BAZ1A: Difference between revisions
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==Function== | ==Function== | ||
BAZ1A along with [[SMARCA5]], [[POLE3]], and [[CHRAC1]] comprise the WCRF/CHRAC ATP-dependent [[chromatin Structure Remodeling (RSC) Complex|chromatin-remodeling complex]].<ref name="pmid10655480">{{cite journal |vauthors=Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R | title = A family of chromatin remodeling factors related to Williams syndrome transcription factor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 3 | pages = 1038–43 |date=February 2000 | pmid = 10655480 | pmc = 15513 | url = http://www.pnas.org/cgi/pmidlookup?view=long&pmid=10655480| doi = 10.1073/pnas.97.3.1038 }}</ref><ref name="pmid10880450">{{cite journal |vauthors=Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD | title = HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins | journal = EMBO J. | volume = 19 | issue = 13 | pages = 3377–87 |date=July 2000 | pmid = 10880450 | pmc = 313940 | doi = 10.1093/emboj/19.13.3377 | url = }}</ref> | BAZ1A along with [[SMARCA5]], [[POLE3]], and [[CHRAC1]] comprise the WCRF/CHRAC ATP-dependent [[chromatin Structure Remodeling (RSC) Complex|chromatin-remodeling complex]].<ref name="pmid10655480">{{cite journal |vauthors=Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R | title = A family of chromatin remodeling factors related to Williams syndrome transcription factor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 3 | pages = 1038–43 |date=February 2000 | pmid = 10655480 | pmc = 15513 | url = http://www.pnas.org/cgi/pmidlookup?view=long&pmid=10655480| doi = 10.1073/pnas.97.3.1038 | bibcode = 2000PNAS...97.1038B }}</ref><ref name="pmid10880450">{{cite journal |vauthors=Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD | title = HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins | journal = EMBO J. | volume = 19 | issue = 13 | pages = 3377–87 |date=July 2000 | pmid = 10880450 | pmc = 313940 | doi = 10.1093/emboj/19.13.3377 | url = }}</ref> | ||
The purified CHRAC complex can mobilize [[nucleosome]]s into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent.<ref name="pmid10880450"/> Furthermore, the BAZ1A-SMARCA5 complex enables [[DNA replication]] through highly condensed regions of [[chromatin]].<ref name="pmid12434153">{{cite journal |vauthors=Collins N, Poot RA, Kukimoto I, García-Jiménez C, Dellaire G, Varga-Weisz PD | title = An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin | journal = Nat. Genet. | volume = 32 | issue = 4 | pages = 627–32 |date=December 2002 | pmid = 12434153 | doi = 10.1038/ng1046 | url = }}</ref> | The purified CHRAC complex can mobilize [[nucleosome]]s into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent.<ref name="pmid10880450"/> Furthermore, the BAZ1A-SMARCA5 complex enables [[DNA replication]] through highly condensed regions of [[chromatin]].<ref name="pmid12434153">{{cite journal |vauthors=Collins N, Poot RA, Kukimoto I, García-Jiménez C, Dellaire G, Varga-Weisz PD | title = An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin | journal = Nat. Genet. | volume = 32 | issue = 4 | pages = 627–32 |date=December 2002 | pmid = 12434153 | doi = 10.1038/ng1046 | url = }}</ref> | ||
==Interactions== | ==Interactions== | ||
BAZ1A has been shown to [[Protein-protein interaction|interact]] with [[SMARCA5]]<ref name=pmid10655480 /><ref name=pmid10880450 /><ref name=pmid11980720>{{cite journal |last=Bozhenok |first=Ludmila |authorlink= |author2=Wade Paul A |author3=Varga-Weisz Patrick |date=May 2002 |title=WSTF–ISWI chromatin remodeling complex targets heterochromatic replication foci |journal=EMBO J. |volume=21 |issue=9 |pages=2231–41 |publisher= |location = England| issn = 0261-4189| pmid = 11980720 |doi = 10.1093/emboj/21.9.2231 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=125993 }}</ref><ref name=pmid12374985>{{cite journal |last=Yasui |first=Dag |authorlink= |author2=Miyano Masaru |author3=Cai Shutao |author4=Varga-Weisz Patrick |author5=Kohwi-Shigematsu Terumi |date=Oct 2002 |title=SATB1 targets chromatin remodelling to regulate genes over long distances |journal=[[Nature (journal)|Nature]] |volume=419 |issue=6907 |pages=641–5 |publisher= |location = England| issn = 0028-0836| pmid = 12374985 |doi = 10.1038/nature01084 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12198550>{{cite journal |last=Hakimi |first=Mohamed-Ali |authorlink= |author2=Bochar Daniel A |author3=Schmiesing John A |author4=Dong Yuanshu |author5=Barak Orr G |author6=Speicher David W |author7=Yokomori Kyoko |author8=Shiekhattar Ramin |date=Aug 2002 |title=A chromatin remodelling complex that loads cohesin onto human chromosomes |journal=[[Nature (journal)|Nature]] |volume=418 |issue=6901 |pages=994–8 |publisher= |location = England| issn = 0028-0836| pmid = 12198550 |doi = 10.1038/nature01024 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[SATB1]].<ref name=pmid12374985/> | BAZ1A has been shown to [[Protein-protein interaction|interact]] with [[SMARCA5]]<ref name=pmid10655480 /><ref name=pmid10880450 /><ref name=pmid11980720>{{cite journal |last=Bozhenok |first=Ludmila |authorlink= |author2=Wade Paul A |author3=Varga-Weisz Patrick |date=May 2002 |title=WSTF–ISWI chromatin remodeling complex targets heterochromatic replication foci |journal=EMBO J. |volume=21 |issue=9 |pages=2231–41 |publisher= |location = England| issn = 0261-4189| pmid = 11980720 |doi = 10.1093/emboj/21.9.2231 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=125993 }}</ref><ref name=pmid12374985>{{cite journal |last=Yasui |first=Dag |authorlink= |author2=Miyano Masaru |author3=Cai Shutao |author4=Varga-Weisz Patrick |author5=Kohwi-Shigematsu Terumi |date=Oct 2002 |title=SATB1 targets chromatin remodelling to regulate genes over long distances |journal=[[Nature (journal)|Nature]] |volume=419 |issue=6907 |pages=641–5 |publisher= |location = England| issn = 0028-0836| pmid = 12374985 |doi = 10.1038/nature01084 | bibcode =2002Natur.419..641Y | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12198550>{{cite journal |last=Hakimi |first=Mohamed-Ali |authorlink= |author2=Bochar Daniel A |author3=Schmiesing John A |author4=Dong Yuanshu |author5=Barak Orr G |author6=Speicher David W |author7=Yokomori Kyoko |author8=Shiekhattar Ramin |date=Aug 2002 |title=A chromatin remodelling complex that loads cohesin onto human chromosomes |journal=[[Nature (journal)|Nature]] |volume=418 |issue=6901 |pages=994–8 |publisher= |location = England| issn = 0028-0836| pmid = 12198550 |doi = 10.1038/nature01024 | bibcode =2002Natur.418..994H | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[SATB1]].<ref name=pmid12374985/> | ||
==References== | ==References== | ||
Latest revision as of 06:17, 10 January 2019
Bromodomain adjacent to zinc finger domain protein 1A is a protein that in humans is encoded by the BAZ1A gene.[1][2]
Structure
The protein encoded by this gene belongs to a family of proteins which includes BAZ1B, BAZ2A, and BAZ2B. All family members contain the following domains and structural motifs:[1]
- N-terminus – PHD finger (C4HC3 zinc finger)
- WAKZ motif
- LH (leucine-rich helical domain) motif
- C-terminus – bromodomain
Function
BAZ1A along with SMARCA5, POLE3, and CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex.[3][4]
The purified CHRAC complex can mobilize nucleosomes into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent.[4] Furthermore, the BAZ1A-SMARCA5 complex enables DNA replication through highly condensed regions of chromatin.[5]
Interactions
BAZ1A has been shown to interact with SMARCA5[3][4][6][7][8] and SATB1.[7]
References
- ↑ 1.0 1.1 Jones MH, Hamana N, Nezu J, Shimane M (Apr 2000). "A novel family of bromodomain genes". Genomics. 63 (1): 40–5. doi:10.1006/geno.1999.6071. PMID 10662543.
- ↑ "Entrez Gene: BAZ1A bromodomain adjacent to zinc finger domain, 1A".
- ↑ 3.0 3.1 Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R (February 2000). "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1038–43. Bibcode:2000PNAS...97.1038B. doi:10.1073/pnas.97.3.1038. PMC 15513. PMID 10655480.
- ↑ 4.0 4.1 4.2 Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (July 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
- ↑ Collins N, Poot RA, Kukimoto I, García-Jiménez C, Dellaire G, Varga-Weisz PD (December 2002). "An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin". Nat. Genet. 32 (4): 627–32. doi:10.1038/ng1046. PMID 12434153.
- ↑ Bozhenok, Ludmila; Wade Paul A; Varga-Weisz Patrick (May 2002). "WSTF–ISWI chromatin remodeling complex targets heterochromatic replication foci". EMBO J. England. 21 (9): 2231–41. doi:10.1093/emboj/21.9.2231. ISSN 0261-4189. PMC 125993. PMID 11980720.
- ↑ 7.0 7.1 Yasui, Dag; Miyano Masaru; Cai Shutao; Varga-Weisz Patrick; Kohwi-Shigematsu Terumi (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature. England. 419 (6907): 641–5. Bibcode:2002Natur.419..641Y. doi:10.1038/nature01084. ISSN 0028-0836. PMID 12374985.
- ↑ Hakimi, Mohamed-Ali; Bochar Daniel A; Schmiesing John A; Dong Yuanshu; Barak Orr G; Speicher David W; Yokomori Kyoko; Shiekhattar Ramin (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature. England. 418 (6901): 994–8. Bibcode:2002Natur.418..994H. doi:10.1038/nature01024. ISSN 0028-0836. PMID 12198550.
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