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According to Gonzalez-Crussi System, Sacrococcygeal teratoma is graded on a scale from 0-3, based on the histology:<ref name = "cs">Myers LB, Bulich LA. Anesthesia for Fetal Intervention and Surgery. PMPH-USA; 2005.</ref><ref name = "ad">{{cite journal |vauthors=Harms D, Zahn S, Göbel U, Schneider DT |title=Pathology and molecular biology of teratomas in childhood and adolescence |journal=Klin Padiatr |volume=218 |issue=6 |pages=296–302 |year=2006 |pmid=17080330 |doi=10.1055/s-2006-942271 |url=}}</ref>
===Discovery===
 
*The oldest evidence of cancer is discovered in the Egyptian literature and dates back to about 3000 BC. The textbook is called the 'Edwin Smith Papyrus' and describes 8 cases of tumors of the breast that were removed by [[cauterization]] with a tool called the fire drill. The writing says about the disease, “There is no treatment.<ref>{{cite web
{| style="border: 0px; font-size: 90%; margin: 3px; width: 800px"
  | title = The History of Cancer
|valign=top|
  | work = [[American Cancer Society]]
|+
  | date = 2002-03-25
! style="background: #4479BA; width: 100px;" | {{fontcolor|#FFF|Grade}}
  | url = http://www.cancer.org/docroot/CRI/content/CRI_2_6x_the_history_of_cancer_72.asp?sitearea=CRI
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Microscopic Features}}
  | accessdate = 2006-10-09 }}</ref>  
|-
===Landmark Events in the Development of Treatment Strategies===
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
*In 1761, Giovanni Morgagni of Padua became the first to perform an autopsy to relate the illness to the pathology.
'''Grade 0'''
* The Scottish surgeon John Hunter (1728-1793) suggested that cancer could be removed if tumor had not invaded nearby tissue and was 'moveable'.
| style="padding: 5px 5px; background: #F5F5F5;" |
*In 1700s, John Hunter, the Scottish surgeon suggested that tumors grow from lymph constantly thrown out by the blood.
*Tumor contains only mature tissue
*In 19th century, Rudolf Virchow became the first to correlate the illness to microscopic pathology.
|-
*Zacutus Lusitani (1575-1642) and Nicholas Tulp (1593-1674), 2 doctors in Holland, publicized their work in 1649 and 1652 respectively that concluded that breast cancer was contagious based on their observation of the tumor in the members of the same household.
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
*In the 1990s, BRCA1 and BRCA2 genes were associated with development of breast cancer for first time.
'''Grade I'''
*In 1713, Bernardino Ramazzini, an Italian doctor, reported the relatively high incidence of breast cancer in nuns. This observation made it a clear association between breast cancer and role of hormones.
| style="padding: 5px 5px; background: #F5F5F5;" |
*In late 1960s, modern mammography methods were developed.
*Tumor contains rare foci of immature tissues
*In 1976, mammography became officially recommended by the American cancer society.
*Less than 10% tissue is Immature
*In the last decade of the 19th century, William Stewart Halsted, professor of surgery at Johns Hopkins University, came up with the radical mastectomy procedure.
|-
*In 1719, Lorenz Heister, a German surgeon wrote about his ideas for mastectomy and lumpectomy in his book, Chirurgie.
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
*In 1896, Thomas Beatson, a graduate from the University of Edinburgh, described the relationship between oophorectomy and breast cancer. This study laid down the foundation of the hormonal therapy of the breast cancer.
'''Grade II'''
*In the 1970s, modern clinical trials demonstrated that less extensive surgery is equally effective for most women with breast cancer.
| style="padding: 5px 5px; background: #F5F5F5;" |
*During the final decades of the 20th century, technices were developed to minimizing the amount of normal tissue removed along with the tumor.
* Tumor contains moderate quantities of immature tissues.
*In late 1990s, first therapeutic monoclonal antibodies, trastuzumab (Herceptin) was approved for breast cancer.
* Upto 10-50% tissue in immature
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
'''Grade III'''
| style="padding: 5px 5px; background: #F5F5F5;" |
*Tumor contains large quantities of immature tissue with or without malignant yolk sac elements.  
*More than 50% tissue is immature
|}

Latest revision as of 21:50, 23 January 2016

Discovery

  • The oldest evidence of cancer is discovered in the Egyptian literature and dates back to about 3000 BC. The textbook is called the 'Edwin Smith Papyrus' and describes 8 cases of tumors of the breast that were removed by cauterization with a tool called the fire drill. The writing says about the disease, “There is no treatment.”[1]

Landmark Events in the Development of Treatment Strategies

  • In 1761, Giovanni Morgagni of Padua became the first to perform an autopsy to relate the illness to the pathology.
  • The Scottish surgeon John Hunter (1728-1793) suggested that cancer could be removed if tumor had not invaded nearby tissue and was 'moveable'.
  • In 1700s, John Hunter, the Scottish surgeon suggested that tumors grow from lymph constantly thrown out by the blood.
  • In 19th century, Rudolf Virchow became the first to correlate the illness to microscopic pathology.
  • Zacutus Lusitani (1575-1642) and Nicholas Tulp (1593-1674), 2 doctors in Holland, publicized their work in 1649 and 1652 respectively that concluded that breast cancer was contagious based on their observation of the tumor in the members of the same household.
  • In the 1990s, BRCA1 and BRCA2 genes were associated with development of breast cancer for first time.
  • In 1713, Bernardino Ramazzini, an Italian doctor, reported the relatively high incidence of breast cancer in nuns. This observation made it a clear association between breast cancer and role of hormones.
  • In late 1960s, modern mammography methods were developed.
  • In 1976, mammography became officially recommended by the American cancer society.
  • In the last decade of the 19th century, William Stewart Halsted, professor of surgery at Johns Hopkins University, came up with the radical mastectomy procedure.
  • In 1719, Lorenz Heister, a German surgeon wrote about his ideas for mastectomy and lumpectomy in his book, Chirurgie.
  • In 1896, Thomas Beatson, a graduate from the University of Edinburgh, described the relationship between oophorectomy and breast cancer. This study laid down the foundation of the hormonal therapy of the breast cancer.
  • In the 1970s, modern clinical trials demonstrated that less extensive surgery is equally effective for most women with breast cancer.
  • During the final decades of the 20th century, technices were developed to minimizing the amount of normal tissue removed along with the tumor.
  • In late 1990s, first therapeutic monoclonal antibodies, trastuzumab (Herceptin) was approved for breast cancer.
  1. "The History of Cancer". American Cancer Society. 2002-03-25. Retrieved 2006-10-09.