Transmembrane Protein 205: Difference between revisions

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'''Transmembrane Protein 205''' (TMEM205) is a [[protein]] encoded on chromosome 19 by the TMEM205 [[gene]].
'''Transmembrane Protein 205''' (TMEM205) is a [[protein]] encoded on chromosome 19 by the TMEM205 [[gene]].
{{Infobox gene}}
{{Infobox gene}}


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== Homology ==
== Homology ==
TMEM205 has no known [[Paralogs]]  in the Human genome. Usinc UCSC genome browser BLAT<ref>{{cite journal|last=Kent|first=WJ|title=BLAT - the BLAST-like alignment tool|journal=Genome Res|date=April 2012|volume=12|issue=4|pages=656–664|url=http://genome.cshlp.org/content/12/4/656.abstract|accessdate=7 May 2013|doi=10.1101/gr.229202|pmid=11932250|pmc=187518}}</ref>  against the human protein sequence it was found that the closest relative to humans to contain a paralog of the TMEM205 gene in its genome is the [[Galago|Bushbaby]]. TMEM205 does however have a large range of [[Ortholog]] sequences.
TMEM205 has no known [[Paralogs]]  in the Human genome. Usinc UCSC genome browser BLAT<ref>{{cite journal | vauthors = Kent WJ | title = BLAT--the BLAST-like alignment tool | journal = Genome Research | volume = 12 | issue = 4 | pages = 656–64 | date = April 2002 | pmid = 11932250 | pmc = 187518 | doi = 10.1101/gr.229202 | url = http://genome.cshlp.org/content/12/4/656.abstract }}</ref>  against the human protein sequence it was found that the closest relative to humans to contain a paralog of the TMEM205 gene in its genome is the [[Galago|Bushbaby]]. TMEM205 does however have a large range of [[Ortholog]] sequences.
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== Expression ==
== Expression ==
TMEM205 has been shown to be expressed in greater amounts in tissues that have secretory function. These tissues include the thyroid, adrenal gland, pancrease, and mammary tissues.<ref name="pmid20589834">{{cite journal|last=Shen|first=DW|title=Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance.|journal=Journal of Cell Physiology|date=November 2010|volume=225|pmid=20589834|doi=10.1002/jcp.22287|pages=822–8|pmc=2971691|issue=3}}</ref> The protein has also been shown to have increased expression in tumor tissue that have become resistant to platinum based chemotherapy drugs.
TMEM205 has been shown to be expressed in greater amounts in tissues that have secretory function. These tissues include the thyroid, adrenal gland, pancrease, and mammary tissues.<ref name="pmid20589834">{{cite journal | vauthors = Shen DW, Ma J, Okabe M, Zhang G, Xia D, Gottesman MM | title = Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance | journal = Journal of Cellular Physiology | volume = 225 | issue = 3 | pages = 822–8 | date = November 2010 | pmid = 20589834 | pmc = 2971691 | doi = 10.1002/jcp.22287 }}</ref> The protein has also been shown to have increased expression in tumor tissue that have become resistant to platinum based chemotherapy drugs.


== Function ==
== Function ==
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==Interacting proteins==
==Interacting proteins==
TMEM205 has been shown to be co-located with RAB8 a known [[GTPase]] involved in vesicular traffic.<ref>{{cite journal|last=Shen|first=DW|author2=Gottesman |title=MM|journal=Pharm Res|date=March 2012|volume=29|series=3|pages=643–650|pmid=21969054|doi=10.1007/s11095-011-0562-y|issue=3|pmc=3288766}}</ref>
TMEM205 has been shown to be co-located with RAB8 a known [[GTPase]] involved in vesicular traffic.<ref>{{cite journal | vauthors = Shen DW, Gottesman MM | title = RAB8 enhances TMEM205-mediated cisplatin resistance | journal = Pharmaceutical Research | volume = 29 | issue = 3 | pages = 643–50 | date = March 2012 | pmid = 21969054 | pmc = 3288766 | doi = 10.1007/s11095-011-0562-y }}</ref>


==Clinical significance==
==Clinical significance==

Latest revision as of 09:30, 21 January 2018

Transmembrane Protein 205 (TMEM205) is a protein encoded on chromosome 19 by the TMEM205 gene.

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Gene

TMEM205 is located on the minus strand of chromosome 19 from base pair 11,453,452 to 11,456,981. In close proximity to TMEM205, CCDC159 is located slightly upstream and RAB3D slightly down stream of the genomic sequence.

Homology

TMEM205 has no known Paralogs in the Human genome. Usinc UCSC genome browser BLAT[1] against the human protein sequence it was found that the closest relative to humans to contain a paralog of the TMEM205 gene in its genome is the Bushbaby. TMEM205 does however have a large range of Ortholog sequences.

Genus Species Organism common name Divergence from humans (MYA) [2] NCBI Protein Accession Sequence similarity [3] Protein length
Homo sapiens[4] Humans 0 AAH91472.1 100% 189
Pan troglodytes[5] Common Chimp 6.4 XP_003316117.1 100% 189
Pongo abelii [6] Orangutan 15.8 NP 001124814.1 99% 189
Gorilla gorilla [7] Gorilla 8.8 XP_004060075.1 99% 189
Callithrix jacchus [8] Common Marmoset 43.9 XP_002761800.1 96% 189
Mus musculus [9] Mouse 94.1 BAA92792764.1 88% 189
Sarcophilus harrisii [10] Tasmanian Devil 162.6 XP_003760487.1 77% 193
Crotalus adamanteus [11] Rattle Snake 296 AFJ51753.1 85% 188
Xenopus [12] Xenopus 371 NP_001037942.1 68% 189

Protein

The human homologue of TMEM205 is 189 amino acids long and has a molecular weight of 21.2 kDa. It contains 4 hydrophobic helical domains that are predicted to be transmembrane domains.

Expression

TMEM205 has been shown to be expressed in greater amounts in tissues that have secretory function. These tissues include the thyroid, adrenal gland, pancrease, and mammary tissues.[13] The protein has also been shown to have increased expression in tumor tissue that have become resistant to platinum based chemotherapy drugs.

Function

TMEM205 is thought to be a multi-pass transmembrane protein. It has been shown to be located at the plasma membrane in humans tissues and translocates to the nuclear envelope when cells become resistant to Cisplatin.[13] It contains four domains predicted to be trans membrane domains by TMHMM analysis.

Interacting proteins

TMEM205 has been shown to be co-located with RAB8 a known GTPase involved in vesicular traffic.[14]

Clinical significance

TMEM205 has been shown to be involved in Cisplatin resistance. Cisplatin is a Chemotheraputic drug that is commonly used to treat solid malignancies such as carcinomas, sarcomas, and lymphomas. In addition to being involved in Cisplatin resistance there is growing evidence that the protein is also involved in the diseases thyroiditis and prostatitis

Notes

  1. ↑ Kent WJ (April 2002). "BLAT--the BLAST-like alignment tool". Genome Research. 12 (4): 656–64. doi:10.1101/gr.229202. PMC 187518. PMID 11932250.
  2. ↑ "Time Tree".
  3. ↑ "NCBI BLAST".
  4. ↑ "NCBI Protein: AAH91472.1".
  5. ↑ "NCBI Protein: XP_003316117.1".
  6. ↑ "NCBI Protein: NP_001124814.1".
  7. ↑ "NCBI Protein: XP_004060075.1".
  8. ↑ "NCBI Protein: XP_002761800.1".
  9. ↑ "NCBI Protein: BAA92792764.1".
  10. ↑ "NCBI Nucleotide: XP_003760487.1".
  11. ↑ "NCBI Nucleotide: AFJ51753.1".
  12. ↑ "NCBI Nucleotide: NP_001037942.1".
  13. ↑ 13.0 13.1 Shen DW, Ma J, Okabe M, Zhang G, Xia D, Gottesman MM (November 2010). "Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance". Journal of Cellular Physiology. 225 (3): 822–8. doi:10.1002/jcp.22287. PMC 2971691. PMID 20589834.
  14. ↑ Shen DW, Gottesman MM (March 2012). "RAB8 enhances TMEM205-mediated cisplatin resistance". Pharmaceutical Research. 29 (3): 643–50. doi:10.1007/s11095-011-0562-y. PMC 3288766. PMID 21969054.
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