescribed)
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| complete blood count, urinalysis, and routine serum liver and kidney function tests.
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| |Evaluation of the associated tumor:
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| CT or MRI abdomen
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| Selective visceral angiography to localize the tumor
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| Positron Emission tomography (PET)
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| Octreotide scintigraphy
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| |Treatment
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| Identification and treatment of the underlying condition (eg. resection of the tumor)
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| |Identification and treatment of the underlying condition (eg. resection of the tumor)
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| |Identification and treatment of the underlying condition (eg. resection of the tumor)
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| |-
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| |Symptomatic therapy as antihistamine and corticosteroids (Not very effective)
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| |Systemic corticosteroids for the deep form and topical corticosteroids for the superficial form
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| Lesions of EAC, however, frequently recur following discontinuation of such treatment
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| |Prognosis
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| |Skin manifestations can be improved within 48 hours of the resection of the underlying tumor
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| The improvement sometimes can temporary with recurrence of the skin lesions specially in cases of metastasis
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| Death can occur any time dending on the type and location of tumoe rnd the timingg f its discovery
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| |Lesions disaapears after the underlying etiology is managed (allergy, infection, malignancy)
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| if no underlying cause, lesions can recur after discontinuation of the supportive treatment.
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| |Due to the difficulty of NME recognition, and its association with glucagonoma, diagnosis is usually delayed(3)
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| NME usually resolved after the resection and treatment of the pancreatic tumor, eg 10 days after tumor resection
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| Early recognition is crucial for better diagnosis<br />
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| |}
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| ==Epidemiology and Demographics==
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| * EGR is a rare dermatologic disease, usually associated with paraneoplastic neoplasm
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| '''Age'''
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| * The average age of onset of EGR is in the seventh decade of life (65 years old)
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| '''Gender'''
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| * The male to female ratio is 2:1
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| '''Race'''
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| * EGR commonly affects Caucasians
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| ==Risk Factors==
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| * There are no established risk factors for EGR
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| ==Screening==
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| * There are no screening tests for EGR.
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| * Screening for internal malignancy should be done immediately after EGR is diagnosed.
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| ==Natural History, Complications, and Prognosis==
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| * The majority of patients with EGR presents with severely pruritic erythematous skin lesions that appear several months prior to the malignancy diagnosis <ref name="pmidPMID: 22224159">{{cite journal| author=Gore M, Winters ME| title=Erythema gyratum repens: a rare paraneoplastic rash. | journal=West J Emerg Med | year= 2011 | volume= 12 | issue= 4 | pages= 556-8 | pmid=PMID: 22224159 | doi=10.5811/westjem.2010.11.2090 | pmc=3236141 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22224159 }} </ref>
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| * If the underlying malignancy left untreated, the debilitating pruritus could persist until the patient dies <ref name="pmidPMID: 22224159">{{cite journal| author=Gore M, Winters ME| title=Erythema gyratum repens: a rare paraneoplastic rash. | journal=West J Emerg Med | year= 2011 | volume= 12 | issue= 4 | pages= 556-8 | pmid=PMID: 22224159 | doi=10.5811/westjem.2010.11.2090 | pmc=3236141 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22224159 }} </ref>
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| *Prognosis depends on the type of the underlying tumor and the probability of its treatment. It depends on the time of the EGR onset and the neoplasm discovery. The course and prognosis of EGR can be one of the following:
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| ** Complete cure of the skin eruption and pruritus after removal and treatment of the internal neoplasm
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| ** Temporary improvement then recurrence of the eruption (specially in cases of metastasis)
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| ** No effect of the tumor treatment on the course of EGR
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| ** Death can occur few weeks after the discovery of the malignancy, few months, or four years as in Gammel's patient.
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| ==Diagnosis==
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| ===Diagnostic Study of Choice===
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| * EGR is mainly diagnosed clinically by its characteristic skin lesions.
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| * It is considered as a cutaneous marker of malignancy with high specificity so physicians shouldn't miss its unique clinical skin presentation.
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| ===History and Symptoms===
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| * The universal symptoms of EGR are:
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| ** Skin eruptions
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| ** Intense pruritus
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| * Other symptoms related to the associated internal malignancy are:
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| ** Weight loss
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| ** Anorexia
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| ** Fatigue
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| ** Fever
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| **Many patients with EGR and malignancy had a history of tobacco smoking
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| **some patients with EGR and malignancy have a family history of neoplasm
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| ===Physical Examination===
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| * Patients with EGR can be ill-appearing and lethargic
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| * Thorough physical exam should be done to look for signs of malignancy as lymph node enlargements, mass, abdominal distension, shortness of breath, pleural effusion,or papilloedema.
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| * The rash consisting of wavy erythematous concentric bands that can be figurate, gyrate, or annular.
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| * The bands are arranged in parallel rings and lined by a fine trailing edge of scale, a pattern often described as “wood grained.
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| * The rash typically involves large areas of the body but tends to spare the face, hands, and feet and it can expand as fast as a cm a day.
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| * Bullae can also form from within the areas of erythema <ref name="pmidPMID: 22224159">{{cite journal| author=Gore M, Winters ME| title=Erythema gyratum repens: a rare paraneoplastic rash. | journal=West J Emerg Med | year= 2011 | volume= 12 | issue= 4 | pages= 556-8 | pmid=PMID: 22224159 | doi=10.5811/westjem.2010.11.2090 | pmc=3236141 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22224159 }} </ref>
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| ===Laboratory Findings===
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| * There are no diagnostic laboratory findings associated with EGR.
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| * Eosinophilia is observed in 60% of cases <ref name="pmidPMID: 22224159">{{cite journal| author=Gore M, Winters ME| title=Erythema gyratum repens: a rare paraneoplastic rash. | journal=West J Emerg Med | year= 2011 | volume= 12 | issue= 4 | pages= 556-8 | pmid=PMID: 22224159 | doi=10.5811/westjem.2010.11.2090 | pmc=3236141 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22224159 }} </ref>
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| * Evaluation to exclude systemic involvement:
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| ** CBC, CMP, urine analysis, LFT, guaiac stool test, serum protein electrophoresis
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| === Imaging Findings===
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| * There are no imaging findings associated with EGR.
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| * Imaging of the chest and abdomen could show malignancy findings.
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| ===Other Diagnostic Studies===
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| * Direct immunofluorescence in some cases shows patterns of IgG, C3, and C4 at the basement membrane <ref name="pmidPMID: 22224159">{{cite journal| author=Gore M, Winters ME| title=Erythema gyratum repens: a rare paraneoplastic rash. | journal=West J Emerg Med | year= 2011 | volume= 12 | issue= 4 | pages= 556-8 | pmid=PMID: 22224159 | doi=10.5811/westjem.2010.11.2090 | pmc=3236141 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22224159 }} </ref>
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| * The histopathologic features of EGR is non-specific.
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| * Biopsy specimens show the following:
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| ** Acanthosis, mild hyperkeratosis, focal parakeratosis, and spongiosis confined to the epidermis and superficial dermis.
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| ** Mononuclear, lymphocytic, and histiocytic perivascular infiltrate in the superficial plexus can also be seen <ref name="pmidPMID: 22224159">{{cite journal| author=Gore M, Winters ME| title=Erythema gyratum repens: a rare paraneoplastic rash. | journal=West J Emerg Med | year= 2011 | volume= 12 | issue= 4 | pages= 556-8 | pmid=PMID: 22224159 | doi=10.5811/westjem.2010.11.2090 | pmc=3236141 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22224159 }} </ref>
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| * Thorough paraneoplastic workup includes: <ref name="pmidPMID: 31111084">{{cite journal| author=Ridge A, Tummon O, Laing M| title=Response to "Transformation from pityriasis rubra pilaris to erythema gyratum repens-like eruption without associated malignancy: A report of 2 cases". | journal=JAAD Case Rep | year= 2019 | volume= 5 | issue= 5 | pages= 461-462 | pmid=PMID: 31111084 | doi=10.1016/j.jdcr.2019.03.012 | pmc=6510971 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31111084 }} </ref>
| |
| ** Computed tomography of thorax, abdomen, and pelvis
| |
| ** Positron emission tomography/computed tomography
| |
| ** Upper and lower gastrointestinal endoscopy
| |
| ** Tumor markers
| |
| ** Blood tests including lactate dehydrogenase and QuantiFERON to exclude tuberculosis.
| |
| | |
| ==Treatment==
| |
| '''Medical Therapy'''
| |
| * There is no treatment for EGR; the mainstay of therapy is supportive care and treating the underlying condition <ref name="pmidPMID: 22224159">{{cite journal| author=Gore M, Winters ME| title=Erythema gyratum repens: a rare paraneoplastic rash. | journal=West J Emerg Med | year= 2011 | volume= 12 | issue= 4 | pages= 556-8 | pmid=PMID: 22224159 | doi=10.5811/westjem.2010.11.2090 | pmc=3236141 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22224159 }} </ref>
| |
| * Various dermatologic and immunosuppressive therapies have been used to treat EGR.
| |
| * Systemic steroids are frequently ineffective.
| |
| * Topical steroids, vitamin A, and azathioprine have also failed to relieve skin manifestations.
| |
| * Improvement of EGR, and its associated intense pruritus depends on recognition and treatment of the underlying malignancy.
| |
| * Chemotherapy can be used to treat the internal malignancy.
| |
| | |
| ===Surgery===
| |
| * Surgical resection of the internal tumor could be recommended as part of the management of EGR.
| |
| '''Prevention'''
| |
| * There are no primary preventive measures available for [disease name].
| |
| | |
| | |
| ==References==
| |
| {{reflist|2}}
| |
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